A5052177614- Pharmacogenetics and Drug Metabolism
- Biosensors and Analytical Detection
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lanthanide and Transition Metal Complexes
- Chemotherapy-induced organ toxicity mitigation
- Metal complexes synthesis and properties
- Coccidia and coccidiosis research
- Ferrocene Chemistry and Applications
- Analytical Methods in Pharmaceuticals
- Water Treatment and Disinfection
- Polyamine Metabolism and Applications
Istanbul University
2020-2025
International Drug Development
2025
Czech Academy of Sciences, Institute of Analytical Chemistry
2025
In 2018, the Food and Drug Administration European Medicines Agency identified nitrosamine impurities in certain drugs, prompting detailed investigations by international regulatory authorities. According to ICH M7 (R1) guidelines, nitrosamines are classified as Class 1 substances, most hazardous category, based on their carcinogenic mutagenic properties. They also recognized probable human carcinogens International for Research Cancer. Since nitrosamine-induced DNA damage poses significant...
Cytarabine (Cyt) (also known as cytosine arabinoside (ara-C)) used in the treatment of acute myeloid leukemia (AML), lymphocytic (ALL). CYT applied high doses for can cause renal failure. Monitoring excreted urine drug levels help kidney For this reason, a method was developed and validated by HPLC-MSMS analysis, which is not included literature. In study, liquid chromatography (HPLC) with triple quadrupole Mass Spectrometric (MS/MS) determination Cyt from toxicokinetic evaluation. Positive...
Personalized therapy (PM) has the potential to adapt treatment with best response and highest safety provide better patient care. Key data is drug concentration of biological materials such as plasma serum.Individual means, choice a its dose regime should fit every individual specifically. Thus efficacy would improve significantly. When developing an analytical method for (Therapeutic monitoring) TDM, it important choose clinically relevant calibration range. This quantitation range be built...