A5101355389- Genetic and Kidney Cyst Diseases
- Pediatric Urology and Nephrology Studies
- MRI in cancer diagnosis
- Renal and related cancers
- Fetal and Pediatric Neurological Disorders
- Renal cell carcinoma treatment
- Bone and Joint Diseases
- Cardiovascular Function and Risk Factors
- Dialysis and Renal Disease Management
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurological and metabolic disorders
Cornell University
2023-2025
Weill Cornell Medicine
2023-2025
Background/Objectives: Accurate and reproducible spleen volume measurements are essential for assessing treatment response disease progression in myelofibrosis. This study evaluates techniques measuring on abdominal MRI. Methods: In 20 patients with bone marrow biopsy-proven myelofibrosis, 5 observers independently measured 3 MRI pulse sequences, 3D-spoiled gradient echo T1, axial single-shot fast spin (SSFSE) T2, coronal SSFSE using ellipsoidal approximation, manual contouring, 3D nnU-Net...
Background/Objectives: Although tolvaptan efficacy in ADPKD has been demonstrated randomized clinical trials, there is no definitive method for assessing its the individual patient setting. In this exploratory feasibility study, we report a to quantify change total kidney volume (TKV) growth rate retrospectively evaluate patients. Treatment-related changes estimated glomerular filtration (eGFR) are also assessed. Methods: MRI scans covering at least 1 year prior and during treatment with...
Total kidney volume measured on MRI is an important biomarker for assessing the progression of autosomal dominant polycystic disease and response to treatment. However, we have noticed that there can be substantial differences in measurements obtained from various pulse sequences commonly included exam. Here examine measurement variability among five acquired abdominal exams 105 patients with ADPKD. Right left volumes were independently by three expert observers using model-assisted...
Abstract Mayo Imaging Classification (MIC) for predicting future kidney growth in autosomal dominant polycystic disease (ADPKD) patients is calculated from a single MRI/CT scan assuming exponential volume and height-adjusted total at birth to be 150 mL/m. However, when multiple scans are available, how this information should combined improve prediction accuracy unclear. Herein, we studied ADPKD subjects ( $$n = 36$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow>...
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) can lead to liver (PLD), characterized by cysts. Although majority of the patients are asymptomatic, massively enlarged secondary PLD cause discomfort, and compression on adjacent structures requiring cyst aspiration/fenestration, partial resection, or transplantation. Monitoring measuring volume fails track early stages when is too small affect volume. Purpose To improve assessment in automating detection segmentation...
Abdominal imaging of autosomal dominant polycystic kidney disease (ADPKD) has historically focused on detecting complications such as cyst rupture, infection, obstructing renal calculi, and pyelonephritis; discriminating complex cysts from cell carcinoma; identifying sources abdominal pain. Many features ADPKD are incompletely evaluated or not deemed to be clinically significant, because this, treatment options limited. However, total volume (TKV) measurement become important for assessing...
Background: Pancreatic cysts in autosomal dominant polycystic kidney disease (ADPKD) correlate with PKD2 mutations, which have a different phenotype than PKD1 mutations. However, pancreatic are commonly overlooked by radiologists. Here, we automate the detection of on abdominal MRI ADPKD. Methods: Eight nnU-Net-based segmentation models 2D or 3D configuration and various loss functions were trained positive-only positive-and-negative datasets, comprising axial coronal T2-weighted MR images...
Total kidney volume (TKV) is a critical biomarker for monitoring disease severity in autosomal dominant polycystic (ADPKD). TKV typically measured by manually contouring kidneys on one sequence from abdominal MRI without any quality control. Here we show that using deep learning model to measure 5 routinely acquired sequences, it possible apply outlier analysis find images with acquisition artifacts and correct or exclude them estimation. This improves measurement consistency among the...
Motivation: By measuring height-adjusted total kidney volume (ht-TKV), renal MRI monitors autosomal dominant polycystic disease (ADPKD) progression and evaluates therapeutic interventions&rsquo; efficacy for slowing cyst growth. Goal(s): Since arginine vasopressin (AVP) stimulates growth, reducing with high-water intake (HWI) may slow ADPKD progression. Approach: We test this hypothesis using a case-crossover study 7 subjects, ht-TKV changes on during usual intake. Results: High-water...
Motivation: Abdominal organ volumes are critical MRI biomarkers in many diseases including autosomal dominant polycystic kidney disease. Goal(s): We aim to develop a segmentation model with an enhanced ability generalize across various abdominal organs and MR pulse sequences. Approach: construct multi-modality foundation expanding upon our existing ADPKD which adapts diverse tissues minimal new training data. Results: The was trained using model-in-loop methodology evaluated against...
Motivation: Height-adjusted total kidney volume (htTKV) growth rate measured on MRI or CT is a critical biomarker for monitoring autosomal dominant polycystic disease (ADPKD) progression. Goal(s): This study aims to develop tool accurate calculation of the htTKV based all available scans. Approach: Accuracy four methods calculating were assessed as compared ground truth calculated from 10+ years imaging follow up. Results: Using 2-parameter least squares fitting with 3+ scans 5+ up reduce...