Objective. To study several non-respiratory lung functions in conjunction with the respiratory component acute abdominal diseases different natures of inflammatory process; to identify key mechanisms organ damage; and, based on data, establish a new syndrome urgent surgery—pulmonary distress syndrome—and evaluate effectiveness Remaxol its treatment. Material and methods. Chronic experiments have been done dogs. Under anesthesia, progressive peritonitis was simulated first group (24) (the...

Introduction. The hemostatic system plays an important role in exacerbating the pathogenic processes of acute pancreatitis and development complications, but it is still insufficiently studied. aim study to explore relationship between oxidative stress coagulation patients with pancreatitis. Materials methods. Fifty were studied divided into two groups: first group (n = 24) had a mild form disease, second 26) severe form. To determine disorders stress, assessment endotoxicosis, lipid...

Introduction. The polymorbidity characteristic of geriatric patients exerts a complex impact on the regulatory mechanisms cardiac function, significantly increasing likelihood arrhythmias and conduction disturbances when compared to younger age groups. aim this study is examine frequency disorders in with comorbid cardiovascular pathology order identify gender-specific features. Materials methods. A retrospective analysis was conducted 50 medical histories from cardiology department...

To justify the concept of systemic membrane-destabilizing distress syndrome in surgery via analysis phospholipid bilayer cell membranes various organs urgent surgical abdominal diseases.Experimental research on dogs (n=90) included modeling peritonitis, pancreatitis, intestinal obstruction, obstructive jaundice, and post-hemorrhagic anemia. Clinical laboratory studies were performed patients (n=119) with acute severe anemia, cholecystitis, gastrointestinal bleeding, benign mechanical...

The purpose of the study is to determine correlation changes in humoral and tissue components hemostasis system with lipid metabolism case various urgent surgical diseases, on basis which systemic coagulopathic distress syndrome can be used as scientific for definition a new syndrome.The work includes results experimental clinical laboratory tests. Experiments dogs: first group (n=18) destructive pancreatitis; second - fecal peritonitis; third (n=15), acute obstructive intestinal...

Цель. Оценка роли модификаций липидов тканей печени в ее детоксикационной способности при остром перитоните. Методика. В эксперименте у собак моделировали острый перитонит различной степени тяжести. Степень эндогенной интоксикации оценивали по уровню токсических продуктов гидрофильной и гидрофобной природы. Представлен новый способ оценки функции на основе определения уровня крови, притекающей к органу оттекающей от него. Для характеристики качественного количественного состава из...

Acute pancreatitis remains one of the most dangerous pathologies in structure emergency abdominal surgery. This is due to many reasons, including an increase frequency destructive forms disease, high mortality, and frequent unfavorable outcomes. The aim this study was investigate a number leading components homeostasis patients with acute varying severity. A retrospective conducted on 50 diff erent severity levels who were hospitalized at Republican Clinical Hospital named after S.V. Katkovа...

Background. Mechanical jaundice (MF) and cholangitis are considered to be of great significance in emergency surgery due their complex pathogenesis, risk complications high mortality. Objective. To establish the severity hemostatic disorders association with fibrinogen gene polymorphism (FGB (G(-455)A)) patients non-cancerous MF varying severity. Material methods. The subjects were 25 benign divided into 2 groups: group 1 (n=12) – those a mild form disease; (n=13) severe form. research...

Despite significant progress in the study of acute pancreatitis (AP), components its patho-logical mechanism are still active search. Moreover, risk progression and complications increases presence metabolic syndrome, especially diabetes mellitus (DM). In patients with mellitus, to establish features microcirculation disorders association polymorphism C774T eNOS gene. 56 pancreatitis. Depending on divided into 2 groups: first – without DM; second DM. The research methods included...

AIM OF THE STUDY. To establish the incidence of acute thrombosis veins lower extremities and activity most significant trigger agents that led to this complication in patients with a new coronavirus infection. MATERIAL AND METHODS. The clinical section work is presented by observations 123 surgical pathology extremities. first group (comparison) (n = 48) included extremities, second (studied) 87) similar problem arose against background All underwent interventions: thrombectomy plication....

Introduction . Cardiorenal disorders (CRN) in arterial hypertension (AH) occur with interdependent dysfunction of the cardiovascular and renal systems. The concept cardio-reno-metabolic health (CRMH) defines a dependent relationship between clinical pathogenetic manifestations heart kidney diseases patients metabolic (MN). Aim To study markers CRN combination syndrome (MS). Materials methods functions heart, kidneys, lipid profile were studied aged 40 to 69 years MS. Results average eGFR...

To study the features of development endogenous intoxication in association with damage to organs detoxification system, severity catabolic processes associated activity peroxidation membrane lipids and phospholipases various urgent pathology abdomen, on basis which develop a new pathogenetically based approach prevention progression surgical endotoxicosis.Clinical section. The studies were conducted 162 patients acute (seven groups) predominant aseptic inflammation (acute severe...

In recent years, the study of functional state lungs has become a topical issue for urgent surgery. This is due to fact that play an important role in regulation inflammatory response, and body balance control. The aim establish detoxification hemostasis-correcting lung ability acute pancreatitis experimentally clinically; determine effectiveness quantum metabolic therapy correcting status. Materials Methods. experiments were performed on adult dogs (n=30). animals divided into two groups:...

The urgency of the problem acute peritonitis in surgical practice is due to annual increase morbidity, a high number complications, therapeutic complexity and mortality. Materials methods. material study was 45 patients with peritonitis, who were divided into 3 groups depending on course pathology after surgery. first group (n=15) – without second wound third tertiary sepsis. In addition standard research methods, laboratory tests are included determine severity intoxication, oxidative...

Goal. To identify key links in the pathogenesis of toxic myocardiopathy conditions endogenous intoxication peritonitis. Materials and methods. Experimental studies were carried out on dogs ( n = 24). The model purulent fecal We studied run-time content products blood plasma, lipid composition, intensity peroxidation, activity phospholipase A2 superoxide dismutase, hypoxia myocardial tissue. evaluated loss water proteins, electrogenesis myocardium cells changes ECG parameters. also performed...

The problem of diagnostics and treatment acute pancreatitis (AP) is relevant for emergency surgery. Both clinicians specialists in paraclinical disciplines thoroughly examine pathogenesis this serious disease, as their observations will contribute greatly to targeted therapy. hemostatic disorders still remains one the poorly studied. aim work assess system patients with various severity upon admission clinic. Materials Methods. authors examined 48 pancreatitis, who were divided into two...

В хронических экспериментах на собаках с прогрессирующим каловым перитонитом изучали влияние ремаксола развитие эндогенной интоксикации и детоксикационную способность печени. Показано, что ремаксол сохраняет резистентность печени к действию продуктов перекисного окисления липидов активизации фосфолипаз. Высказано предположение о возможности включения в перечень лекарственных препаратов, применяемых при остром перитоните целью поддержания функционального состояния

The OBJECTIVE was to give a molecular genetic foundation of combination therapy in the early postoperative period for peritonitis. METHODS AND MATERIALS . 70 patients with diffuse peritonitis were studied: first (n=35) – underwent basic treatment, second combined treatment inclusion Remaxol and laser irradiation. severity endotoxemia oxidative stress, state hemostasis system functional status liver determined. Molecular genotyping following genes performed: beta subunits platelet fibrinogen...

In order to determine the effectiveness of use remaxol based on a personalized approach in patients with acute pancreatitis, establishment gene polymorphism integrin beta-3 (T1565C, ITGB3), alpha-2 (C807T, ITGA2), fibrinogen (G(-455)A, FGB) and plasminogen activator inhibitor (5G(-675)4G, SERPINE1), study 84 pancreatitis varying severity was conducted. As result study, it proved that increase treatment severe upon admission, addition clinical, laboratory instrumental studies, is necessary...