A5051043606- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Tuberous Sclerosis Complex Research
- Death Anxiety and Social Exclusion
- Cell Image Analysis Techniques
- Psychosomatic Disorders and Their Treatments
- Suicide and Self-Harm Studies
- Fractal and DNA sequence analysis
- Retinal Imaging and Analysis
- Gene expression and cancer classification
- Neurosurgical Procedures and Complications
- Neuroscience and Neuropharmacology Research
- Genetics, Bioinformatics, and Biomedical Research
- Neural dynamics and brain function
- Psychology of Moral and Emotional Judgment
- Stress Responses and Cortisol
- Biomedical Text Mining and Ontologies
- Tryptophan and brain disorders
- Neural and Behavioral Psychology Studies
- Long-Term Effects of COVID-19
- Neurofibromatosis and Schwannoma Cases
University of Padua
2021-2024
Radboud University Medical Center
2023-2024
Radboud University Nijmegen
2023-2024
University Medical Center
2023
The highly polygenic and pleiotropic nature of behavioural traits, psychiatric disorders structural functional brain phenotypes complicate mechanistic interpretation related genome-wide association study (GWAS) signals, thereby obscuring underlying causal biological processes. We propose genomic principal independent component analysis (PCA, ICA) to decompose a large set univariate GWAS statistics multimodal traits into more interpretable latent components. Here we introduce evaluate this...
Cognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-related differences. Genetic variants the DTBPN1 gene associated reduced dysbindin-1 protein (Dys) expression negatively impact cognitive functions in schizophrenia through a functional epistatic interaction Catechol-O-methyltransferase (COMT). Dys is involved trafficking dopaminergic receptors, crucial for prefrontal cortex (PFC) signaling regulation. Moreover, dopamine modulated by estrogens via...
Understanding the genetic basis of individual differences in human brain structure and function remains a major challenge. Traditional genome-wide association studies (GWAS) have identified numerous variants associated with phenotypes, but their interpretation is complicated by polygenicity pleiotropy. To address this, we applied genomICA, data-driven multivariate method, to GWAS summary statistics thousands MRI-derived phenotypes from 33,224 UK Biobank participants. genomICA decomposes...
Abstract Cocaine use is a worldwide health problem with psychiatric, somatic and socioeconomic complications, being the second most widely used illicit drug in world. Despite several structural neuroimaging studies, alterations cortical morphology associated cocaine addiction are still poorly understood. In this study, we compared complexity of folding (CCF), measure that aims to summarize convoluted structure cortex between patients ( n = 52) controls 36), correlated it characteristics...
The complex structure of the brain supports high-order cognition, which is crucial for mastering chess. Surface-based measures, including fractional dimension (FD) and gyrification index (GI), may be more sensitive in detecting cortical changes relative to volumetric indexes. For this reason, structural magnetic resonance imaging data from 29 chess experts novice participants were analyzed using CAT12 toolbox. FD GI each region compared between groups. A multivariate model was used identify...
Abstract Facial emotion recognition (FER), including sadness, is altered in bipolar disorder (BD). However, the relationship between this impairment and brain structure BD relatively unexplored. Furthermore, its association with clinical variables subtypes of remains to be clarified. Twenty euthymic patients type I (BD-I), 28 II (BD-II), 45 healthy controls completed a FER test 3D-T1-weighted magnetic resonance imaging. Gray matter volume (GMV) cortico-limbic regions implicated emotional...
Abstract Widespread regional gray matter volume (GMV) alterations have been reported in bipolar disorder (BD). Structural networks, which are thought to better reflect the complex multivariate organization of brain, and their clinical psychological function not investigated yet BD. 24 patients with BD type-I (BD-I), 30 type-II (BD-II), 45 controls underwent MRI scan. Voxel-based morphometry source-based (SBM) were performed extract structural covariation patterns GMV. SBM components...
Antisocial behavior involves actions that disregard the basic rights of others and may represent a threat to social system. The neural processes associated with being subject antisocial behavior, including victimization, are still unknown. In this study, we used interaction task during functional magnetic resonance imaging investigate bases victimization. Brain activation connectivity (FC) were estimated correlated Big 5 Questionnaire, Temperament Evaluation in Memphis, Pisa San Diego...
Abstract Introduction The highly polygenic and pleiotropic nature of behavioural traits, psychiatric disorders, structural functional brain phenotypes complicate mechanistic interpretation related genome-wide association study (GWAS) signals, such that the underlying causal biological processes remain obscure. We propose novel method genomic principal independent component analysis (PCA, ICA) to decompose a large set univariate GWAS statistics multimodal traits into more interpretable latent...
An antisocial behavior entails acts without taking into account the basic rights of others and may represent a threaten to social system. The neural processes associated with experiencing (social victimization) are still unknown. In this study, we used interaction task during functional magnetic resonance imaging( investigate bases victimization. Brain activation connectivity (FC) were estimated correlated Big-5-Questionnaire, TEMPS-M Questionnaire Daily-Frustration scores. During...