A5025075422- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
Institut d'Investigació Biomédica de Bellvitge
2021
Universitat de Barcelona
2021
The mTOR-LARP1-5′TOP axis acts at the translational level as a primary guardian of anabolic capacity cell.
The nucleotide analogue azacitidine (AZA) is currently the best treatment option for patients with high-risk myelodysplastic syndromes (MDS). However, only half of treated respond and these almost all eventually relapse. New options are urgently needed to improve clinical management patients. Here, we perform a loss-of-function shRNA screen identify histone acetyl transferase transcriptional co-activator, CREB binding protein (CBP), as major regulator AZA sensitivity. Compounds inhibiting...