We investigated the relationship between toxic effects of metal wear particles and their ability to stimulate release inflammatory mediators implicated in bone resorption. In vitro studies were carried out with use rat peritoneal macrophages, which exposed either cobalt-chromium-alloy or titanium-aluminum-vanadium particles, milled from components hip prostheses. The size-range of, at concentrations similar to, those found tissues surrounding failed prostheses humans. showed little toxicity...

Resorption of bone and the formation a membrane at interface between acrylic cement were induced by particles high-density polyethylene that similar in size to those are present tissues surrounding human joint prosthesis. A non-weight-bearing plug methylmethacrylate was inserted through knee into distal part femur rat. The rapidly became surrounded shell bone. After repeated injections joint, resorption occurred this stable interface. No after opposite injected with control preparation did...

Background: The use of larger femoral heads has been proposed to reduce the risk dislocation after total hip arthroplasty, but there is a lack evidence support this proposal. aim multicenter randomized controlled trial was determine whether incidence one year arthroplasty significantly lower in association with 36-mm head articulation as compared 28-mm articulation. Methods: Six hundred and forty-four middle-aged elderly patients undergoing primary or revision were intraoperatively receive...

Our aim was to determine whether in vitro studies would detect differences the cellular response wear particles of two titanium alloys commonly used manufacture joint replacement prostheses. Particles were order 1 microm diameter representative those found adjacent failed Exposure human monocytes 6-aluminium 4- vanadium (TiAlV) at concentrations 4 x 10(7) particles/ml produced a mean prostaglandin E2 release 2627.6 pM; this significantly higher than 317.4 pM induced by 7-niobium alloy...

Operative grading of loosening and histologic examination the periprosthetic tissues femoral acetabular bone-cement interfaces were undertaken in 72 revised resurfacing hip arthroplasties. By correlating degree macroscopic microscopic at interface, a classification stages interface was devised. Examination solidly fixed prosthesis components has demonstrated presence polyethylene wear particles macrophage response prior to loosening. This suggests that may migrate along are both...

This volume consists of about 300 papers presented at the 1972 EMCON European Regional Conference on Electron Microscopy held in Manchester. Since reviewer was a contributor this review cannot be entirely disinterested!

The objective of this workshop was to provide a forum discuss the reintroduction metal on bearings for clinical use in total hip arthroplasty. Approximately 100 researchers clinicians, and industry representatives presented state art interpretation replacement's past performance, clinical, tribologic, biologic considerations all bearings. Based scientific presentations at symposium, extant literature, experience panelists, current regulatory, legal, economic environment, consensus statements...

The periacetabular osteotomy is a well established surgical procedure for the preventative treatment of degenerative joint disease caused by symptomatic acetabular dysplasia. Surgeons on several continents use varying approaches to achieve same effective osteotomy. Individual must provide accurate and adequate exposure reorientation fragment. aim approach such complex expansive surgery minimize morbidity related approach. This article compares experiences among three common including...

The literature on animal and cellular models used to study the response cobalt chrome alloy implants wear corrosion products is reviewed. Animal studies show that in solid form relatively well tolerated. Injections of large numbers particles a single bolus lead acute inflammation necrosis, followed by chronic inflammatory response. Macrophages are predominant cell type may persist tissues for years. Long term have failed confirm induction tumors. In vitro toxic effects particles, especially...

We report a prospective randomly controlled trial to examine the effectiveness of continuous passive motion (CPM) in improving postoperative function and range movement after total knee arthroplasty (TKA). allocated 53 patients (57 knees) one three regimes: no CPM (n = 19); at 0 40 degrees (0 CPM; n 18); 70 20). Those groups had for 48 hours all an identical regime physiotherapy. There was even distribution various cemented cementless TKAs each group. Patients were assessed preoperatively...

Particles of prosthetic material stimulate macrophages to release cytokines, which may cause bone loss and loosening the prosthesis. This study investigates possibility that particles different materials induce cytokines thus have effects on remodeling. The in vitro response human monocytes cast forged cobalt chrome alloy, stainless steel, titanium aluminum vanadium alloy were compared. There was no difference biologic cobalt-chrome derived from or material. Cobalt-chrome toxic cells, but...

In a prospective study of 100 consecutive Wagner resurfacing hip arthroplasties in ninety-three patients, the outcomes for all hips were determined an eight to ten-year follow-up period. By survivorship analysis, rate survival arthroplasty was calculated be 70 per cent at five years, but only 40 years. The major cause failure aseptic loosening acetabular or femoral component, both. Fracture neck femur occurred three hips. Although medium-term results (at fifty-six eighty-three months) better...

The intraarticular effects of alloy wear particles similar in size to those present the tissues around loose total joint prostheses were studied rat knee joints injected with laboratory-prepared particulate cobalt-chrome. induced rapid proliferation macrophages and focal degeneration synovial response seen articular humans. Bacteriologic tests excluded infection as a factor. Wear may contribute changes bone resorption resulting prosthetic loosening. Experiments on animals provide useful...

We reviewed the technetium phosphate scans of 280 patients who had been referred with a clinical diagnosis osteomyelitis in order to establish diagnostic accuracy this procedure. Strict criteria were established define two subgroups: one proved and definitely did not have osteomyelitis. The scan correctly identified at fifty-five sixty-two sites, was negative seventy-four seventy-nine without distinguished all cases cellulitis or soft-tissue abscess from osteomyelitis, but eight thirty-nine...

Abstract Porous tantalum (Ta) has found application in orthopedics, although the interaction of human osteoblasts (HOB) with this material not been reported. The aim study was to investigate primary HOB porous tantalum, using 5‐mm thick discs tantalum. Comparison made solid and tissue culture plastic. Confocal microscopy used attachment growth cells on Ta, showed that attached successfully metal “trabeculae,” underwent extensive cell division, penetrated into Ta pores. maturation determined...

We dissected 20 cadaver hips in order to investigate the anatomy and excursion of trochanteric muscles relation posterior approach for total hip replacement. String models each muscle were created their measured while femur was moved between its anatomical position dislocated position. The determined by computer navigation. In contrast previous studies which showed a separate insertion piriformis obturator internus, our findings indicated that inserted onto superior anterior margins greater...