A5042120331- Radical Photochemical Reactions
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Crystallization and Solubility Studies
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- DNA and Nucleic Acid Chemistry
- Catalytic Cross-Coupling Reactions
- RNA modifications and cancer
- Cyclopropane Reaction Mechanisms
- RNA and protein synthesis mechanisms
- Sulfur-Based Synthesis Techniques
- Coordination Chemistry and Organometallics
University of Cambridge
2019-2020
AstraZeneca (United Kingdom)
2019-2020
University of Huddersfield
2016-2019
We report a general visible-light-mediated strategy that enables the construction of complex C(sp3)-rich N-heterospirocycles from feedstock aliphatic ketones and aldehydes with broad selection alkene-containing secondary amines. Key to success this approach was utilization highly reducing Ir-photocatalyst orchestration intrinsic reactivities 1,4-cyclohexadiene Hantzsch ester. This methodology provides streamlined access displaying structural functional features relevant fragment-based lead...
Abstract A new application of Pd‐catalysed allylation is reported that enables the synthesis a range branched sp 3 ‐functionalised sulfonamides, compound class for which few methods exist. By reacting benzyl sulfonamides with allylic acetates in presence Pd 0 catalysts and base at room temperature, direct was efficiently performed, yielding products are analogues structural motifs seen biologically active small molecules. The reaction performed under mild conditions could be applied to...
Anhydrouridines react with aliphatic amines to give N-alkyl isocytosines, but reported procedures often demand very long reaction times and can be low yielding, narrow scope. A modified procedure for such reactions has been developed, using microwave irradiation, significantly reducing time allowing facile access a diverse range of novel nucleosides on the gram scale. The method used prepare precursor analogue lysidine, naturally occurring iminonucleoside found in tRNA.