A5066249220- Advanced NMR Techniques and Applications
- Solid-state spectroscopy and crystallography
- Molecular spectroscopy and chirality
- Electron Spin Resonance Studies
- Chronic Kidney Disease and Diabetes
- Amino Acid Enzymes and Metabolism
- Advanced Glycation End Products research
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Various Chemistry Research Topics
- Enzyme Structure and Function
- NMR spectroscopy and applications
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
2024
Université Paris Sciences et Lettres
2022-2024
École Normale Supérieure - PSL
2022-2024
Laboratoire des Biomolécules
2024
Centre National de la Recherche Scientifique
2024
Sorbonne Université
2024
In nuclear magnetic resonance (NMR), the lifetimes of long-lived states (LLSs) are exquisitely sensitive to their environment. However, number molecules where such can be excited has hitherto been rather limited. Here, it is shown that LLSs readily in many common contain two or more neighboring CH 2 groups. Accessing does not require any isotopic enrichment, nor stereogenic centers lift chemical equivalence protons. were a variety metabolites, neurotransmitters, vitamins, amino acids, and...
Long-lived states (LLSs) have lifetimes
It is shown that proton spins highly polarized by dynamic nuclear polarization (DNP) retain substantial upon the rapid transfer of frozen bullets from a polarizer to an NMR spectrometer. After injection in solution, resulting hyperpolarization aliphatic chains comprises population imbalances between singlet and triplet states geminal protons combinations thereof. These hyperpolarized long-lived (LLSs) can be reconverted into observable transverse magnetization polychromatic spin-lock-induced...
It is shown that long-lived states (LLS) involving pairs of methylene protons in nuclear magnetic resonance (NMR) can be readily excited common molecules contain two or more neighboring CH$_2$ groups. Accessing such LLS does not require any isotopic enrichment, nor it stereogenic centers to lift the chemical equivalence protons. The excitation achieved by polychromatic spinlock-induced crossing (poly-SLIC). In a variety metabolites, neurotransmitters, vitamins, amino acids, and other...
The hyperpolarization of biological samples using dissolution-DNP has become an attractive method for the monitoring fast chemical and enzymatic reactions NMR by taking advantage large signal increase. This approach is actively developing, but still needs key methodological breakthroughs to be used as analytical complex networks simultaneous metabolic pathways. In this article, we use deceptively simple example G6P oxidation reaction enzyme dehydrogenase (G6PDH) discuss some important...
The hyperpolarization of biological samples using dissolution-DNP has become an attractive method for the monitoring fast chemical and enzymatic reactions NMR by taking advantage large signal increase. This approach is actively developing, but still needs key methodological breakthroughs to be used as analytical complex networks simultaneous metabolic pathways. In this article, we use deceptively simple example G6P oxidation reaction enzyme dehydrogenase (G6PDH) discuss some important...
The hyperpolarization of biological samples using dissolution-dynamic nuclear polarization (dDNP) has become an attractive method for the monitoring fast chemical and enzymatic reactions NMR by taking advantage large signal increase.This approach is actively developing, but still needs key methodological breakthroughs to be used as analytical complex networks simultaneous metabolic pathways.In this article, we use deceptively simple example glucose-6-phosphate (G6P) oxidation reaction enzyme...
Abstract. Long-lived states (LLS) have lifetimes TLLS that can be much longer than longitudinal relaxation times T1. In molecules containing several geminal pairs of protons in neighbouring CH2 groups, it has been shown delocalized long-lived excited by converting magnetization into imbalances between the populations singlet and triplet each pair. Since yield conversion observable LLS back are on order 10 % or less if one uses spin-locked induced crossing (SLIC), would desirable to boost...