A5009599326- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Antibiotic Use and Resistance
- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Dermatological and Skeletal Disorders
- Global Cancer Incidence and Screening
- Diagnosis and Treatment of Venous Diseases
- Colorectal Cancer Screening and Detection
- Patient Satisfaction in Healthcare
- Pregnancy and Medication Impact
- Mast cells and histamine
- Skin Diseases and Diabetes
- Autoimmune Bullous Skin Diseases
- Pharmaceutical Practices and Patient Outcomes
- Body Image and Dysmorphia Studies
- Rheumatoid Arthritis Research and Therapies
- Complementary and Alternative Medicine Studies
- Telemedicine and Telehealth Implementation
- Autoimmune and Inflammatory Disorders Research
- Electronic Health Records Systems
- Primary Care and Health Outcomes
- Healthcare Systems and Technology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
University of Edinburgh
2015-2024
Edinburgh Cancer Research
2023
Western General Hospital
2016
Manchester Academic Health Science Centre
2011-2015
University of Manchester
2009-2015
Versus Arthritis
2014
Salford Royal NHS Foundation Trust
2011-2013
Alder Hey Children's NHS Foundation Trust
2011-2012
Mercy University Hospital
2012
NIHR Leeds Musculoskeletal Biomedical Research Unit
2012
Abstract Objective Childhood scleroderma encompasses a rare, poorly understood spectrum of conditions. Our aim was to ascertain the incidence childhood in its different forms UK and Ireland, describe age, sex, ethnicity cases. Methods The members 5 specialist medical associations including pediatricians, dermatologists, rheumatologists were asked report all cases abnormal skin thickening suspected be localized (including linear) or systemic sclerosis (SSc) children <16 years age first...
BackgroundUp to 60% of patients with Crohn's disease need intestinal resection within the first 10 years diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay clinical disease.MethodsWe did a randomised, placebo-controlled, double-blind trial at 29 UK secondary tertiary hospitals (aged >16 in Scotland >18 England Wales) who had confirmed diagnosis undergone resection. Patients were randomly assigned (1:1) by computer-generated...
Objectives. Nailfold videocapillaroscopy (NVC), the current gold standard for detection of capillary abnormalities suggestive an SSc-spectrum disorder, is not widely available: a key question whether lower-magnification, easy-to-use dermoscopy compares favourably. This especially relevant given inclusion capillaroscopic abnormality within 2013 classification criteria SSc. Our objectives were to examine ability classify capillaries and evaluate (severity), by both NVC dermoscopy, determine...
Objectives: Although digital ulcers (DUs) are common in patients with systemic sclerosis (SSc), prevalence estimates vary, and functional impact pathophysiology have been relatively little studied. We investigated the point of all DUs (both digital-tip extensor) a cohort SSc, testing hypothesis that both extensor associated impairment.Method: Over 12-month period, attending an SSc clinic for annual review were assessed by specialist nurses: active documented Hand Mobility Scleroderma (HAMIS)...
Objective. Randomized clinical trials in early diffuse cutaneous systemic sclerosis (dcSSc) are challenging. We used an observational approach to estimate the relative effectiveness of different current treatment approaches, capturing entry and outcome data a standardized way. Methods. Patients with dcSSc within 3 years onset skin thickening were included. Standardized followup collected relation first disease-modifying at baseline 4–6 weeks, then 3, 6, 12, 18, 24, 30, 36 months. The 5...
There has been a recent proliferation in treatment options for patients with metastatic breast cancer. Such treatments often involve trade-offs between overall survival and side effects. Our study aims to estimate the that could be used inform decision-making at individual policy level. We designed discrete choice experiment (DCE) look preferences avoiding severity levels of effects when choosing Treatment attributes were: fatigue, nausea, diarrhoea, other (peripheral neuropathy, hand-foot...
Objective. There have been few studies of quality life in childhood scleroderma and these focused predominantly on self-perception the influence skin lesions. Our cross-sectional study aimed to describe physical function relation clinical demographic measures. Methods. Children with either localized or systemic sclerosis (SSc) attending pediatric rheumatology clinics, together their parents guardians, were asked complete a set 4 validated Clinical data provided by consultant rheumatologists....
Background & AimsDNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA methylome patients requiring surgery predict Crohn's (CD) recurrence following intestinal resection; second compare seen with established CD that we had reported a series of inception cohorts.MethodsTOPPIC was placebo-controlled, randomized...
Our aim was to describe clinical features and pattern of care in children with localized scleroderma presenting secondary during a 25-month incidence study.Eighty-seven patients were identified, features, serum autoantibodies, current treatment outcome at 12 months documented.Fifty-eight (67%) had linear scleroderma, 25 (29%) non-linear morphoea 4 (4%) mixed pattern. Of the 58 29 (50%) presented lesions trunk and/or limbs only, 26 (45%) face-head localization only 3 (5%) both. Thirteen (15%)...
Telangiectases represent microvascular changes inherent in the systemic sclerosis (SSc) disease process. Intense pulsed light (IPL) is an effective treatment for non-SSc-related cutaneous telangiectases.This pilot study aimed to examine efficacy, safety and tolerability of IPL open patients with SSc.Patients underwent three treatments at monthly intervals attended follow-up examinations 1, 6 12 months after final treatment. Photographs, laser Doppler imaging (LDI) thermography were used...
Objectives Leri’s pleonosteosis (LP) is an autosomal dominant rheumatic condition characterised by flexion contractures of the interphalangeal joints, limited motion multiple and short broad metacarpals, metatarsals phalanges. Scleroderma-like skin thickening can be seen in some individuals with LP. We undertook a study to characterise phenotype LP identify its genetic basis. Methods results Whole-genome single-nucleotide polymorphism genotyping two families defined microduplications...
Background Antimicrobial resistance, the ability of microorganisms to survive antimicrobial drugs, is a public health emergency. Although electronic prescribing (ePrescribing)–based interventions designed reduce unnecessary usage exist, these often do not integrate effectively with existing workflows. As result, ePrescribing-based may have limited impact in addressing resistance. Objective We sought understand stewardship (AMS) practices an English hospital preceding implementation...
BackgroundColorectal cancer (CRC) is the fourth most common type of in United Kingdom and second leading cause death. Despite improvements CRC survival over time, Scotland lags behind its UK European counterparts. In this study, we carry out an exploratory analysis which aims to provide contemporary, population level evidence on treatment Scotland. MethodsWe conducted a retrospective population-based adults with incident registered Scottish Cancer Registry (Scottish Morbidity Record 06...
IntroductionCurrent understanding of cancer patients, their treatment pathways and outcomes relies mainly on information from clinical trials prospective research studies representing a selected sub-set the patient population. Whole-population analysis is necessary if we are to assess true impact new interventions or policy in real-world setting. Accurate measurement geographic variation healthcare use also population-level data. Routine access such data offers efficiency resource allocation...
Abstract Background Antimicrobial resistance is a leading global public health threat, with inappropriate use of antimicrobials in healthcare contributing to its development. Given this urgent need, we developed complex ePrescribing-based Anti-Microbial Stewardship intervention (ePAMS+). Methods ePAMS+ includes educational and organisational behavioural elements, plus guideline-based clinical decision support aid optimal antimicrobial hospital inpatients. particularly focuses on prompt...
Objectives. DNA methylation is one of the best-characterized epigenetic modifications that have been implicated in numerous biological and pathological processes. It initiated by methyltransferases (DNMTs) 3a 3b maintained maintenance enzyme DNMT1. now believed to be a dynamic process as active demethylation has observed. Thus, during cellular division competition between DNMT1 demethylase determine or reversal daughter cells. The molecular identity remains elusive but its activity can...
Background Crohn’s disease (CD) is a chronic, relapsing, inflammatory bowel disease. Up to 65% of patients with CD require an operation control the within 10 years. Both endoscopic and clinical recurrence common 2 years operation, re-operation rates cumulating at 5% per year. Objectives This study assessed if use mercaptopurine (MP) can prevent or delay postoperative in CD. Design An individually randomised, multicentre, double-blind, placebo-controlled trial follow-up 6, 13, 31, 49, 67, 85,...