A5057235883- Machine Learning in Bioinformatics
- Protein Structure and Dynamics
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Enzyme Structure and Function
- 2D Materials and Applications
- Amino Acid Enzymes and Metabolism
- Magnetic properties of thin films
- Microtubule and mitosis dynamics
- Graphene research and applications
- Glycosylation and Glycoproteins Research
- Advanced Sensor and Energy Harvesting Materials
- Nanowire Synthesis and Applications
- Innovative Energy Harvesting Technologies
- Heusler alloys: electronic and magnetic properties
- Magnetic Properties and Applications
- Electrowetting and Microfluidic Technologies
- Microbial Metabolic Engineering and Bioproduction
- MXene and MAX Phase Materials
- ZnO doping and properties
- Bacteriophages and microbial interactions
- vaccines and immunoinformatics approaches
- Photonic and Optical Devices
- Tuberculosis Research and Epidemiology
Indian Institute of Technology Delhi
2022-2024
Indian Institute of Technology Madras
2023
University of Missouri
2023
University of Gothenburg
2023
Indian Institute of Science Bangalore
2011-2018
Interaction Institute for Social Change
2015
Spin-to-charge conversion is an essential requirement for the implementation of spintronic devices. Recently, monolayers (MLs) semiconducting transition-metal dichalcogenides (TMDs) have attracted considerable interest spin-to-charge due to their high spin-orbit coupling and lack inversion symmetry in crystal structure. However, reports direct measurement at TMD-based interfaces are very much limited. Here, we report on room-temperature observation a large arising from interface Ni80Fe20...
In the post-genomic era where sequences are being determined at a rapid rate, we highly reliant on computational methods for their tentative biochemical characterization. The Pfam database currently contains 3,786 families corresponding to "Domains of Unknown Function" (DUF) or "Uncharacterized Protein Family" (UPF), which 3,087 have no reported three-dimensional structure, constituting almost one-fourth known protein in search both structure and function.We applied 'computational structural...
We performed spin-torque ferromagnetic resonance studies on the Al/NiFe/AlOx heterostructure. observed a large non-trivial field-like torque, τFLz, due to out-of-plane spin polarization, despite lack of heavy metal in our multilayer. The torque conductivity is found be significant with value equal σFLz=(21±2)ℏ2e×103 Ω−1m−1. From detailed Al thickness dependence, we show that τFLz arises from interface between and NiFe. demonstrate spin-swapping mechanism at Al/NiFe rather than orbital Hall...
As a topological Dirac semimetal with controllable spin–orbit coupling and conductivity, PtSe2, transition-metal dichalcogenide, is promising material for several applications, from optoelectrics to sensors. However, its potential spintronics applications has yet be explored. In this work, we demonstrate that the PtSe2/Ni80Fe20 heterostructure can generate large damping-like current-induced torques (SOT), despite absence of spin-splitting in bulk PtSe2. The efficiency charge-to-spin...
Here, we report on the comprehensive growth, characterization, and optoelectronic application of large-area, two-dimensional germanium selenide (GeSe) layers prepared using pulsed laser deposition (PLD) technique. Back-gated phototransistors based few-layered 2D GeSe have been fabricated a SiO2/Si substrate for ultrafast, low noise, broadband light detection, showing spectral functionalities over broad wavelength range 0.4-1.5 μm. The detection capabilities device attributed to...
NrichD (http://proline.biochem.iisc.ernet.in/NRICHD/) is a database of computationally designed protein-like sequences, augmented into natural sequence databases that can perform hops in protein space to assist the detection remote relationships. Establishing relationships absence structural evidence or ‘intermediately related sequences’ challenging task. Recently, we have demonstrated computational design artificial intermediary sequences/linkers an effective approach fill naturally...
Over the past two decades, many ingenious efforts have been made in protein remote homology detection. Because homologous proteins often diversify extensively sequence, it is challenging to demonstrate such relatedness through entirely sequence-driven searches. Here, we describe a computational method for generation of 'protein-like' sequences that serves bridge gaps sequence space. Sequence profile information, as embodied position-specific scoring matrix multiply aligned bona fide family...
ABSTRACT Functional annotation is seldom straightforward with complexities arising due to functional divergence in protein families or convergence between non‐homologous families, leading mis‐annotations. An enzyme may contain multiple domains and not all be involved a given function, adding the complexity function annotation. To address this, we use binding site information from bound cognate ligands catalytic residues, since it can help resolving fold‐function relationships at finer level...
Knowledge of the protein structure is a pre-requisite for improved understanding molecular function. The gap in sequence-structure space has increased post-genomic era. Grouping related sequences into families can aid narrowing gap. In Pfam database, description provided part or full-length proteins 7726 families. For remaining 52% families, information on 3-D not yet available. We use computationally designed that are intermediately to two domain which already known share same fold. These...
This paper reports a water droplet-based electrostatic energy harvester which is based on rolling of droplet well-defined hydrophilic channel (SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ) having precharged hydrophobic film CYTOP as side walls. material has high charge trapping potential because breakdown voltage in the range 132 V/μm, The developed device works variable capacitor model, and converts mechanical motion into...
In the post-genomic era, biological databases are growing at a tremendous rate. Despite rapid accumulation of information, functions and other properties many putative gene products various organisms remain either unknown or obscure. This paper examines how strategic integration large combinations information helps address some fundamental questions on protein structure, function interactions. New developments in recognition by remote homology detection use sequence aid newly discovered...
First clue to function of a protein known sequence is often obtained on the basis its evolutionary relationship with another functional properties. Therefore our ability r...
<p>Supplementary Figures S1-S4 and Supplementary Tables S1-S2.</p>
<p>Supplementary Figures S1-S4 and Supplementary Tables S1-S2.</p>
As a topological Dirac semimetal with controllable spin-orbit coupling and conductivity, PtSe$_2$, transition-metal dichalcogenide, is promising material for several applications from optoelectric to sensors. However, its potential spintronics yet be explored. In this work, we demonstrate that PtSe$_{2}$/Ni$_{80}$Fe$_{20}$ heterostructure can generate large damping-like current-induced torques (SOT), despite the absence of spin-splitting in bulk PtSe$_{2}$. The efficiency charge-to-spin...
<div>Abstract<p>BLM helicase, the protein mutated in Bloom syndrome, is involved signal transduction cascades after DNA damage. BLM phosphorylated on multiple residues by different kinases either stress induction or during mitosis. Here, we have provided evidence that both Chk1 and Chk2 NH<sub>2</sub>-terminal 660 amino acids of BLM. An internal region within DExH motif negatively regulated Chk1/Chk2-dependent phosphorylation event. Using <i>in silico</i>...
<div>Abstract<p>BLM helicase, the protein mutated in Bloom syndrome, is involved signal transduction cascades after DNA damage. BLM phosphorylated on multiple residues by different kinases either stress induction or during mitosis. Here, we have provided evidence that both Chk1 and Chk2 NH<sub>2</sub>-terminal 660 amino acids of BLM. An internal region within DExH motif negatively regulated Chk1/Chk2-dependent phosphorylation event. Using <i>in silico</i>...