A5009507517- Traditional Chinese Medicine Studies
- COVID-19 epidemiological studies
- Atherosclerosis and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Antioxidant Activity and Oxidative Stress
- Glycosylation and Glycoproteins Research
- Healthcare Systems and Reforms
- Caveolin-1 and cellular processes
- Lipid metabolism and disorders
- Cell Adhesion Molecules Research
- Lipoproteins and Cardiovascular Health
- Advanced Photocatalysis Techniques
- Advanced Nanomaterials in Catalysis
- Healthcare and Venom Research
- Protease and Inhibitor Mechanisms
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Viral Infections and Outbreaks Research
- Plant-based Medicinal Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Erythrocyte Function and Pathophysiology
- Medical Research and Treatments
- Pharmacological Effects of Natural Compounds
- Estrogen and related hormone effects
- Acupuncture Treatment Research Studies
Jiangxi University of Traditional Chinese Medicine
2014-2024
Nanchang University
2014-2019
Summary Objective This study sought to systematically compare the efficacy and mechanism of cyclodextrins as drug interventions in lipid metabolism diseases, potentially providing ideas for subsequent research directions clinical applications. Methods We used bibliometric method feature mining, applied VOSviewer software clustering analysis, content analysis objective descriptions accurate analysis. Results (1) collected more than 50 studies, which is basic database this study. (2) The...
The size and biomechanical properties of lipoproteins are tightly correlated with their structures/functions. While atomic force microscopy (AFM) has been used to image the measurement these nano-sized particles is missing. We detected that sizes LDL HDL in liquid close commonly known values. Young's modulus or ∼0.4 GPa which similar some viral capsids nanovesicles but greatly larger than various liposomes. adhesive small (∼200 pN). comparison AFM detection air was also performed currently...
Due to its powerful ability deplete cholesterol from the plasma membrane of cells, methyl-β-cyclodextrin (MβCD) has been widely used as a putative research tool in cell biology. Recently, recruiting MβCD an effective drug (e.g., antitumor drugs) developed. However, it remains unclear whether MβCD, when enters blood circulation drug, influences functions endothelium, e.g., adhesion leukocytes endothelium. In this study, we found that can impair monocytes monolayer endothelial cells by...
While most attention has been focused on physiologically generated blebs, the molecular mechanisms for fixation‐induced cell blebbing are less investigated. We show that protein‐fixing (e.g. aldehydes and picric acid) but not lipid‐stabilizing OsO 4 KMnO ) fixatives induce spread cells. also aldehyde fixation may loss or delocalization of phosphatidylinositol 4,5‐bisphosphate (PIP 2 in plasma membrane asymmetric distribution blebs spread/migrating cells coincides with PIP prefixed by (e.g.,...
Recently, the atheroprotective role of endogenous GM3 and an atherogenesis-inhibiting effect exogenous suggested a possibility being recruited as anti-atherosclerotic drug. This study seeks to endow with atherosclerotic targetability via reconstituted high-density lipoprotein (rHDL), targeting drug nanocarrier. Unloaded rHDL, rHDL loaded at low concentration (GM3L-rHDL), carrying relatively high (GM3H-rHDL) were prepared characterized. The inhibitory GM3-rHDL on lipid deposition in...
Previously, we found that exogenous ganglioside GM3 had an antiatherosclerotic efficacy and its could be enhanced by reconstituted high-density lipoprotein (rHDL). In this study, hypothesized GM3-functionalized rHDL (i.e., GM3-rHDL) as a nanocarrier can promote the of traditional drugs (e.g., statins). To test hypothesis, lovastatin (LT) was used representative statins, LT-loaded GM3-rHDL nanoparticle (LT-GM3-rHDL or LT@GM3-rHDL; mean size ~142 nm) multiple controls without LT, LT-rHDL,...
Beta-cyclodextrin (β-CD) has been applied as drug/food carriers or potential drugs for treating some diseases. Most recently, evidence indicated that methyl-β-cyclodextrin (MβCD) and 2-hydroxypropyl-β-cyclodextrin (2-HPβCD), two major derivatives of β-CD, may inhibit atherogenesis, implying cyclodextrins also can be atherosclerosis. It is well known modification (e.g. oxidation) low-density lipoprotein (LDL) one the most critical steps atherogenesis. Lipoxygenase, an enzyme able to expressed...
Introduction: Precocious puberty is one of endocrine diseases. Based on clinical research perspectives, this study compares and analyses the characteristics advantages different types intervention protocols for treatment precocious to provide references their applications. Methods: Through bibliometric method, IBM SPSS Moderler18 software via VOS viewer analyze relevant data.Results: A total 194 literatures were obtained through systematic retrieval sorting, which divided into three...