A5080328618- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Memory Processes and Influences
- Neuroscience and Music Perception
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Neural Networks and Applications
- Identity, Memory, and Therapy
- Tactile and Sensory Interactions
- Media Influence and Health
- Action Observation and Synchronization
- Neurobiology of Language and Bilingualism
- Misinformation and Its Impacts
- Child and Animal Learning Development
- Mental Health Research Topics
- Language, Metaphor, and Cognition
- Machine Learning in Materials Science
- Face Recognition and Perception
- Multisensory perception and integration
- Music and Audio Processing
- Visual Attention and Saliency Detection
- Machine Learning in Healthcare
Johns Hopkins University
2016-2024
Indiana University Bloomington
2024
Pennsylvania State University
2022
University of Oregon
2022
Princeton University
2013-2018
Neuroscience Institute
2015-2017
University of Baltimore
2017
Stanford University
2009-2015
Jordan Hospital
2009
Abstract Does the default mode network (DMN) reconfigure to encode information about changing environment? This question has proven difficult, because patterns of functional connectivity reflect a mixture stimulus-induced neural processes, intrinsic processes and non-neuronal noise. Here we introduce inter-subject correlation (ISFC), which isolates stimulus-dependent inter-regional correlations between brains exposed same stimulus. During fMRI, had subjects listen real-life auditory...
Differences in people’s beliefs can substantially impact their interpretation of a series events. In this functional MRI study, we manipulated subjects’ beliefs, leading two groups subjects to interpret the same narrative different ways. We found that responses higher-order brain areas—including default-mode network, language areas, and subsets mirror neuron system—tended be similar among people who shared interpretation, but from those with an opposing interpretation. Furthermore,...
Hippocampal subfields CA 3 and 1 are hypothesized to differentially support the generation of associative predictions detection mismatches, respectively. Using high-resolution functional MRI, we examined hippocampal subfield activation during retrieval subsequent comparisons memory matching or mismatching decision probes. Activity in dentate gyrus/CA 2/3 , other medial temporal lobe subregions tracked success, whereas activity perirhinal cortex presence mismatches. These data hypothesis that...
What mechanisms support our ability to estimate durations on the order of minutes? Behavioral studies in humans have shown that changes contextual features lead overestimation past durations. Based evidence medial temporal lobes and prefrontal cortex represent features, we related degree fMRI pattern change these regions with people’s subsequent duration estimates. After listening a radio story scanner, participants were asked how much time had elapsed between pairs clips from story. Our ROI...
The "Narratives" collection aggregates a variety of functional MRI datasets collected while human subjects listened to naturalistic spoken stories. current release includes 345 subjects, 891 scans, and 27 diverse stories varying duration totaling ~4.6 hours unique stimuli (~43,000 words). This data is well-suited for neuroimaging analysis, intended serve as benchmark models language narrative comprehension. We provide standardized accompanied by rich metadata, preprocessed versions the ready...
The pulvinar influences communication between cortical areas. We use fMRI to characterize the functional organization of human and its coupling with cortex. ventral is sensitive spatial position moment-to-moment transitions in visual statistics, but also differentiates categories such as faces scenes. dorsal modulated by attention temporal structure input. Cortical areas are functionally coupled discrete regions. this reflects specializations anatomical distances occipital-temporal cortices....
Abstract How does attention route information from sensory to high-order areas as a function of task, within the relatively fixed topology brain? In this study, participants were simultaneously presented with 2 unrelated stories—one spoken and one written—and asked attend while ignoring other. We used fMRI novel intersubject correlation analysis track spread along processing hierarchy task. Processing unattended (written) was confined auditory (visual) cortices. contrast, attending story...
Abstract When we remember events, often do not only recall individual but also the connections between them. However, extant research has focused on how humans segment and discrete events from continuous input, with far less attention given to structure of impacts memory. Here conduct a functional magnetic resonance imaging study in which participants watch series realistic audiovisual narratives. By transforming narratives into networks demonstrate that more central events—those stronger...
The medial temporal lobe (MTL)-hippocampus and surrounding perirhinal, parahippocampal, entorhinal cortical areas-has long been known to be critical for long-term memory events. Recent functional neuroimaging neuropsychological data in humans performing short-delay tasks suggest that the MTL also contributes performance even when retention intervals are brief, single-unit rodents reveal sustained, performance-related delay activity during delayed-non-match-to-sample tasks. current study used...
Several research groups have shown how to map fMRI responses the meanings of presented stimuli. This paper presents new methods for doing so when only a natural language annotation is available as description stimulus. We study data gathered from subjects watching an episode BBCs Sherlock (Chen et al., 2017), and learn bidirectional mappings between representations. By leveraging multiple same movie, we were able perform scene classification with 72% accuracy (random guessing would give 4%)...
Significance Partisan biases in processing political information contribute to rising divisions society. How do such arise the brain? We measured neural activity of participants watching videos related immigration policy. Despite same videos, conservative and liberal exhibited divergent responses. This “neural polarization” between groups occurred a brain area associated with interpretation narrative content intensified response language risk, emotion, morality. Furthermore, polarized...
The posterior medial network is at the apex of a temporal integration hierarchy in brain, integrating information over many seconds viewing intact, but not scrambled, movies. This has been interpreted as an effect structure. Such structure movies depends on preexisting event schemas, can also arise de novo from learning. Here, we examined relative role schema-consistent and arbitrary consistent human network. We tested whether, with repeated viewing, becomes engaged by scrambled Replicating...
Abstract Recent fMRI studies of event segmentation have found that default mode regions represent high-level structure during movie watching. In these regions, neural patterns are relatively stable events and shift at boundaries. Music, like narratives, contains hierarchical (e.g., sections composed phrases). Here, we tested the hypothesis brain activity in reflect music. We used to record from 25 participants (male female) as they listened a continuous playlist 16 musical excerpts...
The brain actively reshapes our understanding of past events in light new incoming information. In the current study, we ask how supports this updating process during encoding and recall naturalistic stimuli. One group participants watched a movie (‘The Sixth Sense’) with cinematic ‘twist’ at end that dramatically changed interpretation previous events. Next, were asked to verbally events, taking into account Most updated their incorporate twist. Two additional groups recalled without having...
Pioneering advances in genome engineering, and specifically writing, have revolutionized the field of synthetic biology, propelling us toward creation genomes. The Sc2.0 project aims to build first fully eukaryotic organism by assembling Saccharomyces cerevisiae. With completion chromosome VIII (synVIII) described here, this goal is within reach. In addition writing yeast genome, we sought manipulate an essential functional element: point centromere. By relocating native centromere sequence...
Recognizing and remembering social information is a crucial cognitive skill. Neural patterns in the superior temporal sulcus (STS) support our ability to perceive others' interactions. However, despite prominence of interactions memory, neural basis still unknown. To fill this gap, we investigated brain mechanisms underlying memory during free spoken recall naturalistic movie. By applying machine learning-based fMRI encoding analyses densely labeled movie data found that subset STS activity...
Significance Over the past decade, human posterior parietal cortex (PPC) has been unexpectedly implicated in remembering and memory-related decision making. Functional neuroimaging indicates that responses differ across PPC, patients with PPC lesions show subtle to significant changes memory behavior. These surprising observations have motivated novel theorizing, yet current understanding of contributions is limited by absence temporal information about activity subregions as retrieval...
Emerging human, animal, and computational evidence suggest that, within the hippocampus, stored memories are compared with current sensory input to compute novelty, i.e., detecting when inputs deviate from expectations. Hippocampal subfield CA1 is thought detect mismatches between past present, detected novelty modulate encoding processes, providing a mechanism for gating entry of information into memory. Using high-resolution functional MRI, we examined human hippocampal medial temporal...
Summary During realistic, continuous perception, humans automatically segment experiences into discrete events. Using a novel model of neural event dynamics, we investigate how cortical structures generate representations during narratives, and these events are stored retrieved from long-term memory. Our data-driven approach enables identification boundaries correspondences across datasets without human-generated stimulus annotations, reveals that different regions narratives at timescales....