A5058573957- Developmental Biology and Gene Regulation
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Silk-based biomaterials and applications
- Muscle metabolism and nutrition
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Peptides and Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Ear and Nasal Anomalies
- Neurogenesis and neuroplasticity mechanisms
- Lung Cancer Research Studies
- Congenital Diaphragmatic Hernia Studies
- Head and Neck Surgical Oncology
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Hedgehog Signaling Pathway Studies
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Zebrafish Biomedical Research Applications
- Planarian Biology and Electrostimulation
- Wnt/β-catenin signaling in development and cancer
- Gut microbiota and health
- Diet and metabolism studies
University of Ioannina
2018-2022
Institute of Structural and Molecular Biology
2015-2022
University College London
2014-2022
FORTH Institute of Molecular Biology and Biotechnology
2021
Institute of Molecular Biology and Biotechnology
2019
King's College London
2018-2019
Queen Mary University of London
2017
We report the production and metabolic phenotype of a mouse line in which Fmo5 gene is disrupted. In comparison with wild-type (WT) mice, Fmo5−/− mice exhibit lean phenotype, age-related, becoming apparent after 20 weeks age. Despite greater food intake, weigh less, store less fat white adipose tissue (WAT), have lower plasma glucose cholesterol concentrations enhanced whole-body energy expenditure, due mostly to increased resting no increase physical activity. An respiratory exchange ratio...
Neural crest migration is critical to its physiological function. Mechanisms controlling mammalian neural are comparatively unknown, due difficulties accessing this cell population in vivo. Here we report requirements of glycogen synthase kinase 3 (GSK3) regulating the Xenopus and mouse models. We demonstrate that GSK3 tyrosine phosphorylated (pY) cells loss leads increased pFAK misregulation Rac1 lamellipodin, key regulators migration. Genetic reduction results failure find pY-GSK3...
Abstract Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of amputation level. This suggests that cells in stump have awareness their spatial location, a property termed positional identity. Little known about how identity encoded, salamanders or other biological systems. Through single-cell RNAseq analysis, we identified Tig1/Rarres1 as potential determinant proximal Tig1 encodes conserved cell surface molecule,...
We have previously identified flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic aging. The aim the present study was to investigate role FMO5 in glucose homeostasis and impact diet gut flora on phenotype mice which Fmo5 gene has been disrupted (Fmo5-/- mice). In comparison with wild-type (WT) counterparts, Fmo5-/- are resistant age-related changes maintain higher tolerance insulin sensitivity characteristic young animals. When fed high-fat diet, they protected against...
Over the past several decades there has been an increased availability of genetically modified mouse models used to mimic human pathologies. However, ability study cell movements and differentiation in vivo is still very difficult. Neurocristopathies, or disorders neural crest lineage, are particularly challenging due a lack accessibility key embryonic stages difficulties separating out mesenchyme from adjacent mesodermal mesenchyme. Here, we set establish well-defined, routine protocol for...
Neuroblastoma is one of the most common and deadly childhood cancers. arises from transformed cells neural crest lineage. Outcomes disease vary greatly, ranging spontaneous regression to aggressive metastases. While this variability may reflect inherent migratory capabilities multipotency cells, there have been few direct comparisons between neuroblastoma embryonic in part because limited vivo accessibility mammalian Our recent studies demonstrate a novel link anaplastic lymphoma kinase...
ABSTRACT Although rare, childhood (paediatric) cancers are a major cause of death in young children. Unlike many adult cancers, paediatric such as neuroblastoma (NB), developmental diseases that rarely show genetic predispositions. NB is the most common extracranial solid tumour children, accounting for ∼15% cancer deaths. This heterogeneous arises from undifferentiated neural crest-derived progenitor cells. As crest cells multipotent and migratory, they often considered embryonic paradigm...
Abstract Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of amputation level. This suggests that cells in stump have awareness their spatial location, a property termed ‘positional identity’. Little known about how positional identity encoded, salamanders or other biological systems. Through single-cell RNAseq analysis, we identified Tig1/Rarres1 as potential determinant proximal identity. Tig1 encodes conserved cell...
Abstract Migration of the neural crest lineage is critical to its physiological function. Mechanisms controlling migration are comparatively unknown, due difficulties accessing this cell population in vivo . Here, we uncover novel requirements glycogen synthase kinase 3 (GSK3) regulating crest. We demonstrate that GSK3 tyrosine phosphorylated (pY) cells and activation depends on anaplastic lymphoma (ALK), a protein associated with neuroblastoma. Consistent this, neuroblastoma pathologically...
Over the past several decades there has been an increased availability of genetically modified mouse models used to mimic human pathologies. However, ability study cell movements and differentiation in vivo is still very difficult. Neurocristopathies, or disorders neural crest lineage, are particularly challenging due a lack accessibility key embryonic stages difficulties separating out mesenchyme from adjacent mesodermal mesenchyme. Here, we set establish well-defined, routine protocol for...