A5073455957- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Essential Oils and Antimicrobial Activity
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
- Nanoparticle-Based Drug Delivery
- Proteoglycans and glycosaminoglycans research
- RNA Interference and Gene Delivery
- Bee Products Chemical Analysis
- Graphene and Nanomaterials Applications
- Surfactants and Colloidal Systems
- Autoimmune and Inflammatory Disorders Research
- Dermatology and Skin Diseases
- Genetic Associations and Epidemiology
- Skin Protection and Aging
- Psoriasis: Treatment and Pathogenesis
- Cardiac, Anesthesia and Surgical Outcomes
- Drug Solubulity and Delivery Systems
- Hydrogels: synthesis, properties, applications
- Systemic Lupus Erythematosus Research
- Advanced Polymer Synthesis and Characterization
- Ocular Surface and Contact Lens
- Surgical site infection prevention
- Sphingolipid Metabolism and Signaling
Quaid-i-Azam University
2018-2025
Methotrexate (MTX) is the first line agent for therapy against rheumatoid arthritis (RA); however, orally its efficacy hampered by poor solubility, less permeability, short plasma half-life, and reduced bioavailability. Meanwhile, parenteral formulations are associated with severe adverse effects. In an attempt to improve of MTX, we synthesized polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) triblock copolymer a ring-opening copolymerization reaction used it as carrier...
Methotrexate (MTX), the gold standard against psoriasis, poses severe problems when administered systemically viz increased toxicity, poor solubility and adverse reactions. Hence, a topical formulation of MTX for management psoriasis can be an effective approach. The present study aimed to develop based nanoparticle-loaded chitosan hydrogel evaluating its potential efficacy in imiquimod-induced psoriatic mice model. MTX-NPs loaded was prepared optimized using o/w emulsion solvent evaporation...
Transdermal hydrogels have the potential to improve therapeutic outcomes via enhancing bioavailability and reducing toxicity associated with oral delivery. The goal of present study was formulate optimise argan oil loaded transdermal hydrogel containing lipid nanoparticles. high pressure homogenization (HPH) method utilised fabricate Simvastatin solid nanoparticles (SIM-SLNs) precirol ATO 5 as a core Poloxamer 407 (P407) stabilise core. optimised nanoformulation characterised for its...
Methicillin resistant Staphylococcus aureus (MRSA) induced skin infections have become a challenging problem due to the escalating antibiotic resistance. Carvacrol (CAR) has been reported be effective against MRSA. However, its characteristics, CAR exhibits low retention. In this study, was formulated into site-specific nanoparticle (NPs) delivery system using poly(ε-caprolactone) (PCL), following incorporation hydrogel matrix facilitate dermal delivery. The release study exhibited...
Aim: To formulate and evaluate a pH-responsive nanoparticle (NP)-based patch for efficient transdermal delivery of flurbiprofen against rheumatoid arthritis. Materials & methods: Nanoprecipitation technique was used preparation NPs central composite design employed optimization purposes. Optimized were loaded into the by solvent evaporation method. Results: Prepared exhibited an average size 69 nm, while onto showed sustained release high permeation through skin. In in vivo studies, prepared...
This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition highlighting clarifying common ambiguities the literature this regard. Proposing a model study, shows how most of professed energetically systems are actually unstable, subjected indiscriminate false characterization, leading significant effects for their pharmaceutical applications. A drug delivery system (SEDDS) developed then...
Burns are highly traumatizing injuries that can be complicated by various microbial infections, leading to morbidity and mortality. The ultimate goal of burn therapy is prevent any infection rapid wound healing with epithelization. current study aimed develop investigate the potential nanoemulsion-based cosmetotherapeutic lotion silver sulfadiazine (SSD) for increased antimicrobial activity treat injuries. Silver standard topical treatment patients, but allied major limitations poor...
This study aimed to develop and optimise a Curcumin-loaded SLNs (C-SLNs) patch through new approach for transdermal delivery. C-SLNs were optimised the response surface central composite design using modified injection method. Optimised loaded into polyvinyl alcohol-based backing membrane Compatibility studies (FTIR, XRPD), in vitro release, ex vivo skin permeation, accelerated stability, evaluation of also performed. Prepared exhibited average particle diameter 170 ± 2 nm with an...
The spread of drug-resistant tuberculosis (DR TB) poses significant challenges to the control and successful eradication TB globally. current retrospective study was designed evaluate treatment outcomes identify risk factors associated with unsuccessful among DR patients. A total 277/308 eligible patients were enrolled for at programmatic management unit Pakistan Institute Medical Sciences, Islamabad between January 2014 July 2019. Treatment defined according WHO recommendations. Death,...
Retinoids are considered the mainstay treatment for moderate to severe acne. Adapalene, a third-generation retinoid, has physiochemical properties which hinder effective delivery of drug skin. Therefore, current study aimed develop and evaluate adapalene liposomal loaded gel (ADA-LP gel) management acne improve tolerability targeted sites as compared conventional dosage form drug. A novel spontaneous phase transition method (SPT) was used formulate liposomes. Liposomal formulation (ADA-LP)...
Biodegradable polymers are extensively used due to their efficient safety profiles. The aim of the current study was fabricate, evaluate, and characterize biodegradable, biocompatible fluconazole (FLZ) loaded chitosan (CHS) chondroitin sulfate (CS) nanoparticles (NPs) for topical delivery. Polymers utilized in formulation not only served as a carrier system but also aided fighting with complex etiology disease innate antifungal activities.NPs were prepared by coacervation method, then...