A5055631911- Genetics, Aging, and Longevity in Model Organisms
- Heat shock proteins research
- FOXO transcription factor regulation
- Telomeres, Telomerase, and Senescence
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Neurobiology and Insect Physiology Research
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Free Radicals and Antioxidants
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Invertebrate Immune Response Mechanisms
- Plant Genetic and Mutation Studies
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Curcumin's Biomedical Applications
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Science, Research, and Medicine
- Coronary Artery Anomalies
- Muscle Physiology and Disorders
- Medicinal Plants and Bioactive Compounds
Institute of Biology of Komi Scientific Centre
2017-2024
Ural Branch of the Russian Academy of Sciences
2023
Institute of Geology, Komi Science Centre
2023
Wockhardt (United States)
2023
Russian Academy of Sciences
2015-2019
Institute of Chemistry, Komi Science Center
2015-2018
Syktyvkar State University
2015-2017
Engelhardt Institute of Molecular Biology
2015
The molecular mechanisms that determine the organism's response to a variety of doses and modalities stress factors are not well understood. We studied effects ionizing radiation (144, 360 864 Gy), entomopathogenic fungus (10 100 CFU), starvation (16 h), cold shock (+4, 0 -4°C) on an viability indicators (survival locomotor activity) transcriptome changes in Drosophila melanogaster model. All but resulted decrease lifespan proportional dose treatment. However, stress-factors affected...
Abstract DNA repair declines with age and correlates longevity in many animal species. In this study, we investigated the effects of GAL4 -induced overexpression genes implicated on lifespan resistance to stress factors Drosophila melanogaster. Stress included hyperthermia, oxidative starvation. Overexpression was either constitutive or conditional ubiquitous tissue-specific (nervous system). Overexpressed those involved recognition damage (homologs HUS1, CHK2 ), nucleotide base excision...
The modulation of longevity genes and aging-associated signaling pathways using pharmacological agents is one the potential ways to prolong lifespan increase vitality an organism. Phytochemicals flavonoids non-steroidal anti-inflammatory drugs have a large as geroprotectors. goal present study was investigate effects long-term short-term consumption quercetin, (-)-epicatechin, ibuprofen on lifespan, resistance stress factors (paraquat, hyperthermia, γ-radiation, starvation), well...
Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective and neuroprotective properties. The present study intends to investigate the geroprotective action three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, Caenorhabditis elegans Drosophila melanogaster. Luteolin chrysin were shown improve lifespan parameters when administered both organisms. observed positive effects these D....
Transcriptional changes that contribute to the organism's longevity and prevent age-dependent decline of biological functions are not well understood. Here, we overexpressed pro-longevity gene encoding glutamate-cysteine ligase catalytic subunit (Gclc) analyzed in transcriptome associated with longevity, stress resistance, locomotor activity, circadian rhythmicity, fertility. Here reproduced life extension effect neuronal overexpression Gclc investigated its influence on age-depended...
Recent experimental studies highlighted the role of hydrogen sulfide (H2S) in aging and longevity. The cystathionine ß-synthase (CBS) γ-lyase (CSE) are key enzymes responsible for H2S production. Here we investigated geroprotective effects CSE CBS overexpression Drosophila. Overexpression did not affect a lifespan decrease (mitochondrial form CSE) or increase (cytoplasmic age dynamics locomotor activity, while median (by 12.5%) maximum 6.9%) activity. Increasing both expression levels...
We studied how aging affects the ability of Drosophila melanogaster to tolerate various types stress factors. Data were obtained on resistance D. oxidative and genotoxic (separately paraquat, Fe3+, Cu2+, Zn2+ ions), proteotoxic (hyperthermia, Cd2+ osmotic (NaCl) stresses, starvation, infection with pathological Beauveria bassiana fungus at different ages. In all cases, we observed a strong negative correlation between age tolerance. The largest change in age-dependent decline survival...
Some effects of aging in animals are tissue-specific. In D. melanogaster neuronal overexpression Gclc increases lifespan and improves certain physiological parameters associated with health benefits such as locomotor activity, circadian rhythmicity stress resistance. Our previous transcriptomic analyses Drosophila heads, that primarily composed tissue, revealed the significant changes expression levels genes involved aging-related signaling pathways (Jak-STAT, MAPK, FOXO, Notch, mTOR,...
Small RNAs are essential to coordinate many cellular processes, including the regulation of gene expression patterns, prevention genomic instability, and suppression mutagenic transposon activity. These processes determine aging, longevity, sensitivity cells an organism stress factors (particularly, ionizing radiation). The biogenesis activity small provided by proteins Argonaute family. participate in processing RNA precursors formation RNA-induced silencing complex. However, role...
Lifespan is a complex quantitative characteristic that makes significant contribution to the Darwinian adaptiveness. The disclosure of genetic structure longevity fundamental problem evolution ontogeny, evolutionary genetics and molecular gerontology. Under optimal conditions, lifespan determined by aging rate. process made up interrelated processes take place at organismal, tissue, cellular, levels. These include deregulation homeostasis maintenance, metabolic reactions sending intra-...
The JAK/STAT signaling pathway is involved in many aging-related cellular functions. However, effects of overexpression genes controlling signal transduction on longevity model organisms have not been studied. Here we evaluate the effect unpaired 1 (upd1) gene, which encodes an activating ligand for pathway, lifespan Drosophila melanogaster.Overexpression upd1 intestine caused a pronounced shortening median by 54.1-18.9%, and age 90% mortality 40.9-19.1% males females, respectively. In fat...