A5102693348- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- RNA regulation and disease
- interferon and immune responses
- Gestational Diabetes Research and Management
- Folate and B Vitamins Research
- Pluripotent Stem Cells Research
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
Texas A&M University
2024
Texas A&M Health Science Center
2024
Prevention Institute
2024
Interactions between epigenetics and metabolites play critical roles in regulating the pluripotency differentiation of embryonic stem cells. Proper glucose metabolism DNA methylation are essential for orchestrating accurate lineage specification normal functions However, impact Ten-eleven Translocation (TET)-mediated modifications on mouse cells (mESCs) remains less well defined. In this study, we investigated consequences Tet triple knockout (Tet-TKO) mESCs observed notable alterations...
Abstract Background Myeloid cells play critical roles in the regulation of myocardial injury and repair. Clonal hematopoiesis (CH)‐related mutations genes, such as Ten‐eleven Translocation 2 (TET2), can impair myeloid are associated with increased risk cardiovascular disease (CVD). How Tet2 loss‐of‐function (LOF) impacts disrupts normal repair remains unclear. Methods We established ischemia‐induced infarction (MI) a myeloid‐specific Tet2‐deficient mouse model. The echocardiographic...