A5023197218- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Neutropenia and Cancer Infections
- Advances in Oncology and Radiotherapy
- Economic and Financial Impacts of Cancer
- Frailty in Older Adults
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Acute Myeloid Leukemia Research
- Breast Cancer Treatment Studies
- Acute Lymphoblastic Leukemia research
- Lung Cancer Diagnosis and Treatment
- Pain Management and Opioid Use
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Childhood Cancer Survivors' Quality of Life
- Cancer Risks and Factors
- Ethics in medical practice
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Amino Acid Enzymes and Metabolism
Roswell Park Comprehensive Cancer Center
1989-2021
Imperial College London
2020
GlaxoSmithKline (United States)
2020
University at Buffalo, State University of New York
1977-2017
Institute for Advanced Studies in Aging and Geriatric Medicine
2012-2014
University of Maryland, Baltimore
2014
Mayo Clinic in Arizona
2014
University of Illinois Chicago
2014
Illinois College
2014
Harvard University
2014
The Karnofsky Performance Status Scale (KPS) was designed to measure the level of patient activity and medical care requirements. It is a general independence has been widely used as assessment patients with cancer. Although there long history use KPS for judging cancer patients, its reliability validity have assumed without formal investigation. interrater investigated in two ways, both which gave evidence moderately high reliability. evaluated their home were usually assigned lower score...
BACKGROUND Colon carcinoma primarily affects older-aged persons 65 years and older. Seventy-five percent of the incident tumors affect in this age group. Because their advanced age, older patients already may be coping with other concomitant major physical illnesses. This article documents preexisting diseases colon at diagnosis evaluates effects comorbidity burden on early mortality. METHODS Prevalence comorbid conditions was assessed by a retrospective medical records review an...
Over 43% of the newly diagnosed breast cancers in US occur women 65 years or older. Yet little attention is devoted to age-associated aspects this malignancy. This study uses data on more than 125,000 from 1973 1984 examine influence advancing age cancer. The National Cancer Institute's Surveillance, Epidemiology, and End Results Program provides information disease stage, surgery, histologic type, survival time compare contrast all groups. Women who present initially with distant are likely...
We reviewed 1808 hospital charts representing virtually all patients given a diagnosis of non-small-cell lung cancer in New Hampshire and Vermont between 1973 1976 found that the treatment varied according to their marital status, medical insurance coverage, proximity cancer-treatment center. Patients were more likely be treated with surgery if they married (odds ratio, 1.67; 95 percent confidence interval, 1.08 2.57) or had private (1.52; 1.03 2.26). Among who did not have surgery, those...
To determine the relation between breast self-examination performance and clinical pathological stage of cancer at first diagnosis, we studied 335 patients with cancer. Approximately one fourth reported that they had been practicing monthly self-examination, half never practiced self-examination. More frequent was associated more favorable fewer axillary-lymph-node metastases on histologic examination. On examination, age-adjusted maximum tumor diameter 1.97 +/- 0.22 cm (mean S.E.M.) as...
To study the clinical efficacy of granulocytes obtained by filtration leukapheresis, patients with clinically evident infection and granulocyte counts < 500 per cubic millimeter were randomly assigned to receive conventional therapy alone or a transfusion from single donor each day for four days. Five 19 control survived 20, 15 17 in transfused group survived. Comparison two populations variables such as age, disease, severity type revealed no other factor that could account difference...
Abstract Data on religious belief, activity, and connections, ratings of happiness, life satisfaction, pain level were obtained periodically from 71 patients with advanced cancer. Religious belief showed substantial positive correlation activity connections significantly correlated both happiness satisfaction. also reported lower levels pain, even though they no less likely to report the presence pain. 36 who have since died show between religion variables duration survival. In general,...
BACKGROUND Acute myeloid leukemia (AML) is the common form of acute in adults, accounting for over 80% all leukemias individuals aged >18 years. Overall 5‐year survival remains poor older AML patients; it <5% patients >65 In this study, authors examined whether has improved subsets geriatric 3 successive decades. METHODS Surveillance, Epidemiology and End Results (SEER) data were used to determine trends relative by age among 19,000 with decades (1977‐1986, 1987‐1996, 1997‐2006)....
A prospective study of infectious morbidity in patients with acute myelocytic leukemia receiving chemotherapy was undertaken to test the effects a reduction ambient and/or endogenous microorganisms. Patients were randomly allocated receive: (1) neither barrier isolation nor antimicrobial suppression; (2) suppression (gentamicin, vancomycin, and nystatin) conventional ward reverse isolation; (3) filtered air; or (4) isolation, air, suppression. The presence infection at time randomization...
The authors identified all newly diagnosed lung cancer cases in New Hampshire and Vermont for the period 1973 through 1976 abstracted clinical data on presenting symptoms findings from their hospital records. Microscopy slides were also reviewed, when possible, to confirm cell type. most frequent weight loss (46%) cough (45%). Other common dyspnea (37%), weakness (34%), chest pain (27%), hemoptysis (27%). presence of was general related disease stage but bore little relationship These...
Abstract Multicentric reticulohistiocytosis (MR) is a syndrome characterized by papulonodular skin lesions, debilitating polyarthritis, and characteristic histologic findings. It rare disorder with only 82 cases reported. Twenty‐eight percent had an associated neoplasm. Hematologic malignancies (four) neoplasms arising from the breast (four), cervix (three), stomach ovary (two), colon lung (one), pleura unknown source (two) were all seen MR. Eleven (including our own) available for review....
Summary Remission duration associated with the administration of conventional maintenance chemotherapy to patients acute myelogenous leukaemia was evaluated. The records 760 who entered remission between 1974 and 1979 were reviewed. median 1.1 years 16% remaining in at 8 years. relapse curve biphasic a high rate during first 2½ followed by much lower thereafter. Leukaemic relapses noted through remission. A plateau phase indicating freedom from risk leukaemic recurrence is not clearly...
Identified were 1,906 cases of confirmed lung cancer that occurred among all residents New Hampshire and Vermont over a 4-year period. Medical records, pathologists' reports, and, when possible, pathology slides obtained reviewed to assign specific histologic diagnosis. The diagnosis made by the original pathologist was generally upon review, except for large cell undifferentiated type which appeared be an unreliable classification. Among men at ages incidence rates squamous far exceeded...
Fifty-two patients under chemotherapeutic treatment for relapse of acute leukemia were studied psychological response and adaptation to isolation in "germ-free" or laminar air-flow rooms. Psychological assessment was obtained by use a rating scale based on nurses' observations, forced-choice questionnaire, clinical record, diaries kept the units. Patients general adapted protected environment maintained their stability over time. This related part receiving intensive individualized nursing...
The Community Hospital Oncology Program (CHOP), funded under contracts by the National Cancer Institute (NCI) from 1981 to 1984, was designed be a model for delivery of most up-to-date cancer care in community setting. Site specific patient management guidelines (PMGs) were developed physicians who saw majority patients each and represent consensus current information on pretreatment evaluation site. There potential PMGs have strong effect physician practice patterns. A patterns study (POC)...