A5062657294- Microbial Metabolism and Applications
- Antibiotic Resistance in Bacteria
- Biofuel production and bioconversion
- Antibiotics Pharmacokinetics and Efficacy
- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
- Microbial Natural Products and Biosynthesis
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Molecular Biology Techniques and Applications
- Algal biology and biofuel production
- Antibiotic Use and Resistance
- Protist diversity and phylogeny
- Plant Pathogens and Fungal Diseases
- Vibrio bacteria research studies
- Protein Hydrolysis and Bioactive Peptides
- Enzyme Production and Characterization
- Cardiovascular Function and Risk Factors
- Fermentation and Sensory Analysis
- Machine Learning in Bioinformatics
- Tuberculosis Research and Epidemiology
- Pharmaceutical and Antibiotic Environmental Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
Autonomous University of Sinaloa
2025
Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés
2014-2019
Université de Toulouse
2014-2019
Centre National de la Recherche Scientifique
2014-2019
Université Toulouse III - Paul Sabatier
2014
University of Nottingham
2014
A critical step in the RT-qPCR workflow for studying gene expression is data normalization, one of strategies being use reference genes. This study aimed to identify and validate a selection genes relative quantification Talaromyces versatilis, relevant industrial filamentous fungus. Beyond T. this also propose that are applicable more widely normalization fungi. stable, potential was carried out silico from RNA-seq based transcriptomic obtained versatilis. dozen functionally unrelated...
LasB elastase is a broad-spectrum exoprotease and key virulence factor of Pseudomonas aeruginosa, major pathogen causing lung damage inflammation in acute chronic respiratory infections. Here, we describe the chemical optimization specific inhibitors with druglike properties investigate their impact cellular animal models P. aeruginosa infection. Competitive inhibition was demonstrated through structural kinetic studies. In vitro confirmed respect to several host target proteins, namely,...
The global dissemination of metallo-β-lactamase (MBL)-producing carbapenem-resistant Enterobacterales (CRE) is a serious public health concern. Specifically, NDM (New Delhi MBL) has been major cause carbapenem therapy failures in recent years, particularly as effective treatments for serine-β-lactamase (SBL)-producing are now commercially available.
ANT3310 is a novel broad-spectrum diazabicyclooctane serine β-lactamase inhibitor being developed in combination with meropenem (MEM) for the treatment of serious infections hospitalized patients where carbapenem-resistant Gram-negative pathogens are expected. In this study, we evaluated
The diazabicyclooctanes (DBOs) are a class of serine β-lactamase (SBL) inhibitors that use strained urea moiety as the warhead to react with active residue in site SBLs. first in-class drug, avibactam, well several other recently approved DBOs (e.g., relebactam) or those clinical development nacubactam and zidebactam) potentiate activity β-lactam antibiotics, various extents, against carbapenem-resistant Enterobacterales (CRE) carrying A, C, D SBLs; however, none these able rescue...
Pseudomonas aeruginosa is a common pathogen in cystic fibrosis (CF) patients and major contributor to progressive lung damage. P. elastase (LasB), key virulence factor, has been identified as potential target for anti-virulence therapy. Here, we sought differentiate the isolates from early versus established stages of infection CF determine if LasB was associated with either stage. The lasB gene amplified 255 clinical 70 Toulouse region (France). Nine variants were 69% produced detectable...
ABSTRACT In this article, we present a method to delete genes in filamentous fungi that allows recycling of the selection marker and is efficient nonhomologous end-joining (NHEJ)-proficient strain. We exemplify approach by deletion gene encoding transcriptional regulator XlnR fungus Aspergillus niger . To show efficiency advantages method, deleted 8 other constructed double mutant species. Moreover, showed same principle also functions different genus ( Talaromyces versatilis , basionym...
Research on filamentous fungi emphasized the remarkable redundancy in genes encoding hydrolytic enzymes, similarities but also large differences their expression, especially through role of XlnR/XYR1 transcriptional activator. The purpose this study was to evaluate specificities industrial fungus Talaromyces versatilis, getting clues into XlnR and importance glucose repression at level, provide further levers for cocktail production. By studying a set 62 redundant representative several...