A5010850472- CAR-T cell therapy research
- Cancer Research and Treatments
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Pluripotent Stem Cells Research
- Dermatological and COVID-19 studies
- Renal and related cancers
- CRISPR and Genetic Engineering
- Hemophilia Treatment and Research
- Biopolymer Synthesis and Applications
- Biochemical and Molecular Research
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
Universidad Autónoma de Nuevo León
2018-2023
Centro de Investigación y Desarrollo
2022
Directing an antigen to the endoplasmic reticulum (ER) improves antigen-specific immune response, revealing a potentially useful strategy in cancer immunotherapy using tumor-associated antigens (TAAs). This can be achieved by fusing ER chaperone protein, such as calreticulin (CRT). We previously reported antitumor response CRT signal peptide (SP) and its retention sequence (KDEL) full-length human papillomavirus type 16 (HPV-16) E6 E7 antigens, obtaining potent antitumoral effect. In this...
The objective of the present study was to provide statewide estimates real-world effectiveness in reducing odds one primary (symptomatic COVID-19 infection) and two secondary outcomes (hospitalization severe by four vaccines BNT162b2 (Pfizer-BioNTech), ChAdOx1 (AstraZeneca), Ad5-nCoV (CanSinoBIO), CoronaVac (Sinovac Life Sciences), used Northeast Mexico. We conducted a test-negative case-control analyzed surveillance data from December 2020 August 2021. Primary attention hospitalization. Two...
Population-based immunoglobulin G (IgG) seroprevalence studies in asymptomatic individuals Latin America are scarce. The objective of the study was to estimate prevalence and geographic distribution IgG antibodies induced by natural SARS-CoV-2 infection adults, 5-8 months after first case reported a northeastern state Mexico. This population-based cross-sectional carried out Nuevo Leon during August-November 2020. Individuals ≥18 years with no previous diagnosis or symptoms suggestive...
<abstract> <p>The pH Low Insertion Peptide (pHLIP) has versatile applications in several diseases due to its differential behavior at slightly different values. pHLIP is an unstructured and peripheral membrane-associated peptide neutral α-helical transmembrane acidic Similar what happened insulin growth hormone, pHLIP´s expanding require high-yield production further scale-up usefulness. To date, synthesis of the not been reported a prokaryotic platform, mainly relying on...
Human-induced pluripotent stem cells (iPSCs) are an accessible source of adult-derived, patient-specific for use in basic research, drug discovery, disease modeling, and cell therapy. Improving the accessibility methods to obtain iPSCs regardless can enhance their clinical application. Therefore, our purpose is report a simple protocol iPS-like from urine-derived renal epithelial (RECs) using different extracellular matrices transfection reagents. In this study, we began by culturing healthy...