A5023024177- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Biomedical Text Mining and Ontologies
- Electronic Health Records Systems
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacogenetics and Drug Metabolism
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Computational Drug Discovery Methods
- Tuberculosis Research and Epidemiology
- Healthcare Technology and Patient Monitoring
- Atrial Fibrillation Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Bariatric Surgery and Outcomes
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Epilepsy research and treatment
- Poisoning and overdose treatments
- Opioid Use Disorder Treatment
- Semantic Web and Ontologies
- Inflammatory mediators and NSAID effects
- Patient Safety and Medication Errors
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
University of Washington
2015-2024
Seattle University
2013-2023
Hershey (United States)
2023
Manhattan College
2010-2015
World Allergy Organization
2014
University of Washington Medical Center
1994-2012
La Jolla Bioengineering Institute
2007
Yale University
2006
University of Kentucky
2006
Stony Brook University
2005
The assessment of causation for a potential drug interaction requires thoughtful consideration the properties both object and precipitant drugs, patient-specific factors, possible contribution other drugs that patient may be taking. Naranjo nomogram was designed to evaluate single-drug adverse events, not drug-drug interactions. Several questions on do apply interactions, while others specify or drug. Nevertheless, it has been inappropriately used Drug Interaction Probability Scale (DIPS)...
Although potential drug–drug interactions (PDDIs) are a significant source of preventable drug-related harm, there is currently no single complete PDDI information. In the current study, all publically available sources information that could be identified using comprehensive and broad search were combined into dataset. The dataset merged fourteen different including 5 clinically-oriented sources, 4 Natural Language Processing (NLP) Corpora, Bioinformatics/Pharmacovigilance sources. As...
Abstract Antibodies to ribonucleoproteins (RNP) and the Sm antigen in sera from patients with mixed connective tissue disease (MCTD) systemic lupus erythematosus were studied using techniques of immunoblotting immunoprecipitation U small nuclear RNPs. A cross‐sectional study indicated that antibodies reacting a 68K protein associated anti‐RNP specificity MCTD, but rarely occurred patients' sera. longitudinal demonstrated persistence MCTD blotting patterns over many years, subsequent...
Human immunodeficiency virus 1 (HIV-1) protease inhibitors have dramatically reduced the morbidity and mortality due to HIV-1 infection. However, most of these antiretrovirals are also potent (and occasionally inducers) hepatic intestinal cytochrome P450 systems and, therefore, potential alter elimination any substance that utilizes metabolic pathways. We describe a patient infected with who was treated ritonavir saquinavir then experienced prolonged effect from small dose...
Ten healthy subjects received oral antipyrine and intravenous indocyanine green (ICG) alone after 5 days of nifedipine, diltiazem, verapamil. Antipyrine clearance decreased during verapamil (range 4% to 26%) diltiazem (6% 24%) therapy (P < 0.001) but did not change nifedipine treatment. t1/2 also increased treatment 0.001). ICG dosing with 0.05). Estimated liver blood flow (derived from hematocrit) (mean 33%) 27%) Drug interactions other liver-metabolized drugs may occur these calcium...
There is limited literature comparing the experiences and attitudes of patients with chronic idiopathic constipation (CIC) to those healthcare professionals (HCPs) treating CIC patients. The BURDEN-CIC study was conducted better understand ongoing needs assess their alignment versus disconnection perceptions HCPs who treat an author-developed, online questionnaire that used KnowledgePanel® survey individuals (n = 1223). were recruited separately participated in a complementary 331). Most had...
Colchicine has a narrow therapeutic index. Its toxicity can be increased due to concomitant exposure drugs inhibiting its metabolic pathway; these are cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).To examine clinical outcomes associated with colchicine drug interactions using the spontaneous reports of US Food Drug Administration (FDA) Adverse Event Reporting System (FAERS).We conducted disproportionality analysis FAERS data from January 2004 through June 2020. The reporting odds...
Four cases of warfarin-induced skin necrosis are reported, and previous reports this adverse drug reaction summarized. A 53-year-old man experienced two episodes on his left flank buttock, following the initiation warfarin therapy for acute thrombophlebitis after a dose adjustment. The lesion formed multiple hemorrhagic bullae that ruptured, an eschar did not heal eventually required grafting. Seven days therapy, area erythema surrounded by halo was noted thigh 79-year-old woman. Following...
Study Objectives To evaluate the effect of Roux‐en‐Y gastric bypass surgery ( RYGB ) on pharmacokinetics midazolam (a CYP 3A4 substrate) and digoxin P‐glycoprotein substrate). Design Prospective, nonblinded, longitudinal, single‐dose pharmacokinetic study in three phases: presurgery baseline postoperative assessments at 3 12 months. Patients Twelve obese patients meeting current standards for bariatric surgery. Measurements Main Results At each visit, received a single dose oral 8 a.m. Blood...
FigureINTRODUCTION This guideline on a World Digestive Health Day theme is the first to take 4 key gastrointestinal (GI) symptoms as its starting-point: heartburn, abdominal pain/discomfort, bloating, and constipation. It also unique in featuring levels of care cascade approach: self-care "over-the-counter (OTC)" aids; pharmacist's view; perspective primary doctor—wherein play role patient presentation; specialist. paper focuses 3 levels; algorithms for specialist can be found full version...
The BURDEN IBS-C study was conducted to better understand the experiences, attitudes, and unmet needs of sufferers irritable bowel syndrome with constipation (IBS-C) in comparison perceptions challenges healthcare providers (HCPs) who treat patients. This an author-developed, online questionnaire using KnowledgePanel® survey individuals (N = 1311). HCPs participated a complementary were recruited separately 331). fielded from June 29, 2016, January 30, 2017. Most patients had used (86%)...
Concurrent use of skeletal muscle relaxants (SMRs) and opioids has been linked to an increased risk injury. However, it remains unclear whether the injury risks differ by specific SMR when combined with opioids. We conducted nine retrospective cohort studies within a US Medicaid population. Each consisted exclusively person-time exposed both one three most dispensed opioids-hydrocodone, oxycodone, tramadol. Opioid users were further divided into cohorts based on initiation order SMRs...