Embora no Brasil o número de casos confirmados febre maculosa esteja em declínio desde 2005, a taxa mortalidade (20 30%) ainda é muito alta quando comparada outros países. Esse alto índice tem estreita relação com dificuldade fazer diagnóstico e estabelecer terapia apropriada. Apenas dois grupos antibióticos têm comprovada eficácia clínica, cloranfenicol as tetraciclinas. Até pouco tempo atrás, tetraciclinas eram reservadas aos pacientes adultos virtude das alterações dentárias ósseas...

The aim of this study was to identify and quantify risk factors for amputation in diabetic patients hospitalized foot infections. This cross-sectional comprised 100 with infectious complications the lower limbs. variables investigated were related diabetes, infection, treatment compliance. Multiple Cox regression analysis performed independently associated outcome amputation. most prevalent chronic neuropathy hypertension. Most presented a neuroischemic (86%). Morisky test showed that 72%...

INTRODUÇÃO: O objetivo deste estudo foi conhecer os padrões de utilização antibióticos no município Sorocaba, avaliando o diagnóstico referido, a terapêutica empregada e sua utilização. MÉTODOS: Utilizou-se um instrumento avaliação aplicado por 12 meses em usuários antibióticos. Foram coletados dados 403 referiram-se à: informações sociodemográficas saúde, terapêutica. RESULTADOS: Encontrou-se grande maior prévia na faixa etária 0-10 anos (p<0,05). As infecções com envolvimento pulmonar...

The increased effectiveness of antiretroviral therapy (ART) in the last 30 years is a scientific landmark, and viral suppression directly associated with treatment adherence. aim this study was to compare results ART adherence load evolution protocols other factors, people living HIV. A panel analysis three descriptive longitudinal studies investigating conducted HIV treated at drug dispensing unit Federal District. were carried out during periods 2011, 2013, 2017, coinciding different...

In 2011, private pharmacies associated to the Brazilian Ministry of Health provided patients with two types insulin (regular human and isophane or NPH) three oral antidiabetic medications (5 mg glibenclamide 500 850 metformin) free charge. The aim was evaluate impact "Health Has No Price" Program [Saúde Não Tem Preço (SNTP)] for access diabetes treatment medicines in Brazil. This longitudinal observational study is based on number units hypoglycemic agents, analogues supplied 55,000 from...

The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services Brazil, which usually adopts protocols based on published studies. trials are controversial, and several have been conducted with current dialyzers. This study aimed at assessing the suitability of concentrations HD a public hospital. Blood samples were collected from November 2006 to May 2007, time intervals 48, 96,...

No Brasil o PBM (Pharmacy Benefits Management) é de utilização relativamente nova, podendo-se classificá-lo como um sistema gerenciamento saúde que administra benefícios na compra e venda medicamentos. Considerando surgimento bactérias resistentes está relacionado à prescrição inapropriada antibióticos ou ao uso baixa atividade, este estudo avaliou se pode fornecer informações úteis sobre os perfis aquisição efeitos sistêmicos, a partir da base dados uma empresa brasileira, referente grupo...

Establishing an effective antimicrobial therapeutic requires choosing the appropriate antibiotic and ensuring compliance with times doses prescribed. Problems concerning early abandonment unfinished prescriptions due to lack of information, as well more resistant microorganisms, have been identified major factors responsible for failure in bacterial infections. This study aimed determine level information among users undergoing treatment these drugs, habits related other therapies. A survey...

The toxicity of a hydroethanol extract the subterranean part Cochlospermum regium was evaluated in mice and rats. had moderate acute when administered intraperitoneally low upon oral administration. A subacute test revealed that is well tolerated by these animals.

INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil's Federal District. METHODS: Medical records were analyzed and ADRs categorized by type, intensity, seriousness, causality. RESULTS: Of 62 patients who started treatment CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued treatment. Most classified as probable (81%), severe (63%), serious...

Despite the therapeutic benefits of drugs, adverse drug reactions (ADRs) occur. Method: We assessed a series suspected ADRs identified from notifications and intensive monitoring inpatients March 2013 to 2014.Skin predominated (31%). Systemic anti-infective agents were implicated in 16 (72%) reactions. Fifteen (68%) classified as possible. The was not correctly by healthcare team 12 cases.Some attributed causative drug(s), suggesting that use validated evaluation method can promote...

Na pandemia da covid-19 muitos medicamentos sem evidências foram utilizados para prevenção e tratamento. Neste contexto, o objetivo deste estudo foi analisar a comercialização de antigripais no Brasil, antes durante covid-19, descrevendo série histórica comparando seus resultados. Trata-se um utilização medicamentos, do tipo observacional ecológico descritivo quantitativo, realizado partir dados secundários consolidados Sistema Acompanhamento Mercado Medicamentos Agência Nacional Vigilância...

Uma transfusão de sangue com o tipo ABO incorreto pode resultar na morte do paciente, reação hemolítica intravascular, seguida alterações imunológicas e bioquímicas. Considerando a pequena quantidade estudos sobre as hemolisinas anti-A anti-B importância desses anticorpos prática transfusional, objetivo deste trabalho foi verificar frequência dessas associação fatores como etnia gênero em doadores dos bancos municípios Itapeva Ourinhos, no interior estado São Paulo. Foram analisadas todas...

The effectiveness of antiretroviral therapy has rendered HIV infection a manageable chronic condition. Currently, the health systems face challenge adopting organizational healthcare models capable ensuring delivery comprehensive care. Chronic Care Model been reported for its effectiveness, particularly in terms system design. In this study, Assessment Illness (ACIC) questionnaire, soft technology widely used other conditions, was employed on teaching hospital to evaluate provided people...

Introduction: The frequency of adverse events is high in hospitals and this context supported the elaboration goals, whose execution involves hospital pharmacy (HP). Objective: To evaluate HP’s participation risk management medication use 15 public Federal District (Brazil). Method: Cross-sectional study data collection was performed from May to November 2016 involved characterization hierarchization, HP evaluation according indicators related medicines calculation percentages compliance...

Purpose: The aim of the present study was to determine whether de-escalation guided by blood cultures for patients with a diagnosis sepsis, severe sepsis or septic shock reduces mortality, and antimicrobial drug resistance (ADR). Methods: A prospective, single-center, cohort conducted adults admitted ICU at public hospital in Sorocaba, State São Paulo, Brazil, from January 2013 December 2013. We excluded who had negative cultures. Patients replaced initial empirical broad-spectrum antibiotic...

Abstract Background Brazil, like many Latin American countries, has struggled with the inappropriate use of antibiotics in community without a prescription form physician. Since November 2010, The Brazilian Health Surveillance Agency established stricter control antibiotic sales, which requires that copy prescriptions be retained by pharmacy for audit. Pharmacists now also have more severe civil and criminal liability if they allow sale prescription. aim this study was to analyze impact new...

The toxicity of a hydroethanol extract the subterranean part Cochlospermum regium was evaluated in mice and rats. had moderate acute when administered intraperitoneally low upon oral administration. A subacute test revealed that is well tolerated by these animals. Copyright © 2000 John Wiley & Sons, Ltd.