A5101953744- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Cell Image Analysis Techniques
- 3D Printing in Biomedical Research
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
Dana-Farber Cancer Institute
2019-2020
Reproductive Science Center
2012
National Institute of Environmental Health Sciences
2012
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012
National Institutes of Health
2012
Center for Scientific Review
2012
Eisenhower Medical Center
2012
Ottawa Hospital
2012
Ottawa Hospital Research Institute
2012
Despite decades of effort, the sensitivity patient tumors to individual drugs is often not predictable on basis molecular markers alone. Therefore, unbiased, high-throughput approaches match effective drugs, without requiring a priori hypotheses, are critically needed. Here, we improved upon method that previously reported and developed called dynamic BH3 profiling (HT-DBP). HT-DBP microscopy-based, single-cell resolution assay enables chemical screens hundreds thousands candidate freshly...
Abstract Phenotypic differences between primary patient tumors and models of that are amenable to chemical screening represents a key barrier drug discovery repurposing. High-throughput technologies can accurately identify active drugs using therefore valuable additions the development toolbox may have direct clinical utility as predictive biomarkers. Here we report method called high-throughput dynamic BH3 profiling (HT-DBP), robust microscopy-based assay with single-cell resolution enables...
Phenotypic differences between primary patient tumors and models of that are amenable to chemical screening represents a key barrier drug discovery repurposing. High-throughput technologies can accurately identify active drugs using therefore valuable additions the development toolbox may have direct clinical utility as predictive biomarkers. Here we report method called high-throughput dynamic BH3 profiling (HT-DBP), robust microscopy-based assay with single-cell resolution enables screens...