Ulrich Witschi

ORCID: 0000-0003-4715-7307
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Research Areas
  • Genetic and phenotypic traits in livestock
  • Reproductive Physiology in Livestock
  • Cancer-related molecular mechanisms research
  • Reproductive Biology and Fertility
  • Animal Genetics and Reproduction
  • Sperm and Testicular Function
  • Genetic Mapping and Diversity in Plants and Animals
  • RNA modifications and cancer
  • Molecular Biology Techniques and Applications
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • RNA regulation and disease
  • Animal Behavior and Welfare Studies
  • Animal Disease Management and Epidemiology
  • Effects of Environmental Stressors on Livestock
  • Corporate Management and Leadership
  • Reproductive biology and impacts on aquatic species
  • Reproductive System and Pregnancy
  • Ruminant Nutrition and Digestive Physiology
  • Milk Quality and Mastitis in Dairy Cows
  • MicroRNA in disease regulation
  • Pancreatic function and diabetes
  • Microbial infections and disease research
  • Rabbits: Nutrition, Reproduction, Health
  • Ovarian function and disorders
  • Food Industry and Aquatic Biology

University of Zurich
2008

Cattle are ideally suited to investigate the genetics of male reproduction, because semen quality and fertility recorded for all ejaculates artificial insemination bulls. We analysed 26,090 794 Brown Swiss bulls assess ejaculate volume, sperm concentration, motility, head tail anomalies success. The heritability six traits was between 0 0.26. Genome-wide association testing on 607,511 SNPs revealed a QTL bovine chromosome 6 that associated with motility (P = 2.5 x 10−27), 2.0 10−44) 7.2...

10.1371/journal.pgen.1008804 article EN cc-by PLoS Genetics 2020-05-14

The use of sex-sorted sperm in cattle assisted reproduction is constantly increasing. However, fertility can substantially differ between unsorted (conventional) and semen batches the same sire. Sperm microRNAs (miRNA) have been suggested as promising biomarkers bull last years. In this study, we hypothesized that miRNA profile cryopreserved conventional related to after artificial insemination with X-bearing sperm. For purpose, analyzed 18 samples obtained from nine high- (HF) low-fertility...

10.1186/s12864-020-07280-9 article EN cc-by BMC Genomics 2021-01-07

Undisturbed reproduction is key for successful breeding of beef and dairy cattle. Improving reproductive ability can be difficult because antagonistic relationships with other economically relevant traits. In cattle, thorough investigation female fertility revealed unfavorable genetic correlations various production phenotypes. However, the correlation between male traits remains poorly understood. Here, we investigated among characteristics in a population Brown Swiss We performed GWAS...

10.3168/jdsc.2021-0164 article EN cc-by-nc-nd JDS Communications 2022-01-10

Abstract Background Cattle are ideally suited to investigate the genetics of male fertility. Semen from individual bulls is used for thousands artificial inseminations which fertilization success monitored. Results breeding soundness examination and repeated observations semen quality complement fertility evaluation each bull. In a cohort 3881 Brown Swiss that had genotypes at 683,609 SNPs, we reveal four novel recessive QTL on BTA1, 18, 25, 26 using haplotype-based association testing. A...

10.1186/s12864-021-07523-3 article EN cc-by BMC Genomics 2021-03-30

Abstract Background Semen quality and insemination success are monitored in artificial bulls to ensure high male fertility rates. Only ejaculates that fulfill minimum requirements processed eventually used for inseminations. We examined 70,990 from 1343 Brown Swiss identify which all were rejected due low semen quality. This procedure identified a bull produced 12 with an aberrantly small number of sperm (0.2 ± 0.2 × 10 9 per mL) mostly immotile multiple morphological abnormalities. Results...

10.1186/s12711-022-00710-0 article EN cc-by Genetics Selection Evolution 2022-03-07

Variance components (VC) were estimated for the semen production trait ejaculate volume, sperm concentration and motility in Swiss cattle breeds Brown (BS), Original Braunvieh (OB), Holstein (HO), Red-Factor-Carrier (RF), Red (RH), Fleckvieh (SF) Simmental (SI). For this purpose, traits from 2,617 bulls with 124,492 records used. The data collected years 2000-2012. model genetic parameter estimation across all included fixed effects age of bull at collection, year month number collection per...

10.1111/rda.13492 article EN Reproduction in Domestic Animals 2019-06-17

High-quality data are essential for veterinary surveillance systems, and their quality can be affected by the source method of collection. Data recorded on farms could provide detailed information about health a population animals, but accuracy farmers is uncertain. The aims this study were to evaluate animal 97 Swiss dairy farms, compare obtained different recording obtain baseline animals farms. collected from year. Their was evaluated assessing completeness information, comparing farmers'...

10.1136/vr.163.8.241 article EN Veterinary Record 2008-08-01

Abstract Cattle are ideally suited to investigate the genetics of male reproduction, because semen quality and fertility recorded for all ejaculates artificial insemination bulls. We analysed 26,090 794 Brown Swiss bulls assess ejaculate volume, sperm concentration, motility, head tail anomalies success. The heritability six traits was between 0 0.26. Genome-wide association testing on 607,511 SNPs revealed a QTL bovine chromosome 6 that associated with motility (P = 2.5 × 10 −27 ), 2.0 −44...

10.1101/2020.01.16.907865 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-01-17

stockage sur la qualité de semence taureaux Effetto della manipolazione delle pagliette durante conservazione sulla qualità dello sperma di

10.1024/0036-7281.150.12.591 article IT Schweizer Archiv für Tierheilkunde 2008-11-25

The importance of herd health management in Switzerland, its implementation by veterinarians as well their willingness to collaborate within an Internet portal have been assessed a questionnaire. is meant serve the genetic evaluation, veterinary and obligation record treatments; it should be at disposal for all users form central database. For survey, questionnaires were sent 784 (mixed livestock practices) Switzerland. Amongst them, 217 (27.7 %) could evaluated. 125 already offer service...

10.1024/0036-7281.151.12.591 article EN Schweizer Archiv für Tierheilkunde 2009-11-27

Abstract Background Semen quality and male fertility are monitored in artificial insemination bulls to ensure high success rates. Only ejaculates that fulfill minimum requirements processed eventually used for inseminations. We examined 70,990 from 1343 Brown Swiss identify which all were rejected due low semen quality. This procedure identified a bull produced twelve with an aberrantly number of sperm (0.2±0.2 × 10 9 per ml) mostly immotile multiple morphological abnormalities. Results The...

10.1101/2021.11.19.469233 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2021-11-19

Abstract Cattle are ideally suited to investigate the genetics of male fertility. Semen from individual bulls is used for thousands artificial inseminations which fertilization success monitored. In a cohort 3881 that had genotypes at 589,791 SNPs, we reveal four novel recessive QTL fertility using haplotype-based association testing. We detect either missense or nonsense variants in SPATA16 , VWA3A, ENSBTAG00000006717 and ENSBTAG00000019919 linkage disequilibrium with QTL. A bull on BTA1...

10.1101/2020.12.11.421354 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2020-12-11
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