A5024899439- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Work-Related Fatigue
- Sleep and Wakefulness Research
- Sleep and related disorders
- Chemical synthesis and alkaloids
- Substance Abuse Treatment and Outcomes
- Biochemical Analysis and Sensing Techniques
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Smoking Behavior and Cessation
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Alcohol Consumption and Health Effects
- Olfactory and Sensory Function Studies
- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Older Adults Driving Studies
- Traffic and Road Safety
- Neuroscience of respiration and sleep
Maastricht University
2016-2025
The University of Sydney
2021
Inserm
2016
Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
2016
National Pension Service
2014-2015
University of Manchester
2013
Transnational University Limburg
1992-1993
To assess potential effects of lemborexant on next-morning driving performance in adult and elderly healthy volunteers.Randomized, double-blind, double-dummy, placebo active-controlled, four period incomplete crossover study 48 volunteers (22 females), 23-78 years old. Participants were treated at bedtime for eight consecutive nights with two three dose levels (2.5, 5, or 10 mg), zopiclone 7.5 mg (on the first last night intervening nights), placebo. Driving was assessed morning days 2 9...
Abstract There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions self-experience, depression. Accumulating preclinical evidence emphasizes role glutamate system acute action drug on brain and behavior; however this has never been tested humans. Following a double-blind, placebo-controlled, parallel group design, we utilized an ultra-high field multimodal imaging approach demonstrated that psilocybin (0.17...
Ayahuasca is a South American psychotropic plant tea traditionally used in Amazonian shamanism. The contains the psychedelic 5-HT2A receptor agonist N,N-dimethyltryptamine (DMT), plus β-carboline alkaloids with monoamine oxidase-inhibiting properties. Increasing evidence from anecdotal reports and open-label studies indicates that ayahuasca may have therapeutic effects treatment of substance use disorders depression. A recent study on psychological found reduces judgmental processing inner...
5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from parotoid glands of Bufo alvarius toad. Inhalation vapor toad containing 5-MeO-DMT has become popular naturalistic settings treatment mental health problems or means for spiritual exploration. However, knowledge effects humans limited.The first objective this study was assess sub-acute and long-term inhaling dried on affect cognition. The second whether any changes...
The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects THC. It possible then that containing equivalent CBD and THC will differentially affect cognition relative THC-dominant cannabis. present study investigated compared the THC/CBD on simulated cognitive In randomized, double-blind, within-subjects crossover design, healthy...
The objective of the current study was to assess separate and combined effects marijuana alcohol on actual driving performance. Eighteen subjects were treated with drugs placebo according a balanced, 6-way, crossover design. On evenings they given weight calibrated Delta(9)-tetrahydrocannabinol (THC) doses 0, 100 200 &mgr;g/kg without an dose sufficient for achieving blood concentrations (BAC) 0.04 g/dl while performing Road Tracking Car Following Test in normal traffic. Main outcome...
The current review summarizes the major results from all published studies 1983 to 2000 (9 double-blind, crossover, placebo-controlled in healthy volunteers and 1 baseline-controlled study patients) that have determined effects of antidepressants on actual driving performance using a standard test. That test measures impairment vehicular "weaving" (i.e., deviation lateral position [SDLP]) during hour on-the-road normal traffic.Changes SDLP after acute doses sedating amitriptyline,...
Previous research has shown that heavy cannabis users develop tolerance to the impairing effects of Δ9-tetrahydrocannabinol (THC) on neurocognitive functions. Animal studies suggest chronic consumption may also produce cross-tolerance for alcohol, but supportive data in humans is scarce. The present study was designed assess and THC alcohol users. Twenty-one participated a double-blind, placebo-controlled, three-way study. Subjects underwent three alcohol-dosing conditions were achieve...
<h3>Importance</h3> Cannabis use has been associated with increased crash risk, but the effect of cannabidiol (CBD) on driving is unclear. <h3>Objective</h3> To determine impairment caused by vaporized cannabis containing Δ<sup>9</sup>-tetrahydrocannabinol (THC) and CBD. <h3>Design, Setting, Participants</h3> A double-blind, within-participants, randomized clinical trial was conducted at Faculty Psychology Neuroscience Maastricht University in Netherlands between May 20, 2019, March 27,...
The present study investigated the nature of physiological cue reactivity and craving in response to alcohol cues among alcohol-dependent patients (N = 80) who were enrolled detoxification treatment. Further, predictive value with regard future drinking both magnitude while treatment degree alcohol-cue exposure patients' natural environment was assessed. Physiological experimental soft drink advertisements measured during using heart rate variability subjective rating craving. Following...
Δ9-Tetrahydrocannabinol (THC), the primary psychoactive constituent in cannabis, impairs psychomotor performance, cognition and driving ability; thus, under influence of cannabis is a public safety concern. We documented cannabis' psychomotor, neurocognitive, subjective physiological effects occasional frequent smokers to investigate potential differences between these smokers. Fourteen (≥4x/week) 11 (<2x/week) entered secure research unit ∼19 h prior smoking one 6.8% THC cigarette....
MDMA induces positive mood and increases impulse control during intoxication, but only a few studies on the neuropharmacological mechanisms underlying these processes have been conducted. It was hypothesized that pretreatment with 5-HT1 5-HT2 receptor blockers would prevent effects impulsivity. Subjects (N = 17) participated in double-blind, placebo controlled, within-subject design involving 6 experimental conditions consisting of (T1) treatment (T2). T1 preceded T2 by 30 minutes. T1–T2...