A5049930474- Blood properties and coagulation
- Rheology and Fluid Dynamics Studies
- Fluid Dynamics and Turbulent Flows
- Particle Dynamics in Fluid Flows
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Lattice Boltzmann Simulation Studies
- Fluid Dynamics and Vibration Analysis
- Granular flow and fluidized beds
- Micro and Nano Robotics
- Aeolian processes and effects
- Cellular Mechanics and Interactions
- Lipid metabolism and disorders
- Cell Adhesion Molecules Research
- Wind and Air Flow Studies
- Protist diversity and phylogeny
- Microfluidic and Bio-sensing Technologies
- Blood groups and transfusion
- Cardiovascular Health and Disease Prevention
- Computer Graphics and Visualization Techniques
- Geotechnical and Geomechanical Engineering
- Acute Ischemic Stroke Management
- Microfluidic and Capillary Electrophoresis Applications
- Pickering emulsions and particle stabilization
- Fluid Dynamics and Thin Films
Rutgers, The State University of New Jersey
2015-2025
Office of the Governor
2022
Rutgers Sexual and Reproductive Health and Rights
2007-2020
University of Illinois Urbana-Champaign
2000-2004
University of Illinois System
2000
A direct numerical simulation (DNS) is used to study the effect of a freestream isotropic turbulent flow on drag and lift forces spherical particle. The particle diameter about 1.5–10 times Kolmogorov scale, Reynolds number 60–600, turbulence intensity 10%–25%. field considered here stationary, i.e., frozen in time. It shown that does not have substantial systematic time-averaged mean drag. standard correlation based instantaneous or relative velocity results reasonably accurate prediction...
The effect of free rotation on the drag and lift forces a solid sphere in unbounded linear shear flow is investigated. Reynolds number, Re=|ur|d/ν, range 0.5–200, where ur slip velocity. Direct numerical simulations three-dimensional past an isolated are performed using spectral methods. allowed to rotate translate freely response hydrodynamic torque acting it. studied systematic way by considering three sets simulations. In first set simulations, we study how fast pure rotational or...
We present computational fluid dynamic (CFD) simulation of aggregation two deformable cells in a shear flow. This work is motivated by an attempt to develop models red blood (RBCs). Aggregation RBCs major determinant viscosity microcirculation under physiological and pathological conditions. Deformability the plays role determining their aggregability. depends on cytoplasmic rigidity cell membrane, macroscopic sense. paper presents study RBC that takes into account rheology as well cell-cell...
Three-dimensional (3D) computational modeling and simulation are presented on the motion of a large number deformable cells in microchannels. The methodology is based an immersed boundary method, modeled as liquid-filled elastic capsules. model retains two important features blood flow microcirculation, that is, particulate nature deformation erythrocytes. tank-treading tumbling lateral migration, observed for erythrocytes dilute suspension, briefly discussed. We then present results...
Abstract Most previous numerical studies on capsule dynamics in shear flow have ignored the role of membrane viscosity. Here we present a method for large deformation capsules using Kelvin–Voigt viscoelastic model membrane. After introducing and related implementation, comprehensive analysis influence viscosity buckling, dynamics. We observe that leads to buckling range rate which no is observed with purely elastic For moderate rates, wrinkles surface appear same was reported earlier...
Partitioning of red blood cells (RBCs) at vascular bifurcations has been studied over many decades using in vivo, vitro, and theoretical models. These studies have shown that RBCs usually do not distribute to the daughter vessels with same proportion as flow. Such disproportionality occurs, whereby cell distribution fractions are either higher or lower than flow referred classical partitioning reverse partitioning, respectively. The current work presents a study RBC based on, for first time,...
Abstract Capillary blood vessels, the smallest vessels in body, form an intricate network with constantly bifurcating, merging and winding vessels. Red cells (RBCs) must navigate through such complex microvascular networks order to maintain tissue perfusion oxygenation. Normal, healthy RBCs are extremely deformable able easily flow narrow However, RBC deformability is reduced many pathological conditions during storage. The influence of cell on hemodynamics not well established. Here we use...
The interaction of an isolated spherical particle with isotropic turbulent flow is considered using direct numerical simulations (DNS). Reynolds number varied from about 50 to 600 and the diameter 1.5 10 times Kolmogorov scale. based on Taylor microscale free-stream field here 164. DNS technique employed first its kind address particle–turbulence it resolves smallest scales in complex vortical structures wake. primary objective this paper present new results effect turbulence wake vortex...
We present phase diagrams of the single red blood cell and biconcave capsule dynamics in dilute suspension using three-dimensional numerical simulations. The computational geometry replicates an vitro linear shear flow apparatus. Our model includes all essential properties membrane, namely, resistance against deformation, area dilatation, bending, as well viscosity difference between interior suspending fluids. By considering a wide range rate interior-to-exterior fluid ratio, it is shown...
Three-dimensional numerical simulations using a front-tracking method are presented on the dynamics of oblate shape capsules in linear shear flow by considering broad range viscosity contrast (ratio internal-to-external fluid viscosity), rate (or capillary number), and aspect ratio. We focus specifically coupling between deformation orientation capsules, show how this influences transition from tank-treading to tumbling motion. At low numbers, three distinct modes motion identified: swinging...
We present a 3D computational modeling study of the transport micro-scale drug carriers modeled as microparticles different shapes (spherical, oblate, and prolate) in whole blood represented suspension deformable red cells. The objective is to quantify effect microparticle on their margination, near-wall dynamics adhesion. observe that accumulation highest for oblate particles moderate aspect ratio, followed by spherical particles, lowest very elongated prolate particles. result explained...
Three-dimensional numerical simulation using the front-tracking method is presented on dynamics of a vesicle in linear shear flow. The focus here to elucidate parametric dependence and self-similarity dynamics, quantification deformation, analysis shape dynamics. A detailed comparison results made with various theoretical models experiments. It found that applicability limited despite some general agreement simulations deviations between perturbative occur even absence thermal noise....
An open question that has persisted for decades is whether the cytoskeleton of a red blood cell stress-free or under stress. This important in context theoretical modeling cellular motion flowing condition where it necessary to make an assumption about state. Here, we present 3D numerical study compare dynamics simple shear flow two different states, biconcave discocyte representing resting shape cell, and nearly spherical oblate shape. We find states significant difference not depends on...
Many numerical studies have considered the dynamics of capsules and red blood cells in shear flow under condition that axis revolution such bodies remained aligned plane. In contrast, several experimental shown could drift away from plane a certain range controlling parameters. this article, we present three-dimensional simulations on orientation simple with different initial undeformed shapes, namely, prolate, oblate, biconcave disk. It is observed unlike rigid ellipsoids Stokes flow,...
Abstract A computational study is presented on the flow of deformable red blood cells in stenosed microvessels. It observed that Fahraeus-Lindqvist effect significantly enhanced due to presence a stenosis. The apparent viscosity increase by several folds when compared non-stenosed vessels. An asymmetric distribution cells, caused geometric focusing vessels, play major role enhancement. asymmetry cell also results an average velocity and wall shear stress along length discrete motion causes...
Altered hemodynamics is a key factor for atherosclerosis. For decades, endothelial cell (EC) responses to fluid-generated wall shear stress have been the central focus atherogenesis. However, circulating blood not cell-free fluid, it contains mechanosensitive red cells (RBCs) that are also subjected altered and release large amount of ATP, but their impact on atherosclerosis has overlooked. The this study role (SS)-induced RBC-released ATP in Hypercholesterolemic mouse models with without...
Low-inertia pulsatile flows in highly distensible viscoelastic vessels exist many biological and engineering systems. However, existing works focus on inertial with small deformations. As such, here we study the dynamics of a tube at large deformation conveying low-Reynolds-number oscillatory flow using fully coupled fluid–structure interaction computational model. We detailed effect wall (solid) viscosity oscillation frequency deformation, rate, phase shift hysteresis, as well underlying...
Direct numerical solution for flow and heat transfer past a sphere in uniform is obtained using an accurate efficient Fourier-Chebyshev spectral collocation method Reynolds numbers up to 500. We investigate the temperature fields over range of numbers, showing steady axisymmetric when number less than 210, nonaxisymmetric without vortex shedding between 210 270, unsteady three-dimensional with above 270. Results from simulation are compared corresponding simulations Re>210 order see...
This study focuses on the effect of spatial non-uniformity in ambient flow forces acting a spherical particle at moderate Reynolds numbers. A scaling analysis is performed to obtain conditions under which such effects are important. direct numerical simulation, based spectral methods, used compute three-dimensional time-dependent past stationary sphere subject uniform plus planar straining flow. The number, Re , range 10 300 covering different regimes, from unseparated unsteady vortex...