While vinyl cyclopropanes are valuable functional groups in drugs or natural products as well established precursors to trigger a rich variety of synthetic transformations, their reactive nature can make installation via direct catalytic approaches challenging. We herein present modular access (di)vinyl under very mild conditions and full conservation stereochemistry, allowing the cis trans cyclopropane- E Z vinyl-stereochemical relationships. Our protocol relies on air-stable dinuclear Pd

A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use furan substituent allows high trans diastereoselectivity be achieved during and it contains four carbon atoms C1-C4 natural product oxidation state closely related one target molecule. eight-step requires six purifications provides...

A radiochemical procedure for the determination of plutonium (Pu) and uranium (U) radionuclides in ice samples by multicollector inductively coupled plasma mass spectrometer (MC-ICP-MS) is presented. Pu U are preconcentrated coprecipitation then separated extraction chromatography. The purified fractions analyzed MC-ICP-MS. Detection limits 2 × 10 –3 3 10–6 mBq kg–1 were achieved 239Pu 236U, respectively. Surface collected from Gauli glacier (Switzerland) this method. surface Glacier retains...

Abstract The stereoselectivity and stereospecificity of the triflate‐mediated intramolecular Schmidt reaction substituted 3‐(1‐azidocyclohexyl)propanol derivatives leading to octahydro‐1H‐pyrrolo[1,2‐a]azepine, structural skeleton several important families alkaloids such as Stemona alkaloids, has been examined. involves an initial S N 2 between azide moiety triflate affording intermediate spirocyclic aminodiazonoium salt that undergoes expected 1,2‐shift/N ‐elimination followed by...

Abstract. In the 1950s and 1960s, specific radionuclides were released into atmosphere as a result of nuclear weapons testing. This radioactive fallout left its signature on accumulated layers glaciers worldwide, thus providing tracer for ice particles traveling within gravitational flow being ablation zone. For surface dating purposes, we analyze here activity 239Pu, 240Pu 236U derived from more than 200 samples collected along five flowlines at Gauligletscher, Switzerland. It was found...

Molecular docking has traditionally mostly been employed in the field of protein-ligand binding. Here, we extend this method, combination with DFT-level geometry optimizations, to locate guest molecules inside pores metal-organic frameworks. The position and nature tune physicochemical properties host-guest systems. Therefore, it is essential be able reliably them rationally enhance performance known frameworks facilitate new material discovery. results obtained approach are compared...

Molecular docking has traditionally mostly been employed in the field of protein- ligand binding. Here, we extend this method, combination with DFT-level geometry optimizations, to locate guest molecules inside pores metal-organic frameworks. The position and nature tune physicochemical properties host-guest systems. Therefore, it is essential be able reliably them rationally enhance performance known frameworks facilitate new material discovery. results obtained approach are compared...

Abstract. In the 1950s and '60s, specific radionuclides were released into atmosphere as a result of nuclear weapons testing. This radioactive fallout left its signature on accumulated layers glaciers worldwide, thus providing tracer for ice particles traveling within gravitational flow being ablation zone. For surface dating purposes, we analyze here activity 239Pu, 240Pu 236U derived from more than 200 samples collected along five flowlines at Gauligletscher, Switzerland. It was found that...

Abstract The stereoselectivity and stereospecificity of the triflate‐mediated intramolecular Schmidt reaction substituted 3‐(1‐azidocyclohexyl)propanol derivatives leading to octahydro‐1H‐pyrrolo[1,2‐a]azepine, structural skeleton several important families alkaloids such as Stemona alkaloids, has been examined. involves an initial S N 2 between azide moiety triflate affording intermediate spirocyclic aminodiazonoium salt that undergoes expected 1,2‐shift/N ‐elimination followed by...

Molecular docking has traditionally mostly been employed in the field of protein-ligand binding. Here, we extend this method, combination with DFT-level geometry optimizations, to locate guest molecules inside pores metal-organic frameworks. The position and nature tune physicochemical properties host-guest systems. Therefore, it is essential be able reliably them rationally enhance performance known frameworks facilitate new material discovery. results obtained novel method are compared...

Abstract While vinyl cyclopropanes are valuable functional groups in drugs or natural products as well established precursors to trigger a rich variety of synthetic transformations, their reactive nature can make installation via direct catalytic approaches challenging. We herein present modular access (di)vinyl under very mild conditions and full conservation stereochemistry, allowing the cis trans cyclopropane‐ E Z vinyl‐stereochemical relationships. Our protocol relies on air‐stable...

A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use furan substituent allows achieve high trans diastereoselectivity during and it contains four carbon atoms C1–C4 natural product oxidation state closely related one target molecule. eight-step require six purifications provides 18%...

<div><div><div><div><p>A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use furan substituent allows achieve high trans diastereoselectivity during and it contains four carbon atoms C1–C4 natural product oxidation state closely related one target...

The stereoselectivity and stereospecificity of the triflate mediated intramolecular Schmidt reaction substituted 3-(1-azidocyclohexyl)propanol derivatives leading to octahydro-1<i>H</i>-pyrrolo[1,2-a]azepine, structural skeleton several important families alkaloids such as <i>Stemona</i> alkaloids, has been examined. involves an initial S<sub>N</sub>2 between azide moiety affording intermediate spirocyclic aminodiazonoium salt that undergoes expected...

The stereoselectivity and stereospecificity of the triflate mediated intramolecular Schmidt reaction substituted 3-(1-azidocyclohexyl)propanol derivatives leading to octahydro-1 H -pyrrolo[1,2-a]azepine, structural skeleton several important families alkaloids such as Stemona alkaloids, has been examined. involves an initial S N 2 between azide moiety affording intermediate spirocyclic aminodiazonoium salt that undergoes expected 1,2-shift/N -elimination followed by hydride iminium...

The stereoselectivity of the triflate mediated intramolecular Schmidt reaction substituted 3-(1-azidocyclohexyl)propanol derivatives leading to octahydro-1 H -pyrrolo[1,2-a]azepine, structural skeleton several important families alkaloids such as Stemona alkaloids, has been examined. involves an initial S N 2 between azide moiety and affording intermediate spirocyclic aminodiazonoium salt that undergoes expected 1,2-shift/N -elimination followed by hydride iminium reduction. Remarkably,...