A5067621523- Cancer-related molecular mechanisms research
- Veterinary Oncology Research
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Vector-borne infectious diseases
- Cell Adhesion Molecules Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- Oral and Maxillofacial Pathology
- RNA modifications and cancer
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Vibrio bacteria research studies
- Infectious Diseases and Mycology
- Toxoplasma gondii Research Studies
- Microbial infections and disease research
Purdue University West Lafayette
2020-2025
Center for Cancer Research
2023-2024
The nucleoprotein (NP) is a vital target for the heterosubtypic immunity of CD8+ cytotoxic T lymphocytes (CTLs) due to its conservation among influenza virus subtypes. To further enhance cell NP, autophagy-inducing peptide C5 (AIP-C5) from CFP10 protein Mycobacterium tuberculosis was used. Mice were immunized intranasally (i.n.) with human adenoviral vectors, HAd-C5-NP(H7N9) or HAd-NP(H7N9), expressing NP an H7N9 without AIP-C5, respectively. Both vaccines developed similar levels...
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is a common and aggressive form of in dogs, closely resembling human DLBCL its clinical behavior molecular features. While CHOP chemotherapy the standard treatment, many dogs experience poor responses or early relapse, underscoring need for more comprehensive understanding disease’s underpinnings. This study aimed to investigate gene expression profiles canine identify potential biomarkers therapeutic targets. Materials Methods:...
Lymphoma is a common canine cancer with translational relevance to human disease. Diffuse large B-cell lymphoma (DLBCL) the most frequent subtype, contributing almost fifty percent of clinically recognized cases. Identifying new biomarkers capable early diagnosis and monitoring DLBCL crucial for enhancing remission rates. This research seeks advance our knowledge molecular biology by analyzing expression microRNAs, which regulate gene negatively impacting via targeted RNA degradation or...
Lymphoma is among the most common cancer in dogs. Diffuse large B-cell lymphoma (DLBCL) predominant type, accounting for up to half of all cases. Definitive diagnosis DLBCL relies on cytologic evaluation with immunophenotyping, or histopathology and immunohistochemistry when needed. A rapid specific molecular test aiding could be beneficial. Noncoding microRNAs (miRNAs) are regulators gene expression involved a variety cellular processes, including cell differentiation, cycle progression,...
Haemotropic mycoplasmas (haemoplasmas) are small pleomorphic bacteria infecting erythrocytes of several mammalian species, including human beings. No study to date has focused on the risk exposure in hunting activities, particularly natural environments highly tick-infested areas. Accordingly, present aimed assess haemoplasma occurrence complex encompassing wild boars, dogs and hunters Brazil. A total 38/65 (58.5%) boars 94/159 (59.1%) were positive by qPCR for at least one haemoplasma. All...
Nonhuman adenoviral (AdV) gene delivery platforms have significant value due to their ability elude preexisting AdV vector immunity in most individuals. Previously, we demonstrated that intranasal (IN) immunization of mice with BAd-H5HA, a bovine type 3 (BAdV3) expressing H5N1 influenza virus hemagglutinin (HA), resulted enhanced humoral and cell-mediated immune responses. The BAd-H5HA IN complete protection following the challenge an antigenically distinct compared mouse group similarly...
Hemotropic mycoplasmas (hemoplasmas) are opportunistic bacteria that attach to the erythrocyte surface, causing infectious anemia in several mammalian species, including rodents. Studies surveying native Azara's agoutis (Dasyprocta azarae) Brazil lacking. Accordingly, present study aimed assess hemoplasmas infection free-ranging from an urban environmental conservation area Curitiba, southern Brazil. Overall, 11/35 (31.43%) were positive by quantitative PCR (cycle threshold≤34.4). Sequencing...
Diffuse large B‐cell lymphoma (DLBCL) is the most prevalent subtype of non‐Hodgkin (NHL) in domestic dogs, with many similarities to its human counterpart. The progression disease rapid, and treatment must be initiated early achieve cancer remission extend life. This study examined relationship between progression‐free survival (PFS) microRNA (miRNA) expression dogs DLBCL. miRNAs are small non‐coding RNA molecules that typically regulate gene post‐transcriptionally. They involved several...
Pythium insidiosum is an infectious oomycete affecting dogs that develop the cutaneous or gastrointestinal form of pythiosis with a poor prognosis. If left untreated, may be fatal. This organism not true fungus because its cell wall and membrane lack chitin ergosterol, respectively, requiring specific treatment. Identifying challenging, as hematoxylin eosin (H&E) stain poorly P. hyphae cannot differentiated conclusively from other fungal fungal-like organisms (such Lagenidium sp.)...