A5006327824- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Paranormal Experiences and Beliefs
- Vaccine Coverage and Hesitancy
- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Yersinia bacterium, plague, ectoparasites research
- Nutrition, Genetics, and Disease
- Healthcare Policy and Management
- Epigenetics and DNA Methylation
- Food Security and Health in Diverse Populations
- COVID-19 epidemiological studies
- Global Health Care Issues
- Psychosocial Factors Impacting Youth
- Urban and Rural Development Challenges
- Immune responses and vaccinations
- Child Nutrition and Water Access
- Urban Agriculture and Sustainability
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- COVID-19 Clinical Research Studies
- Nutrition, Health and Food Behavior
- Healthcare Education and Workforce Issues
- Motivation and Self-Concept in Sports
- Biological Research and Disease Studies
University of Pennsylvania
2020-2024
Institute of Group Analysis
2024
Analysis Group (United States)
2023-2024
Grand Valley State University
2022
American University
2022
National Bureau of Economic Research
2019-2022
Eastern Michigan University
2022
Penn Center for AIDS Research
2022
Genomics (United Kingdom)
2022
Lehigh University
2019
Abstract INTRODUCTION Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Disease (ACAD) was formed to address underrepresentation of Asians research, and limited understanding how genetics non‐genetic/lifestyle factors impact this multi‐ethnic population. METHODS ACAD started fully recruiting October 2021 with one central coordination site, eight recruitment sites, two analysis sites. We developed comprehensive...
Abstract While awaiting the COVID-19 vaccines, researchers have been actively exploring effectiveness of existing vaccines against new virus, among which BCG vaccine (Bacillus Calmette-Guérin) receives most attention. many reports suggest a potential role for immunization in ameliorating SARS-CoV-2 infection, these findings remain controversial. With country-level outbreak data from Johns Hopkins University Coronavirus Resource Center, and program World Atlas Policies Practices WHO/UNICE, we...
Recent Alzheimer's disease (AD) genetics findings from genome-wide association studies (GWAS) span progressively larger and more diverse populations outcomes. Currently, there is no up-to-date resource providing harmonized searchable information on all AD genetic associations found by GWAS, nor linking the reported variants genes with functional genomic annotations.
To better capture the polygenic architecture of Alzheimer's disease (AD), we developed a joint genetic score, MetaGRS. We incorporated variants for AD and 24 other traits from two independent cohorts, NACC (n = 3,174, training set) UPitt 2,053, validation set). One standard deviation increase in MetaGRS is associated with about 57% risk [hazard ratio (HR) 1.577, p 7.17 E-56], showing little difference HR GRS alone (HR 1.579, 1.20E-56), suggesting similar utility both models. also conducted...
Abstract This paper evaluates the effect of COVID-19 vaccination on individual propensity to delay or skip medical care. Our research design exploits arguably exogenous variation in age-specific vaccine eligibility rollout across states and over time as an instrument for status. We find that receiving a reduces likelihood delaying care any condition by 37%. Furthermore, our analysis reveals children are significantly less likely healthcare result their parents becoming eligible, indicating...
To compare all-cause and Alzheimer's disease (AD)-related healthcare resource utilization (HCRU) by cognitive stage.
Abstract Alzheimer’s Disease (AD) genetics has made substantial progress through genome-wide association studies (GWASs). An up-to-date resource providing harmonized, searchable information on AD genetic variants with linking to genes and supporting functional evidence is needed. We developed the Variant Portal (ADVP), an extensive collection of associations curated from >200 GWAS publications Genetics Consortium (ADGC) other researchers. Publications are reviewed systematically extract...
Superstition is a widespread phenomenon. We empirically examine its impact on health-related behavior and health outcomes. study the case of Taiwanese Ghost month. During this period, which believed to increase likelihood bad outcomes, we observe substantial adaptions in behavior. Our identification exploits idiosyncratic variation timing Month across Gregorian calendar years. Using high-quality administrative data, document for period Months reductions mortality, hospital admissions,...
We study the effect of access to tap water in early childhood on children’s university admission using data from Taiwan years 1978–80. Because is managed by a operation station household’s county, our identification strategy relies two geographic attributes: (i) instrumental variable distance house nearest station, and (ii) sample children born families that live border county. find significantly increases probability admission.
Abstract Background Previous studies have indicated that prediction performance of a genetic risk score is improved when the built using information about multiple traits/risk factors associated with target trait. To better capture polygenic architecture Alzheimer’s Disease, we developed joint score, MetaGRS. Method We incorporated variants for AD and 24 other traits from two independent cohorts, NACC (n = 3,174, training set) UPitt 2,053, validation set). Result One standard deviation...
Predictive information exists ubiquitously in the visual environment. Such signals probability or likelihood of upcoming events, thus facilitating system preparing optimal responses advance. This ability to implicitly acquire predictive and probabilistic has been well documented by behavioral evidence from many domains (e.g., spatial, temporal, abstract probability). Recently, neurophysiological studies have begun elucidate neural mechanisms underlying these learning processes suggest a...
Abstract Background Alzheimer’s disease (AD) genetic findings span progressively large genome‐wide association studies (GWASs) and meta‐analyses, with no single resource providing unified, searchable information on identified variants genes supporting functional genomic evidence. We developed ADVP (Alzheimer’s Disease Variant Portal), a curated harmonized interactive platform that provides unified access visualization of uniquely extensive up‐to‐date collection GWAS data for AD. Methods The...
The Alzheimer's Disease Variant Portal (ADVP, https://advp.niagads.org) is a curated and harmonized interactive platform providing the research community with unified way to access visualize largest up-to-date collection of disease (AD) genetic findings from >200 genome-wide association studies (GWASs). In this study, we aim characterize regulatory roles mechanisms underlying these signals in AD.We analyzed all Caucasian significant ADVP (348 variants 186 loci) using FILER (Kuksa et al.,...