Cancer, ranks as the secondary cause of death, is a group diseases that are characterized by uncontrolled tumor growth and distant metastasis, leading to increased mortality year-on-year. To date, targeted therapy intercept aberrant proliferation invasion crucial for clinical anticancer treatment, however, mutant expression target genes often leads drug resistance. Therefore, it essential identify more molecules can be facilitate combined therapy. Previous studies showed death associated...

DEP domain containing 1 (DEPDC1) is a novel tumor-associated and cell cycle related gene, which aberrantly expressed in multiple types of cancer involves tumorigenesis progression. Here, we examined the functional involvement underlying mechanism DEPDC1 breast cancer. In present study, immunohistochemistry results demonstrated that was high-expressed tissues compared with paired adjacent normal tissues, its tendency at protein level consistent mRNA from TCGA data. Moreover, revealed...

Bone morphogenetic proteins (BMPs) play crucial roles in the tumorigenesis and metastasis of cancers. Controversy remains about exact implications BMPs their antagonists breast cancer (BC), due to diverse complex biological functions signalling. A comprehensive study whole family signalling is provoked.Aberrant expression BMP, BMP receptors primary tumours were analysed by using TCGA-BRCA E-MTAB-6703 cohorts. Related biomarkers including ER, HER, proliferation, invasion, angiogenesis,...

Objective The purpose of this study was to determine the causal effect statins on osteoarthritis (OA) risk using Mendelian randomization (MR). Methods Single nucleotide polymorphism–based genome‐wide association analyses were collected from UK Biobank and FinnGen dataset, OA data Arthritis Research Osteoarthritis Genetics (arcOGEN) study. Two‐sample MR performed inverse‐variance weighted (IVW) technique. MR‐Egger, median, mode served as supplementary analyses. MR‐Egger regression, Cochran's...

Bone metastasis is the most common metastatic destination in advanced breast cancer, presenting a poor prognosis and clinical challenges management. To date, mechanism of bone cancer remains largely unclear.Differentially expressed genes primary tumours that developed metastases were systematically analysed using both TCGA-BRCA E-MTAB-4003 databases. Adaptive phenotype subsequent lesions was GSE46161 database. A series biomarkers including homing, immune escape, angiogenesis, factors...

Death associated protein‑3 (DAP3) was identified as a responsive protein to interferon‑gamma‑induced cell death which possibly exerts this regulation by interacting with DAP3 binding enhancer‑1 (DELE1), newly discovered mitochondrial stress in response signals. Whilst has been shown be aberrantly expressed several cancer types (i.e. breast cancer), little is known about the relationship between and DELE1 cancers. The present study examined expression levels of both clinical colorectal...

Objective The present study aimed to investigate the involvement of aberrant BMP8A expression in TNBC and bone metastasis. Methods Aberrant breast cancer was first determined by analyzing Cancer Genome Atlas cohort (TCGA-BRCA) an immunohistochemical (IHC) staining a tissue microarray (TMA). Clinical relevance deregulated assessed using Kaplan-Meier online analysis. influence on cellular functions two cell lines vitro assays. Conditional medium (CM) collected from supernatant hFOB cells...

Background: Death associated proteins (DAPs) are involved in the apoptosis of various cell types response to interferon gamma, including cancer cells. The present study assessed both DAP1 and DAP3 human pancreatic cancer. Materials Methods: transcripts were quantitatively analysed tumour tissues paired adjacent normal using real time PCR followed by statistical analyses for their clinical implications. Results: Levels markedly higher than tissues, whereas had lower levels versus tissues....

Abstract Background To explore the capability and clinical significance of chest thin-section computed tomography (CT) for localization mammographically detected clustered microcalcifications. Methods A total 69 patients with 71 microcalcifications received surgical biopsy under guidance mammography (MG), CT was used to localize calcifications combined MG if can be seen on CT. Intraoperative specimens were performed in all cases identification resected The clinical, imaging pathological...

Capillary morphogenesis gene 2 (CMG2) mediates cell–matrix interactions to facilitate cell adhesion and migration. CMG2 has been implicated in the disease progression of breast cancer, prostate cancer gastric cancer. The present study aims determine role peritoneal metastasis pancreatic Pancreatic tumour samples were collected from Peking University Cancer Hospital. expression was determined using quantitative PCR. After creation knockdown overexpression cells, effect on several functions...

Background: The present study was designed to investigate the safety and effectiveness of iced normal saline combined with cocktail perfusion during total knee arthroplasty (. This a random, double-blind, parallel-group conducted in China.Methods: Seventy patients undergoing unilateral replacements were assessed. Among them, sixty confirmed primary osteoarthritis stage IV recruited divided into three groups randomly, different intro-operative articular cavity treatments given according...

Objective To determine if the anteromedial portal (AMP) is better than transtibial approach (TT) in terms of clinical function, knee joint stability, femoral tunnel length and location. Methods From August 2010 to July 2013 , 104 patients who underwent anterior cruciate ligament reconstruction Yantai Yuhuangding Hospital were enrolled. Inclusion criteria: at least one year post-operative follow-up, normal contralateral joint, no serious postoperative complications, three-dimensional...

Abstract Objective To determine the value of scintillation sign from Magnetic Resonance (MR) in assessing tear rotator cuff before operation. Method Preoperative MRI 52 cases were system reviewed, two independent imaging physicians invited to read results. The results further confirmed by interoperative observations arthroscope. Statistical analysis was performed estimate sensitivity and specificity sign. Result are relatively high stable, when used between different physician or same at...

Abstract Trial design: The present study was designed to investigate the safety and effectiveness of iced normal saline combined with cocktail perfusion during total knee arthroplasty (TKA). This a random, double-blind, parallel-group conducted in China. Methods: Seventy patients undergoing unilateral replacements were assessed study. Among them, sixty confirmed primary osteoarthritis stage IV recruited divided into three groups randomly, different intro-operative articular cavity treatments...

Abstract Objective: The present study was designed to investigate the safety and effectiveness of iced normal saline combined with cocktail perfusion during total knee arthroplasty (TKA). This a random, double-blind, parallel-group conducted in China. Methods : Seventy patients undergoing unilateral replacements were assessed study. Among them, sixty confirmed primary osteoarthritis stage IV recruited divided into three groups randomly, different intro-operative articular cavity treatments...

Abstract Introduction Role of Bone morphogenetic protein 8A (BMP8A) and BMP receptors (BMPRs) in the tumourigenesis progression breast cancer remains elusive. Present study aims to investigate expression BMP8A related BMPRs their clinical implication. Method Expression was analysed using RNA sequencing data TCGA cohort. Findings were further validated a meta gene array dataset (E-MDTA6703, n = 2302). STRING applied explore predicted BMP8A. Clinical relevance deregulated assessed both ANOVA...

Abstract Background : The present study was designed to investigate the safety and effectiveness of iced normal saline combined with cocktail perfusion during total knee arthroplasty (TKA). Method Sixty patients undergoing TKA were divided into three groups, then different intro-operative articular cavity treatment given according randomized, double-blind controlled rule. One way ANOVA analysis on visual analogue scale (VAS) score, functional recovery, drainage, edema affected limb performed...

<h3>Introduction</h3> Death association protein-3 (DAP3) was discovered as a responsive protein to interferon-gamma induced cell death and may exert this regulation by interacting with DELE1 (DAP3 Binding Cell Enhancer 1) (also known KIAA0141), newly mitochondrial stress in response signals. Whilst DAP3 has been shown be aberrantly expressed limited number of solid tumours, eg. breast cancer haematological malignancies (leukaemia), little is about the relationship between other cancers. The...

<h3>Introduction</h3> Aberration of MLN64 (Metastatic Lymph Node Protein 64), also known as StARD3 (StAR Related Lipid Transfer Domain Containing 3), has been reported in endocrine related cancers including breast and prostate found to be present insulinoma cells. The study evaluated the clinical prognostic values clarify its role human pancreatic cancer. <h3>Methods</h3> Human cancer cell lines, PANC1 MIA PaCa-2 were used. levels gene transcripts quantitatively a cohort with matched normal...