Claudia Zielke

ORCID: 0000-0003-4654-4903
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About
Contact & Profiles
Research Areas
  • Food composition and properties
  • Field-Flow Fractionation Techniques
  • Polysaccharides Composition and Applications
  • Proteins in Food Systems
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Microbial Metabolites in Food Biotechnology
  • 3D Printing in Biomedical Research
  • Analytical Chemistry and Chromatography
  • Various Chemistry Research Topics
  • Chemical Thermodynamics and Molecular Structure
  • Phase Equilibria and Thermodynamics
  • Electrowetting and Microfluidic Technologies
  • Scientific Measurement and Uncertainty Evaluation
  • Career Development and Diversity
  • Alzheimer's disease research and treatments
  • Advanced Biosensing Techniques and Applications
  • Molecular Junctions and Nanostructures
  • Signaling Pathways in Disease
  • Interdisciplinary Research and Collaboration
  • Extraction and Separation Processes
  • Semiconductor materials and interfaces
  • Antimicrobial Peptides and Activities
  • Spectroscopy and Chemometric Analyses
  • Microfluidic and Bio-sensing Technologies
  • Polysaccharides and Plant Cell Walls

Palo Alto University
2023-2024

Stanford University
2023-2024

Santa Clara University
2020-2022

Lund University
2015-2019

Faculty (United Kingdom)
2019

Engineering (Italy)
2019

Helmholtz-Zentrum Berlin für Materialien und Energie
2010-2012

Control over the size of active metal particles and structure catalysts pore system is an essential requirement for design supported catalysts. Polymeric templates combined with a suitable metal-oxide precursor enable synthesis defined systems, whereas colloidal can provide access to particle-size control. However, template, precursor, in one solution are often not compatible each other due aggregation, precipitation, dissolution processes. We present new approach preparation that permits...

10.1021/cm301081w article EN Chemistry of Materials 2012-10-01

An extraction method for mixed-linkage β-glucan from oat and barley was developed in order to minimize the effect of on structure. β-Glucan were characterized terms molecular size molar mass distributions using asymmetric flow field-flow fractionation (AF4) coupled multiangle light scattering (MALS), differential refractive index (dRI) fluorescence (FL) detection. The carbohydrate composition extracts analysed polysaccharide analysis by gel electrophoresis (PACE) high-performance...

10.1371/journal.pone.0172034 article EN cc-by PLoS ONE 2017-02-14

10.1016/j.colsurfa.2018.10.042 article EN Colloids and Surfaces A Physicochemical and Engineering Aspects 2018-10-21

10.1007/s10337-023-04261-4 article EN Chromatographia 2023-05-18

High rates of glycolysis in tumors have been associated with cancer metastasis, tumor recurrence, and poor outcomes. In this light, single cells that exhibit high are specific targets for therapy. However, the study these requires efficient tools their isolation. We use a droplet microfluidic technique developed our lab, Sorting by Interfacial Tension (SIFT), to isolate cell subpopulations based on without labels or active sorting components. By controlling flow conditions chip, threshold...

10.1021/acs.analchem.9b05738 article EN Analytical Chemistry 2020-04-16

Asymmetric flow field-flow fractionation (AF4) is a separation technique in which focusing/relaxation step used after the sample injected onto channel. During step, focused by two counter-directed flows. This allows components to establish diffusion-dependent equilibrium concentration profile. The focusing may, some cases, cause loss of due adsorption into accumulation wall (i.e. membrane) or aggregation sample. In addition, increase during may prevent complete relaxation and overloading...

10.1039/c9an00466a article EN cc-by-nc The Analyst 2019-01-01

Abstract The IR ellipsometric technique was used to identify the surface species and control preparation of maleimide‐terminated surfaces. Because higher s / n ratios for metallic substrates, protocol initially developed on Au surfaces, later successfully transferred technologically more relevant Si (111) substrates. functionalized surfaces were achieved by electrochemical deposition diazonium linker films following chemical adsorption steps. Complementary XPS also employed detect in process...

10.1002/sia.3699 article EN Surface and Interface Analysis 2010-10-20

Starch is a mixture of amylose (AMY) and amylopectin (AMP) which are different in physical properties such as molar mass (M), rms radius (<TEX>$R_g$</TEX>) hydrodynamic diameter (<TEX>$d_H$</TEX>). The rheological functional starch influenced by various factors including the molecular size, distribution (MD) concentration ratio AMY AMP. It also important to analyze proteinaceous material they affect flavor texture food added. In this study, asymmetrical flow field-flow fractionation (AF4)...

10.5806/ast.2017.30.1.1 article EN Analytical Science and Technology 2017-02-25

We present a method to photo-tag individual microfluidic droplets for latter selection by passive sorting. The use of specific surfactant leads the interfacial tension be very sensitive droplet pH. photoexcitation containing photoacid, pyranine, decrease in concurrent increase enables irradiated droplets. technique is used select within array as illuminated remain wells while other are eluted flow external oil. This was an cells at stage apoptosis. also adaptable continuous-flow By passing...

10.3390/mi11110964 article EN cc-by Micromachines 2020-10-28

Using biophysical methods, we determine that LL-37 prevents amyloid fibril formation in a dose-dependent and sequence-specific manner, by forming peptide-peptide complexes. transgenic Drosophila model with pan-neuronal expression of either or Aβ42 alone simultaneously non-expressing controls, show the impact these neuronally expressed peptides for first time vivo. Flies co-expressing significantly increased longevity compared to flies expressing only. Expression has direct on development,...

10.2139/ssrn.4718845 preprint EN 2024-01-01

10.1007/s10337-024-04315-1 article EN Chromatographia 2024-02-07

A label-free, fixation-free and passive sorting method is presented to isolate activated T-cells shortly after activation prior the display of surface markers. It uses a recently developed platform dubbed “Sorting by Interfacial Tension” (SIFT) that sorts droplets based on pH. After polyclonal (anti-CD3/CD28 bead) brief incubation chip, containing lower pH than those naive cells due increased glycolysis. Under specific surfactant conditions, change in can lead concurrent increase droplet...

10.3390/mi13091442 article EN cc-by Micromachines 2022-09-01
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