A5035315338- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Covalent Organic Framework Applications
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Sexual Differentiation and Disorders
- Machine Learning in Materials Science
- Carbon dioxide utilization in catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Effects and risks of endocrine disrupting chemicals
- Catalytic Processes in Materials Science
- Estrogen and related hormone effects
- Sperm and Testicular Function
- Supramolecular Self-Assembly in Materials
- Radioactive element chemistry and processing
- Carbon Dioxide Capture Technologies
- Steroid Chemistry and Biochemistry
- Adrenal Hormones and Disorders
- Pesticide Exposure and Toxicity
Indiana University Bloomington
2023-2025
Indiana University
2024-2025
University of Delaware
2017-2024
University of California, Berkeley
2013-2023
Center for Innovation
2023
Harvard University
1956-2022
Newark Hospital
2020-2021
Harvard University Press
2018
Berkeley College
2015-2018
University of California System
2015-2017
Analysis of the CO2 adsorption properties a well-known series metal–organic frameworks M2(dobdc) (dobdc4− = 2,5-dioxido-1,4-benzenedicarboxylate; M Mg, Mn, Fe, Co, Ni, Cu, and Zn) is carried out in tandem with situ structural studies to identify host–guest interactions that lead significant differences isosteric heats adsorption. Neutron X-ray powder diffraction single crystal experiments are used unveil site-specific binding within many these materials while systematically varying both...
Abstract A mixed‐linker solid‐solution approach was employed to modify the metal sites and introduce structural defects into mixed‐valence Ru II/III analogue of well‐known MOF family [M 3 II,II (btc) 2 ] (M=Cu, Mo, Cr, Ni, Zn; btc=benzene‐1,3,5‐tricarboxylate), with partly missing carboxylate ligators at paddle‐wheels. Incorporation pyridine‐3,5‐dicarboxylate (pydc), which is same size as btc but carries lower charge, a second, defective linker has led isoreticular derivatives Ru‐MOF,...
Six metal-organic frameworks of the M2(dobdc) (M = Mg, Mn, Fe, Co, Ni, Zn; dobdc(4-) 2,5-dioxido-1,4-benzenedicarboxylate) structure type are demonstrated to bind carbon monoxide reversibly and at high capacity. Infrared spectra indicate that, upon coordination CO divalent metal cations lining pores within these frameworks, C-O stretching frequency is blue-shifted, consistent with nonclassical metal-CO interactions. Structure determinations reveal M-CO distances ranging from 2.09(2) Å for M...
The hydrogen storage properties of a new family isostructural metal–organic frameworks are reported. M2(dobpdc) (M = Mg, Mn, Fe, Co, Ni, Zn; dobpdc4– 4,4′-dioxidobiphenyl-3,3′-dicarboxylate) analogous to the widely studied M2(dobdc) Cu, dobdc4– 2,5-dioxido-1,4-benzenedicarboxylate) materials, featuring same weak-field oxo-based ligand environment for M2+ metal centers, but with larger pore volume resulting from extended length linker. Hydrogen gas adsorption isotherms measured at 77 and 87 K...
Purification of the C8 alkylaromatics o-xylene, m-xylene, p-xylene, and ethylbenzene remains among most challenging industrial separations, due to similar shapes, boiling points, polarities these molecules. Herein, we report evaluation metal-organic frameworks Co2(dobdc) (dobdc4- = 2,5-dioxido-1,4-benzenedicarboxylate) Co2( m-dobdc) ( m-dobdc4- 4,6-dioxido-1,3-benzenedicarboxylate) for separation xylene isomers using single-component adsorption isotherms multicomponent breakthrough...
Metal–organic frameworks featuring ligands with open chelating groups are versatile platforms for the preparation of a diverse set heterogeneous catalysts through postsynthetic metalation. The crystalline nature these materials allows them to be characterized via X-ray diffraction, which provides valuable insight into structure metal sites that facilitate catalysis. A highly porous and thermally robust zirconium-based metal–organic framework, Zr6O4(OH)4(bpydc)6 (bpydc2– =...
Gas separations with porous materials are economically important and provide a unique challenge to fundamental design, as adsorbent properties can be altered achieve selective gas adsorption. Metal-organic frameworks represent rapidly expanding new class of adsorbents large range possibilities for designing desired functionalities. Given the number possible framework structures, quantum mechanical computations useful guidance in prioritizing synthesis most given application. Here, we show...
Developing novel drug carriers for pulmonary delivery is necessary to achieve higher efficacy and consistency treating diseases while limiting off-target side effects that occur from alternative routes of administration. Metal–organic frameworks (MOFs) have recently emerged as a class materials with characteristics well-suited delivery, chemical tunability, high surface area, pore size, which will allow efficient loading therapeutic cargo deep lung penetration. UiO-66, zirconium terephthalic...
Although gas adsorption properties of extended three-dimensional metal-organic materials have been widely studied, they remain relatively unexplored in porous molecular systems. This is particularly the case for coordination cages which surface areas are typically not reported. Herein, we report synthesis, characterization, activation, and a family carbazole-based cages. The chromium analog displays cage record BET (Brunauer-Emmett-Teller) area 1235 m2/g. With precise synthesis activation...
Porous molecular solids are promising materials for gas storage and separation applications. However, given the relative dearth of structural information concerning these materials, additional studies vital further understanding their properties developing design parameters optimization. Here, we examine a series isostructural cuboctahedral, paddlewheel-based coordination cages, M24(tBu-bdc)24 (M = Cr, Mo, Ru; tBu-bdc2– 5-tert-butylisophthalate), high-pressure methane storage. As decrease in...
Metal–organic frameworks and porous coordination cages have shown incredible promise as a result of their high tunability. However, syntheses pursuing precisely targeted mixed functionalities, such multiple ligand types or mixed-metal compositions are often serendipitous, require postsynthetic modification strategies, based on complex design. Herein, we present new method for the controlled synthesis functionality metal–organic materials via preparation salts. More specifically, combination...
Abstract The adoption of pulmonary vaccines to advantageously provide superior local mucosal protection against aerosolized pathogens has been faced with numerous logistical and practical challenges. One these persistent challenges is the lack effective vaccine adjuvants that could be well tolerated through inhaled route administration. Despite its widespread use as a adjuvant, aluminum salts (alum) are not in lung. To address this issue, we evaluated porous (Al)-based metal–organic...
Homogenates of testes and ovaries, obtained from human fetuses at 9–11, 12–15 19 weeks gestational age, were incubated with 4-14C-progesterone. The media the individual incubations combined into groups according to sex analyzed for conversion products progesterone by reverse isotope dilution technique. Testes tissue converted testosterone, 17α-hydroxyprogesterone (a major metabolite) 16α-hydroxyprogesterone. Testosterone synthesis older (12–15 weeks) was least 7-fold that younger tissue. In...
<italic>In situ</italic> single-crystal X-ray diffraction experiments enable the direct observation of weak metal–gas interactions in a metal–organic framework.
Abstract The ground state electronic structure of copper corroles has been a topic debate and revision since the advent corrole chemistry. Computational studies formulate neutral Cu with an antiferromagnetically coupled II radical cation state. X‐ray photoelectron spectroscopy, EPR, magnetometry support this assignment. For comparison, isocorrole [TBA][Cu(CF 3 ) 4 ] were studied as authentic III samples, respectively. In addition, one‐electron reduction oxidation processes are both...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSelective Gas Adsorption in Highly Porous Chromium(II)-Based Metal–Organic PolyhedraGregory R. Lorzing†⊥, Benjamin A. Trump‡, Craig M. Brown‡§, and Eric D. Bloch*†⊥View Author Information† Department of Chemistry Biochemistry, University Delaware, Newark, Delaware 19716, United States⊥ Center for Neutron Science, Chemical Biomolecular Engineering, States‡ Research, National Institute Standards Technology, Gaithersburg, Maryland 20899, States§...
A thorough experimental and computational study has been carried out to elucidate the mechanistic reasons for high volumetric uptake of methane in metal-organic framework Cu3(btc)2 (btc(3-) = 1,3,5-benzenetricarboxylate; HKUST-1). Methane adsorption data measured at several temperatures Cu3(btc)2, its isostructural analogue Cr3(btc)2, show that there is little difference capacity when metal center changed. In situ neutron powder diffraction obtained both materials were used locate four CD4...
UiO-66, a zirconium(IV) metal-organic framework (MOF) comprised of six-metal clusters and terephthalic acid ligands, displays excellent thermal chemical stability has functions in gas storage, catalysis, selective adsorption, drug delivery. Though the UiO-66 is highly advantageous, simultaneous synthetic control over particle size defectiveness remains difficult to attain. Using an acid-free solvothermal synthesis, we demonstrate that size, defectiveness, inherent fluorescence can be...
THE unusually large size of the adrenal glands human fetus (Figs. 1, 2) and their rapid partial involution have been subject numerous reports investigations. Lanman (1953) contributed an admirable summary all known details concerning development probable function this gland in developing added a valuable comparative anatomic study adrenals other animals. While wealth contributions to literature is cited by (19.53), his conclusion that little definite regarding actual physiology unborn fetus....
The molecular nature of porous coordination cages can endow these materials with significant advantages as compared to extended network solids. Chiefly among is their solubility in volatile solvents, which be leveraged the synthesis, characterization, modification, and utilization adsorbents. Although cuboctahedral, paddlewheel-based have shown some highest surface areas for cages, they often limited solubility. Here, we show that amide ester functionalization, has been widely utilized...