A5039491528- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Bone and Joint Diseases
- Vestibular and auditory disorders
- Pentecostalism and Christianity Studies
- Chromosomal and Genetic Variations
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Diagnosis and Treatment
- Education and Islamic Studies
- Noise Effects and Management
- Peroxisome Proliferator-Activated Receptors
- Religious Education and Schools
- Gestational Diabetes Research and Management
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Religion, Society, and Development
- Islamic Finance and Banking Studies
- Bone health and treatments
- Birth, Development, and Health
- Infant Nutrition and Health
Yale University
2008-2024
OBJECTIVE The response of ventromedial hypothalamic (VMH) glucose-inhibited neurons to decreased glucose is impaired under conditions where the counterregulatory (CRR) hypoglycemia (e.g., recurrent hypoglycemia). This suggests a role for in CRR. We recently showed that increases nitric oxide (NO) production cultured VMH neurons. These vitro data led us hypothesize NO release from critical RESEARCH DESIGN AND METHODS CRR was evaluated rats and mice acute insulin-induced hypoglycemic clamps...
Insulin-induced hypoglycemia in diabetes is associated with impaired glucagon secretion. In this study, we tested whether stimulation of GPR119, a G-protein–coupled receptor expressed pancreatic islet as well enteroendocrine cells and previously shown to stimulate insulin incretin secretion, might enhance secretion during hypoglycemia. the GPR119 agonists were applied isolated islets or perfused pancreata assess hypoglycemic hyperglycemic conditions. Insulin infusion clamps performed without...
GABBR1 and GABBR2 are widely expressed in the brain genetic inhibition of their function leads to widespread neurologic dysfunction premature death mice. Given that heterodimerize form a functional receptor, global knockout or results similar phenotype, characterized by spontaneous epileptiform activity, hyperlocomotor hyperalgesia, impaired memory death. It is now known both variety tissues outside nervous system GABA-B receptors can with other class C GPCRs, including extracellular...
ABSTRACT Hypercalcemia, caused by tumor secretion of parathyroid hormone-related protein (PTHrP), is associated with anorexia and weight loss. We demonstrate that overexpression PTHrP cells in a transgenic model breast cancer causes rapid These changes are accompanied activation neurons the area postrema (AP), nucleus tractus solitarius (NTS) parabrachial (PBN), hindbrain circuit regulating food intake. Blocking hypercalcemia prevents these brain centers bearing mice, whereas injecting...
Abstract Disclosure: J.R. Hens: None. Y. Ding: S. Brown: H. Song: J.J. Wysolmerski: R. Belfort De Aguiar: A history of lactation significantly lowers the risk developing Type 2 diabetes (T2D) by almost 50%. However, little is known about how milk production durably changes maternal metabolism. We hypothesized that protects against improving glucose Changes in body composition, metabolism, insulin secretion and tissue triglyceride levels were measured age-matched cohorts mice lactated (L) or...