A5084069573- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Mathematical Biology Tumor Growth
- PARP inhibition in cancer therapy
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Nuclear reactor physics and engineering
- Cancer, Hypoxia, and Metabolism
- Health, Environment, Cognitive Aging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cell Image Analysis Techniques
- Chemistry and Stereochemistry Studies
- Radioactive Decay and Measurement Techniques
- Electron Spin Resonance Studies
- Bayesian Methods and Mixture Models
- Functional Brain Connectivity Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Machine Learning in Healthcare
- Science, Research, and Medicine
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Biomedical Text Mining and Ontologies
- Thyroid Cancer Diagnosis and Treatment
Instituto de Investigación Sanitaria de Santiago
2019-2023
Universidad de Los Andes
2016
In this work, we have investigated the sensitivity of effectiveness (TCP) molecular radiotherapy (MRT) treatment to uncertainties dose rate curves that may appear when reconstructing those curves. We generated different from experimental data, imposing constraint equal for each them. Then, computed TCPs and looked correlations between metrics measuring differences in TCP. Finally, according these results, estimated range tolerable The study was performed radiopharmaceuticals radiosensitive...
There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms cell death. Such effect seems to be two-fold. High may an immune response and cause vascular damage, leading starvation Development mathematical models, including death, help clinicians design SBRT optimal schedules. Despite experimental literature on tumor death caused by efforts modeling this have been limited. In work, we present a...
The purpose of this work is to calculate individualized dose distributions in patients undergoing
To investigate the possible contribution of indirect damage and saturation to tumour control obtained with SBRT/SRS treatments for early-stage NSCLC brain metastases.We have constructed a dataset metastases dose-response. These data were fitted models based on linear-quadratic (LQ), linear-quadratic-linear (LQL), phenomenological modifications LQ-model account cell damage. We use Akaike-Information-Criterion formalism compare performance, studied stability results changes in fitting...
Nowadays therapies involving radioiodine (I-131) represent 84% of the total metabolic treatments in Europe, according to last report European Association Nuclear Medicine relation treatment planning for molecular radiotherapy. Last recommendations Council, i.e. 2013/59/Euroatom, mandates that should be planned radiation doses delivered individual patients, analogous external beam In this work, we present a novel biokinetic model I-131 allows on obtain realistic activity distributions...
To obtain individualized internal doses with a Monte Carlo (MC) method in patients undergoing diagnostic [18F]FCH-PET studies and to compare such the MIRD calculations.
The linear-quadratic (LQ) model to describe the survival of irradiated cells may be most frequently used biomathematical in radiotherapy. There has been an intense debate on mechanistic origin LQ model. An interesting approach is that obtaining LQ-like behavior from kinetic models, systems differential equations induction and repair damage. Development such models particularly for application continuous dose rate therapies, as molecular radiotherapy or brachytherapy. In this work, we present...
Diodes dosimeters present a complex response to pulsed beams, with diode sensitivity varying dose-per-pulse, monitor unit rate (time between pulses) or number of integrated pulses. Such is caused by the kinetics interplay among charge carriers, recombination-generation centers, which capture excess minority carriers and facilitate recombination majority carrier, traps energy levels close conduction/valence band, can trap release carriers. This behavior has been well characterized...
We present a mechanistic biomathematical model of molecular radiotherapy thyroid disease. The general consists set differential equations describing the dynamics different populations cells with varying degrees damage caused by (undamaged cells, sub-lethally damaged doomed and dead cells), as well thyroglobulin antithyroglobulin autoantibodies, which are important surrogates treatment response. is presented in two flavours: on one hand, deterministic continuous model, useful to fit...
<div>Abstract<p>There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms cell death. Such effect seems to be two-fold. High may an immune response and cause vascular damage, leading starvation Development mathematical models, including death, help clinicians design SBRT optimal schedules. Despite experimental literature on tumor death caused by efforts modeling this have been limited....
<p>Extended presentation of the FEM solver, capillary model, pimo diffusion, and sensitivity analysis</p>
<p>Extended presentation of the FEM solver, capillary model, pimo diffusion, and sensitivity analysis</p>
<div>Abstract<p>There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms cell death. Such effect seems to be two-fold. High may an immune response and cause vascular damage, leading starvation Development mathematical models, including death, help clinicians design SBRT optimal schedules. Despite experimental literature on tumor death caused by efforts modeling this have been limited....