A5044512290- Diet and metabolism studies
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Dietary Effects on Health
- Pharmacological Effects and Toxicity Studies
- Bariatric Surgery and Outcomes
- Nutrition and Health in Aging
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2022-2024
Instituto de Salud Carlos III
2024
Universidad de León
2019-2024
Childhood obesity has reached epidemic levels and is a serious health concern associated with metabolic syndrome, nonalcoholic fatty liver disease, gut microbiota alterations. Physical exercise known to counteract progression modulate the composition. This study aims determine effect of 12-week strength endurance combined training program on inflammation in obese pediatric patients. Thirty-nine children were assigned randomly control or group. Anthropometric biochemical parameters, muscular...
Childhood obesity has reached epidemic levels, representing one of the most serious public health concerns associated with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). There is limited clinical experience concerning pediatric NAFLD patients, thus therapeutic options are scarce. The aim this study was to evaluate benefits exercise on gut microbiota composition functionality balance, consequent effects early onset in an vivo model. Juvenile (21-day-old) male Wistar rats...
Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so synbiotics could be therapeutic alternative. We aim to evaluate nutritional intervention together with the administration of bacteria Akkermansia muciniphila antioxidant quercetin an vivo model early NAFLD. 21-day-old rats were fed control or high-fat diet for six weeks. Then, all animals received supplemented with/without and/or A. three microbiota, NAFLD-related parameters, circulating bile acids...
Background and Aims: Recent studies suggest that mitochondrial dysfunction promotes progression to NASH by aggravating the gut‐liver status. However, underlying mechanism remains unclear. Herein, we hypothesized enhanced activity might reshape a specific microbiota signature that, when transferred germ‐free (GF) mice, could delay progression. Approach Results: Wild‐type methylation‐controlled J protein knockout (MCJ‐KO) mice were fed for 6 weeks with either control or choline‐deficient,...
Obesity is one of the main worldwide public health concerns whose clinical management demands new therapeutic approaches. Bariatric surgery most efficient treatment when other therapies have previously failed. Due to role gut microbiota in obesity development, knowledge link between bariatric and could elucidate mechanistic This study aims evaluate long-term effects faecal metagenome metabolome patients with severe obesity. Faecal blood samples were collected before four years after...
Several hepatic disorders are influenced by gut microbiota, but its role in idiosyncratic drug-induced liver injury (iDILI), whose main causative agent is amoxicillin–clavulanate, remains unknown. This pioneering study aims to unravel particular patterns of microbiota composition and associated metabolites iDILI patients amoxicillin–clavulanate (iDILI-AC). Thus, serum fecal samples from 46 were divided into three groups: healthy controls (n = 10), non-iDILI acute hepatitis 12) 24). To...
A dietary intervention with Akkermansia muciniphila and quercetin supplementation reshapes gut microbiota composition in an vivo model of early obesity related non-alcoholic fatty liver disease - Volume 80 Issue OCE2
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.