A5003869782- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Ion Transport and Channel Regulation
The Wistar Institute
2022
The extent to which effector CD8+ T cells infiltrate into tumors is one of the major predictors clinical outcome for patients with epithelial ovarian cancer (EOC). Immune cell infiltration EOC a complex process that could be affected by epigenetic makeup tumor. Here, we have demonstrated lysine 4 histone H3 (H3K4) demethylase, (lysine-specific demethylase 5A; KDM5A) impairs immune and inhibits antitumor responses. Mechanistically, found KDM5A silenced genes involved in antigen processing...
<div>Abstract<p>The extent to which effector CD8<sup>+</sup> T cells infiltrate into tumors is one of the major predictors clinical outcome for patients with epithelial ovarian cancer (EOC). Immune cell infiltration EOC a complex process that could be affected by epigenetic makeup tumor. Here, we have demonstrated lysine 4 histone H3 (H3K4) demethylase, (lysine-specific demethylase 5A; KDM5A) impairs immune and inhibits antitumor responses. Mechanistically, found...
Supplementary Figure from KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
Supplementary Figure from KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
<div>Abstract<p>The extent to which effector CD8<sup>+</sup> T cells infiltrate into tumors is one of the major predictors clinical outcome for patients with epithelial ovarian cancer (EOC). Immune cell infiltration EOC a complex process that could be affected by epigenetic makeup tumor. Here, we have demonstrated lysine 4 histone H3 (H3K4) demethylase, (lysine-specific demethylase 5A; KDM5A) impairs immune and inhibits antitumor responses. Mechanistically, found...