A5051764835- Cancer Mechanisms and Therapy
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Implant and Reconstruction
- Signaling Pathways in Disease
- S100 Proteins and Annexins
- Radiation Dose and Imaging
- Epigenetics and DNA Methylation
- Machine Learning in Bioinformatics
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Radiopharmaceutical Chemistry and Applications
- Protease and Inhibitor Mechanisms
- Medical Malpractice and Liability Issues
- Esophageal Cancer Research and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Thyroid Cancer Diagnosis and Treatment
- Patient Safety and Medication Errors
- Artificial Intelligence in Healthcare and Education
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Glutathione Transferases and Polymorphisms
- MicroRNA in disease regulation
Yuhuangding Hospital
2018-2024
Qingdao University
2018-2024
Shandong University
2020
Cardiff University
2020
ORCID
2020
Ningxia Medical University
2018
Breast cancer (BC) is a malignancy with high incidence among women in the world. This study aims to screen key genes and potential prognostic biomarkers for BC using bioinformatics analysis. Total 58 normal tissues 203 were collected from three Gene Expression Omnibus (GEO) gene expression profiles, then differential expressed (DEGs) identified. Subsequently, Ontology (GO) function Kyoto Encyclopedia of Genes Genome (KEGG) pathway analyzed investigate biological DEGs. Additionally, hub...
Although T-cell immunoglobulin and mucin-domain containing molecule-3 (Tim-3) has been recognized as a promising target for cancer immunotherapy, its exact role in breast not fully elucidated.Tim-3 gene expression prognostic significance were analyzed. Associated mechanisms then explored vitro by establishing Tim-3-overexpressing cells.In pooled analysis of The Cancer Genome Atlas (TCGA) database, Tim-3 levels significantly higher (P<0.001) tissue, compared with normal tissues. was prognosis...
Background: Chemoresistance remains one of the obstacles to overcome in treatment breast cancer. S100 calcium-binding protein P (S100P) has been observed be overexpressed several cancers and associated with drug resistance, metastasis, prognosis. However, role S100P chemoresistance cancer not thoroughly determined. Methods: Immunohistochemistry was used evaluate expression level 22 pairs (pre-chemo post-chemo) tissue from patients who underwent neoadjuvant chemotherapy. The influence on...
Abstract Elderly patients are susceptible to postoperative infections with increased mortality. Analyzing a deep learning model, the perioperative factors that could predict and/or contribute may improve outcome in elderly. This was an observational cohort study 2014 elderly who had elective surgery from 28 hospitals China April June 2014. We aimed develop and validate learning-based predictive models for 1510 were randomly assigned be training dataset establishing models, 504 used...
Seroma formation is a common complication in breast cancer patients undergoing mastectomy, and it negatively affects patient recovery after surgery. The present study aimed to evaluate simple method using fascia suture technique fix the flap reduce incidence of seroma.A single-center, prospective, randomized controlled trial was carried out among 160 who had undergone mastectomy from May 2018 September 2019. All were randomly divided into group (n = 80) or control followed up for at least 3...
Abstract As a negative immune checkpoint molecule, T-cell immunoglobulin domain and mucin containing molecule-3 (Tim-3) has been found to serve crucial role in escape tumour progression. Previous studies have reported that Tim-3 is important endothelial cells it also demonstrated be involved numerous types of human diseases, including melanoma, lymphoma, rickettsial infection atherosclerosis; however, its exact mechanism action remains largely unknown. In the present study, was overexpressed...
Breast cancer (BC) has high morbidity, with significant relapse and mortality rates in women worldwide. Therefore, further exploration of its pathogenesis is great significance. This study selected therapy genes possible biomarkers to predict BC using bioinformatic methods. To this end, the examined 21 healthy breasts along 457 tissues two Gene Expression Omnibus (GEO) datasets then identified differentially expressed (DEGs). Survival-associated DEGs were screened Kaplan-Meier curve. Based...
The relationship between imaging features and nonsentinel lymph node (NSLN) metastasis is not clear.To determine whether could predict NSLN in sentinel (SLN)-positive breast cancer patients to provide new clues for avoiding unnecessary axillary dissection.171 with clinically negative nodes a pathologically positive SLN were recruited January 2007 2014. According the Breast Imaging Reporting Data System (BI-RADS), effects of clinicopathological factors, especially features, on metastases...
Recently, increasing studies have shown that non-coding RNAs are closely associated with the progression and metastasis of cancer by participating in competing endogenous RNA (ceRNA) networks. However, role survival-associated ceRNAs breast (BC) remains unknown.The Gene Expression Omnibus database The Cancer Genome Atlas BRCA_dataset were used to identify differentially expressed RNAs. Furthermore, circRNA-miRNA interactions predicted based on CircInteractome, while miRNA-mRNA TargetScan,...
Abstract Background To explore the capability and clinical significance of chest thin-section computed tomography (CT) for localization mammographically detected clustered microcalcifications. Methods A total 69 patients with 71 microcalcifications received surgical biopsy under guidance mammography (MG), CT was used to localize calcifications combined MG if can be seen on CT. Intraoperative specimens were performed in all cases identification resected The clinical, imaging pathological...
Abstract Background: T-cell immunoglobulin and mucin-domain containing molecule-3 (Tim-3) has been recognized as a promising target for cancer immunotherapy, but its exact role in breast not fully elucidated. Methods: The gene expression level of Tim-3 prognostic significance were analysed. In vitro functions associated mechanisms then explored through establishing overexpressing cells. Results: was significantly higher (p<0.001) tissue compared to normal following pooled analysis TCGA...
Breast cancer (BC) is the most common in women worldwide and has a high mortality rate. The fact that tumor microenvironment affects clinical outcomes of all types cancers underlines involvement various immune-related genes (IRGs). Therefore, this study aimed to establish an IRGs-based signature for prognosis BC patients.In study, 12 immune cell infiltrating degrees 1,102 cases from Cancer Genome Atlas (TCGA) database were assessed, RNA-sequencing (RNA-seq) data these samples analyzed by...
Abstract Background: T-cell immunoglobulin and mucin-domain containing molecule-3 (Tim-3) has been recognized as a promising target for cancer immunotherapy, but its exact role in breast not fully elucidated. Methods: The gene expression level of Tim-3 prognostic significance were analysed. In vitro functions associated mechanisms then explored through establishing overexpressing cells. Results: was significantly higher (p<0.001) tissue compared to normal following pooled analysis the...
Abstract Background: Breast cancer (BC) is a malignancy with high incidence among women in the world, and it very urgent to identify significant biomarkers molecular therapy methods . Methods: Total 58 normal tissues 203 were collected from three Gene Expression Omnibus (GEO) gene expression profiles, differential expressed genes (DEGs) identified. Subsequently, Ontology (GO) function Kyoto Encyclopedia of Genes Genome (KEGG) pathway analyzed. Additionally, hub screened by constructing...