A5102923320- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Surgical site infection prevention
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Bone fractures and treatments
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Shoulder and Clavicle Injuries
- Nerve Injury and Rehabilitation
- Infectious Diseases and Tuberculosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Lower Extremity Biomechanics and Pathologies
- Patient-Provider Communication in Healthcare
- Antimicrobial Resistance in Staphylococcus
- Sarcoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
Orthopaedic Hospital Speising
2021-2025
Orthopaedic Research
2022
Ludwig Boltzmann Institute of Osteology
2021
Hanusch Hospital
2021
The plasma levels of tissue-specific microRNAs can be used as diagnostic, disease severity and prognostic biomarkers for chronic acute diseases drug-induced injury. Thereby, the combination diverse into biomarker signatures using multivariate statistics seems especially powerful from perspective tissue condition specific microRNA shedding plasma. Although next-generation sequencing (NGS) technology enables one to analyse circulating on a genome-scale level, it suffers potential biases (e.g.,...
Abstract Purpose Despite advances of three-dimensional imaging pelvic radiographs remain the cornerstone in evaluation hip joint. However, large inter- and intra-rater variabilities were reported due to subjective landmark setting. Artificial intelligence (AI)–powered software applications could improve reproducibility radiograph by providing standardized measurements. The aim this study was evaluate reliability agreement a newly developed AI algorithm for radiographs. Methods Three-hundred...
Aims This study aimed to evaluate the BioFire Joint Infection (JI) Panel in cases of hip and knee periprosthetic joint infection (PJI) where conventional microbiology is unclear, assess its role as a complementary intraoperative diagnostic tool. Methods Five groups representing common microbiological scenarios revision arthroplasty were selected from our registry, prospectively maintained PJI databases, biobank: 1) unexpected-negative cultures (UNCs), 2) unexpected-positive (UPCs), 3)...
Abstract Objectives The unique properties of dalbavancin (DAL) emphasize the need to explore its clinical benefits treat periprosthetic joint infections (PJIs). present study aimed compare treatment outcome with Standard Care (SoC) in hip and knee PJIs. Methods Eighty-nine patients were selected for each group this based on our prospectively maintained PJI database. A 1:1 propensity score-matching was performed between who received at least two doses those SoC. Patients matched demographics,...
Spontaneous neck fractures are feared complications of cephalomedullary nail removal after successful healing per- and subtrochanteric fractures. To date, the initial postoperative stability as well correct weightbearing regimen remain unclear. The aim this biomechanical ex vivo study was to evaluate failure load hardware specimens, which received nails during their lifetime. A total 20 specimens voluntary body donors were included in study. Group 1 (n = 10) consisted that lifetime due or...
Periprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty. Staged revision surgery considered effective in eradicating PJI. We aimed to determine the rate resolution after each stage staged (first stage, repeat first second excision arthroplasty, and reimplantation) assess functional outcomes mortality at ten years consecutive series 30 chronic PJI arthroplasties. Infection was defined as no clinical nor laboratory evidence 24 months last minimum 12 following...
The aim of this study was to evaluate the number primary and revision total joint arthroplasties (TJA/rTJA) in 2020 compared 2019. Specifically, first second waves COVID-19 pandemic were evaluated as well pre-operative test. A cross-sectional single-center our prospectively maintained institutional arthroplasty registry performed. wave led a socioeconomic lockdown 2020. Performed surgeries, cause revision, age, gender, American Society Anesthesiologists-level analyzed. Preoperative testing...
Abstract Background Prosthetic joint infection (PJI) caused by Candida spp is a severe complication of arthroplasty. We investigated the outcomes PJI. Methods This was retrospective observational multinational study including patients diagnosed with Candida-related PJI between 2010 and 2021. Treatment outcome assessed at 2-year follow-up. Results A total 269 were analyzed. Median age 73.0 (interquartile range [IQR], 64.0–79.0) years; 46.5% male 10.8% immunosuppressed. Main sites hip (53.0%)...
Abstract The use of robotic-assisted surgery (RAS) in total knee arthroplasty (TKA) is becoming increasingly popular due to better precision, potentially superior outcomes and the ability achieve alternative alignment strategies. most commonly used strategy with RAS a modification mechanical (MA), labeled adjusted MA (aMA). This allows slight joint line obliquity tibial component balancing. In present study, we compared coronal after TKA using aMA computer-assisted (CAS) that has been...
Aim Candida species are uncommon pathogens causing prosthetic joint infection (PJI). This study evaluated the surgical management and outcome of PJI. Methods Patients with EBJIS Definition confirmed PJI, due to species, from 19 medical centres were assessed. Demographic, diagnostic, treatment data collected. Results 269 patients recruited follow-up for at least one year. Mean age was 70.2 years (+/- 12.4) 10.8% being immunocompromised. The most common fungal C. albicans (55.8%), parapsilosis...
In recent years, total hip arthroplasty via the direct anterior approach (DAA) has become more common. Little is known on influence of surgical microbiological spectrum and resistance pattern in periprosthetic joint infections. The aim present study was to evaluate infections comparing versus lateral a matched-cohort analysis at single institution.Patients who underwent revision due PJI following primary with culture positive microbiology were analyzed. all patients, both surgery revisions...
The increasing incidence of antimicrobial resistance (AMR) is a major global challenge. Routine techniques for molecular AMR marker detection are largely based on low-plex PCR and detect dozens to hundreds markers. To allow comprehensive sensitive profiling markers, we developed capture-based next generation sequencing (NGS) workflow featuring novel panel the curated database ARESdb. Our primary objective was compare sensitivity target enrichment-based metagenomics sequencing. Therefore,...
Resection arthroplasty can be performed as the first stage of a two-stage procedure in some patients with severe periprosthetic hip joint infections poor bone stock. This retrospective study aimed to evaluate factors associated subsequent failure or success these patients. Between 2011 and 2020; 61 (26.4%) 231 who underwent protocol infections; no spacer was used stage. The minimum follow-up period 12 months. Patient's demographics various infection risk were analyzed. In total, 37/61...
Scapulothoracic orientation, especially scapular internal rotation (SIR) may influence range of motion in reverse total shoulder arthroplasty (RTSA) and is subjected to body posture. Clinical measurements SIR rely on apical bony landmarks, which depend changes scapulothoracic while radiographic are often limited by the restricted field view (FOV) CT scans. Therefore, goal this study was (1) determine whether use scans with a FOV measure reliable (2) if clinical measurement could be valuable...