Background/Objectives: Cardiovascular complications are a leading cause of premature mortality in patients with acromegaly. Copeptin (CPP) correlates strongly plasma osmolality and is regulated by non-osmotic stimuli involved the pathophysiology cardiovascular disease. Mid-regional proadrenomedullin (MR-proADM), synthesized mainly adrenal medulla, vascular endothelial cells, heart, has vasodilatory effects. The study aimed to assess two biomarkers (CPP MR-proADM) acromegaly relation disease...

Psoriasis is often accompanied by obesity, hyperlipidemia, diabetes, and metabolic syndrome as risk factors of cardiovascular conditions premature mortality.The study was aimed at investigating whether psoriatic patients, who carry allele obesity-related FTO gene, are more predisposed to obesity disturbances it influences the severity psoriasis.197 patients with psoriasis, representing Lower Silesia region Poland, underwent physical examination anthropometric measurements. Blood samples for...

Irisin (Ir), a recently identified adipo-myokine, cleaved and secreted from the protein FNDC5 in response to physical activity, has been postulated induce differentiation of subset white adipocytes into brown fat mediate beneficial effects on metabolic homeostasis. Metabolic syndrome (MS), cluster factors leading impaired energy homeostasis, affects significant proportion subjects suffering polycystic ovary (PCOS). The aim our study was investigate relationship between Ir plasma...

The aim of this work was to evaluate whether the FokI and BsmI polymorphisms VDR gene are associated with anthropometric biochemical features cardiovascular disease (CVD) in a Caucasian population aged over 65, participants Polish PolSenior study. We performed study on randomly selected subjects: 427 women 454 men 65. Measurements parameters were carried out estimated using commercial kits. (rs10735810, rs1544410) genotyped by PCR FRLP. prevalence genotypes 50% Bb, 23% bb, 27% BB 48% 20% 32%...

Cardiovascular diseases are main cause of morbidity and mortality in acromegaly. Polymorphisms FTO gene associated with obesity increased risk CVD (independently BMI). Aim this study was to investigate the allele frequencies two polymorphisms: rs9939609 rs9930506 patients acromegaly examine association polymorphisms BMI selected metabolic parameters.Identification single nucleotide carried out 51 using minisequencing method.The risk-allele were 0.471 0.529, respectively they higher than...

Fat mass and obesity-associated gene (FTO) polymorphism remains the strongest known genetic determinant of common obesity. However, its influence depends on ethnicity, FTO-mediated predisposition to other metabolic disturbances is questionable.The aim our study was evaluate association between FTO rs9939609 syndrome in a population Prospective Urban Rural Epidemiology (PURE) Poland.We enrolled 1,097 participants PURE (683 women 414 men) from Lower Silesian voivodeship. Anthropometrical...

Polycystic ovary syndrome (PCOS) patients, frequently develop metabolic complications, such as insulin resistance (IR), impaired carbohydrate metabolism, dyslipidemia, obesity. Among the new markers responsible for disorders, preptin seems to be of great significance.One hundred and thirty-four women aged 17-45 were enrolled. PCOS was diagnosed in 73 on basis ESHRE-ASRM criteria. Non-PCOS group consisted 61 with regular menstruation matched nutritional status.All underwent anamnesis,...

Glypican-4 (Gpc4) is an adipokine which interacts with the insulin receptor and affects sensitivity in proteoglycans. Insulin resistance plays a crucial role etiology of polycystic ovary syndrome (PCOS). PCOS associated metabolic disturbances such as abdominal obesity, dyslipidemia type 2 diabetes. Thus, higher levels Gpc4 released from visceral adipose tissue women may suggest increased risk cardiovascular disease (CVD).The aim this pilot study was to determine whether serum level...

Background. The minor allele frequencies (MAFs) of the FTO gene vary substantially among different ethnic groups, and this variation may explain, to some degree, differences between estimates effects these alleles on body fat distribution indicators.Objectives. aim study was investigate prevalence mass obesity associated (FTO) variants characterizing structure haplotypes in a large Polish population, examine influence metabolically obese normal weight (MONW) individuals, i.e. those with BMI...

SARS-CoV2 infection can lead to severe cytokine storm especially in obese patients. Ghrelin acts not only as an appetite regulator but also play a key role the immune reaction. Leptin, secreted mainly by white adipose tissue, act pro-inflammatory cytokine. The crucial question is whether or COVID-19 patients with obesity linked adipokine dysregulation. aim of this study was assess ghrelin and leptin concentrations 6 months after comparison control group considering influence sex. included 53...

Introduction: Polycystic ovary syndrome (PCOS) is associated with an increasing number of metabolic comorbidities. About 50% PCOS patients are obese, and insulin resistance affects up to 70% these women. The endocannabinoid system contributes human energy homeostasis. CNR1 a biological candidate for obesity related disorders. aim this study was determine the relationships between polymorphisms anthropometric parameters in Material methods: 130 women diagnosed according Rotterdam criteria...

Introduction: The vitamin D receptor (VDR) gene is one of the most widely studied tumorigenesis-related genes. primary objective this study was assessment possible roles VDR polymorphisms in acromegaly with regard to activity disease and compared them a control group. Furthermore, we have assessed associations between these status as well TBS (trabecular bone score) risk for osteoporotic fracture patients. Materials methods: We 69 patients 51 healthy controls (CG). Acromegaly were divided...

The knowledge about obesity pathogenesis is insufficient. aim of our study was to investigate environmental and individual determinants in population PURE from Lower Silesia.This a cross sectional observation 1064 inhabitants Wroclaw neighbouring rural area (671 women, 393 men), who took part years 2007-2010. Each participant answered questionnaire International Physical Activity Questionnaire providing information risk factors. Anthropometric measurements were collected, blood samples taken...

Introduction The muscle is an endocrine organ controlling metabolic homeostasis. Irisin and myostatin are key myokines mediating this process. Acromegaly a chronic disease with wide spectrum of complications, including disturbances. Purpose To examine the influence acromegaly on irisin secretion their contribution to profile body composition. Materials Methods In 43 patients 60 controls, serum levels irisin, myostatin, growth hormone (GH), insulin-like factor 1 (IGF-1), parameters glucose,...

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)

Acromegaly is a rare endocrine disorder caused by somatotroph pituitary adenoma. Besides its typical symptoms, it contributes to the development of cardiovascular, metabolic, and bone comorbidities. H19 RNA long non-coding suspected be involved in tumorigenesis, cancer progression, metastasis. novel biomarker for diagnosis monitoring neoplasms. Moreover, there might an association between cardiovascular metabolic diseases. We enrolled 32 acromegaly patients 25 controls. investigated whether...

Introduction: We present the first longitudinal study in Poland analysing association between fat mass and obesity-associated gene (FTO) polymorphism changes anthropometric parameters. Material methods: 1120 participants of Prospective Urban Rural (PURE) (mean age 53.7 years) were genotyped for FTO (rs9939609, rs9930506, rs1421085, rs1121980). Anthropometric parameters measured at three time points (baseline, after years, six years observation). Results: The mean body index (BMI) group was...