A5062483842- Coral and Marine Ecosystems Studies
- Marine Ecology and Invasive Species
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Marine Invertebrate Physiology and Ecology
- Statistical Methods in Clinical Trials
- Medical and Biological Sciences
- Marine and fisheries research
- Estrogen and related hormone effects
- Optimal Experimental Design Methods
- Meta-analysis and systematic reviews
- Environmental DNA in Biodiversity Studies
- Species Distribution and Climate Change
- Child and Adolescent Psychosocial and Emotional Development
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Identification and Quantification in Food
- Health Systems, Economic Evaluations, Quality of Life
- Fish Ecology and Management Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Lymphoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- HER2/EGFR in Cancer Research
- Parasite Biology and Host Interactions
- Coastal and Marine Management
Johns Hopkins University
2025
University of Alberta
2019-2024
University of Auckland
2024
Statistical Research (United States)
2016-2023
Swansea University
2023
Children's Mercy Hospital
2023
University of Pittsburgh
2022
Pacific University
2019-2021
Stanford University
2016-2021
Reef Environmental Education Foundation
2017-2021
The cell-surface molecule CD40 activates antigen-presenting cells and enhances immune responses. is also expressed by solid tumors, but its engagement results in apoptosis. CP-870,893, a fully human selective agonist monoclonal antibody (mAb), was tested for safety phase I dose-escalation study.Patients with advanced tumors received single doses of CP-870,893 intravenously. primary objective to determine the maximum-tolerated dose (MTD). Secondary objectives included assessment modulation...
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Scientific Evidence Supports a Ban on MicrobeadsChelsea M. Rochman*†‡, Sara Kross†§, Jonathan B. Armstrong†∥, Michael T. Bogan†⊥, Emily S. Darling†#, Stephanie J. Green†¶, Ashley R. Smyth†▲, and Diogo Veríssimo†▼View Author Information† David H. Smith Conservation Research Program, Society for Biology, Washington, DC 20001, United States‡ School of Veterinary Medicine, Aquatic...
Indo-Pacific lionfish (Pterois volitans and P. miles) have spread swiftly across the Western Atlantic, producing a marine predator invasion of unparalleled speed magnitude. There is growing concern that will affect structure function invaded ecosystems, however detrimental impacts on natural communities yet to be measured. Here we document response native fish predation by populations nine coral reefs off New Providence Island, Bahamas. We assessed diet through stomach contents analysis,...
Surveyed clinicians' and researchers' perceptions of the relative usefulness prepubertal children, their mothers, teachers as informants on children's problem behavior. Findings showed a high level agreement within types surveyed. Children were seen least useful own hyperactivity, attention problems, oppositional Teachers judged superior to mothers hyperactivity/inattentiveness; these ratings reversed for child perceived more than teachers, internalizing with scoring higher children in all...
Before the introduction of tamoxifen, diethylstilbestrol (DES) was widely considered to be hormonal treatment choice in postmenopausal women with advanced breast cancer. We performed a randomized clinical trial these two agents determine their relative efficacy and toxicity. The involved 143 evaluable patients, whom 99 had received no prior systemic therapy 44 previous chemotherapy. regression rates (complete plus partial) were higher patients receiving DES (41 per cent) than those tamoxifen...
Results of estrogen receptor (ER) and progesterone (PgR) ligand-binding assays (LBAs) are strongly correlated with ER PgR by immuno-histochemistry (IHC). To investigate whether IHC also tamoxifen response, time to treatment failure (TTF) overall survival (OS), the results 2 methods were directly compared in 205 patients ER+ metastatic breast cancer treated daily (Southwest Oncology Group protocol 8228) 9 years median follow-up. pS2, another estrogen-regulated molecule, was analyzed. Tumors...
Purpose We conducted a phase II study of combination the anti–insulin-like growth factor 1 receptor antibody CP-751,871 with paclitaxel and carboplatin (PCI) in advanced treatment-naïve non–small-cell lung cancer (NSCLC). Patients Methods were randomly assigned (2:1) to 200 mg/m 2 , (area under plasma concentration-time curve 6), 10 20 mg/kg (PCI PCI ) or alone (PC) every 3 weeks for up six cycles. 10-20 patients could continue (figitumumab) treatment after chemotherapy discontinuation....
Abstract Purpose: Preclinical data indicate that expression of the ErbB family receptors, such as HER-2 and HER-1 (EGFR) may be involved in endocrine resistance. Evidence resistance from clinical studies has been inconsistent. The present study examined whether gene amplification or predicted response to tamoxifen. Patients Methods: Three hundred forty nine patients had estrogen receptor (ER)-positive breast cancer received daily tamoxifen initial therapy for advanced disease. amplification,...
Patients with Ewing sarcoma (ES) metastases and those who relapse fare poorly receive therapies that carry significant toxicity. This phase 1/2 study was conducted to evaluate the efficacy of figitumumab in advanced ES.Patients 10 18 years old were enrolled two dose escalation cohorts (20 30 mg/Kg intravenously every 4 weeks) 1 portion study. ES or older 2 The primary objective response rate (ORR).Thirty-one patients (n = 16), osteosarcoma 11), other sarcomas 4) Dose proceeded mg/kg weeks no...
The standard phase II trial problem is to decide whether or not continue the testing of a new agent (or combination). Typically, one tests null hypothesis HO: p = pO against alternative HA: pA, where probability response. There available variety two-stage designs, including optimal designs according various criteria. Practical considerations in conduct multicentre trials, however, make it difficult follow precisely. We investigate several approaches adapting stopping rules when attained...
Species invasions have a range of negative effects on recipient ecosystems, and many occur at scale magnitude that preclude complete eradication. When extirpation is unlikely with available management resources, an effective strategy may be to suppress invasive populations below levels predicted cause undesirable ecological change. We illustrated this approach by developing testing targets for the control Indo-Pacific lionfish (Pterois volitans P. miles) Western Atlantic coral reefs. first...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 433:159-167 (2011) - DOI: https://doi.org/10.3354/meps09208 Foraging behaviour and prey consumption in Indo-Pacific lionfish on Bahamian coral reefs Stephanie J. Green1,*, John L. Akins2, Isabelle M. Côté1 1Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British...
Biotic resistance, the process by which new colonists are excluded from a community predation and/or competition with resident species, can prevent or limit species invasions. We examined whether biotic resistance native predators on Caribbean coral reefs has influenced invasion success of red lionfishes (Pterois volitans and Pterois miles), piscivores Indo-Pacific. Specifically, we surveyed abundance (density biomass) lionfish predatory fishes that could interact (either through...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 472:249-256 (2013) - DOI: https://doi.org/10.3354/meps09992 Diet richness of invasive Indo-Pacific lionfish revealed by DNA barcoding Isabelle M. Côté1,2,*, Stephanie J. Green1, James A. Morris Jr.3, John L. Akins4, Dirk Steinke5 1Department Biological Sciences, Simon Fraser University, Burnaby, British...
Summary Understanding how predators select their prey can provide important insights into community structure and dynamics. However, the suite of species available to a predator is often spatially temporally variable. As result, species‐specific selectivity data are limited use for predicting novel predator–prey interactions because they assemblage specific. We present method diet selection that applicable across assemblages, based on identifying general morphological behavioural traits...