A5103109746- Gastric Cancer Management and Outcomes
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Esophageal Cancer Research and Treatment
- Acute Myeloid Leukemia Research
- Mast cells and histamine
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Consumer Behavior in Brand Consumption and Identification
- HIV Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Sex work and related issues
- Colorectal Cancer Treatments and Studies
- Hematopoietic Stem Cell Transplantation
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Cultural Differences and Values
Loxo Oncology at Lilly (United States)
2024
Eli Lilly (United States)
2018-2024
McGill University
2018
Indiana University – Purdue University Indianapolis
2011-2016
Indiana University School of Medicine
2011-2015
Indiana University
2013
Japan Clinical Cancer Research Organization
2012
Royal Shrewsbury Hospital
2012
Joint United Nations Programme on HIV/AIDS
2003-2012
HIV Netherlands Australia Thailand Research Collaboration
2010
We aimed to identify factors associated with transmission of human immunodeficiency virus (HIV) from injecting drug users (IDUs) their wives in Manipur, northeast India, where the prevalence HIV among IDUs is 80% via a case-control study. One hundred and sixty-one HIV-infected were recruited September 1996 August 1997 inclusive. status was determined by enzyme-linked immunosorbent assay (ELISA) plus Western blot. Interviews administered anonymously. Regression analysis identified IDU...
Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients acute myeloid leukemia (AML) myeloproliferative neoplasms (MPNs), currently available drugs largely ineffective. Although Stat5 has been implicated regulating several lymphoid malignancies, how precisely regulates leukemogenesis, including its nuclear translocation to induce gene transcription, is poorly understood. In leukemic cells, we show constitutive activation focal adhesion kinase (FAK) whose...
Hyperactivation of the mTOR pathway impairs hematopoietic stem cell (HSC) functions and promotes leukemogenesis. mTORC1 mTORC2 differentially control normal leukemic functions. regulates p70 ribosomal protein S6 kinase 1 (S6K1) eukaryotic initiation factor 4E–binding (eIF4E-binding) (4E-BP1), modulates AKT activation. Given extensive crosstalk that occurs between signaling pathways, we assessed role substrate S6K1 in regulation both HSC leukemogenesis driven by mixed lineage leukemia (MLL)...
An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis patients systemic mastocytosis and acute myeloid leukemia (AML). Treatment of leukemic cells bearing this an allosteric inhibitor p21-activated (Pak) or its genetic inactivation results growth repression due to enhanced apoptosis. Inhibition upstream effector Rac abrogates oncogene-induced activity Pak. Although both Rac1 Rac2 are constitutively activated via guanine nucleotide...
For a sample of 170 undergraduate students, scores on Snyder's Self-monitoring scale were correlated .85 with Richins and Dawson's Materialism scale. This suggests that the constructs reflect similar externally focused cognitive orientation. In addition, stepwise regression indicated variance in is explained largely by success centrality components Materialism. Since these entail characteristic use external contextual cues, their predictive efficacy lends further support to an explanation...
Abstract Outreach interventions using ex‐IDUs to inform and educate their peers about HIV/AIDS prevention measures have been found be effective in the United States other developed countries. While programmes targeting IDUs also implemented a number of developing countries, very little information is available on process implementation these programmes. This paper attempts document some this knowledge by describing an outreach intervention small town—Churachandpur—with high injection drug...
Injecting drug users (IDUs) were recruited from the streets of Calcutta to obtain a baseline biological and behavioural data on risk practices. One-fifth them (mostly using buprenorphine) tested positive for hepatitis B surface antigen (HBsAg); 4% reactive serologic test syphilis (VDRL: Venereal Disease Research Laboratory). Condom use was insignificant while 74% reported sex with female workers 15% male IDUs also having men. Although, sharing injecting equipment ('works') perceived as...
To replicate and extend the 1986 work of Feinberg, effect a credit card's presence on subjects' spending behavior was assessed. Over-all, no main observed, which does not support Feinberg's conditioning hypothesis that cards function as spending-facilitating stimuli. These results held even for subjects who exhibited high scores materialism, assessed Belk's 1984 scale. Inasmuch our procedure replicated Feinberg's, contrasting might be attributed to either methodological differences (our...
The decision to treat advanced gastroesophageal cancers (GECs) with targeted therapy and immunotherapy is based on key biomarker expression (human epidermal growth factor receptor 2 (HER2), programmed cell death-ligand 1 (PD-L1), microsatellite instability (MSI), and/or mismatch repair (MMR)). Real-world data testing, results, treatment patterns are limited. This retrospective observational study used a nationwide electronic health record-derived de-identified database of patients from the...
Historically, high hepatocellular carcinoma (HCC)-related mortality has been, in part, due to lack of effective therapies; however, several systemic therapies have been recently approved for HCC treatment, including regorafenib and ramucirumab. These two treatments utilize different routes administration (four daily tablets biweekly intravenous infusions, respectively) risks adverse events (AEs). However, we data on patient preferences balancing the route risk AEs patients with HCC. We aimed...
Purpose: Liver metastasis (LM) is reported in approximately 40% of patients with advanced/ metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and associated a worse prognosis.This post-hoc analysis from the RAINBOW trial efficacy, safety, biomarker outcomes ramucirumab paclitaxel combination treatment (RAM+PAC) (LM+) without (LM-) LM at baseline.Materials Methods: Patients (n=665) were randomly assigned on 1:1 basis to receive either...