A5077860738- Material Dynamics and Properties
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Pickering emulsions and particle stabilization
- Electrostatics and Colloid Interactions
- Virus-based gene therapy research
- DNA and Nucleic Acid Chemistry
- Childhood Cancer Survivors' Quality of Life
- Proteins in Food Systems
- Epigenetics and DNA Methylation
- Ionic liquids properties and applications
- Respiratory viral infections research
- Phase Equilibria and Thermodynamics
- Neurogenetic and Muscular Disorders Research
- Microtubule and mitosis dynamics
- Protein Structure and Dynamics
- Polymer Nanocomposites and Properties
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Surfactants and Colloidal Systems
- Herpesvirus Infections and Treatments
- Voice and Speech Disorders
- Ubiquitin and proteasome pathways
- Hydrogels: synthesis, properties, applications
- Mitochondrial Function and Pathology
Eastern Virginia Medical School
2023-2024
Universidad de Guanajuato
2016-2023
Lund University
2021-2023
National Institute of Standards and Technology
2021
NIST Center for Neutron Research
2021
National Institute of Standards
2021
We investigate by means of small angle neutron scattering experiments and numerical simulations the interactions inter-particle arrangements concentrated dispersions copolymer microgels across volume phase transition (VPT).
We report on the short-time dynamics in colloidal mixtures made up of monomers and dimers highly confined between two glass plates. At low concentrations, experimental measurements motion agree well with solution Navier-Stokes equation at Reynolds numbers; latter takes into account increase drag force a particle due to wall-particle hydrodynamic forces. More importantly, we find that ratio diffusion coefficient monomer center mass dimmer is almost independent both dimer molar fraction,...
We present a novel method that provides measurement of DNA pressure in viral capsids using small angle X-ray scattering (SAXS). This method, unlike our previous assay, does not require triggering genome release with receptor. Thus, it can be used to determine the existence pressurized state wide range virus systems, even if receptor is known, leading better understanding processes uncoating and encapsidation course infection. Furthermore, by measuring for collection bacteriophages varying...
The particle aggregation is found to be size sensitive for systems with either a short-ranged or long-ranged attraction introduced by the binary solvent fluctuation. This effect utilized purify particles size.
Penetration of the viral genome into a host cell nucleus is critical for initiation replication most DNA viruses and few RNA viruses. For herpesviruses, ejection occurs when capsid docks at nuclear pore complex (NPC) basket with correct orientation unique portal vertex. It has been shown that vertex-specific component (CVSC) proteins, which are located twelve vertices human herpes simplex virus type 1 (HSV-1) capsid, interact nucleoporins (Nups) NPCs. However, it remained unclear whether...
The physical properties of multicomponent anisotropic colloidal dispersions are still far from being fully understood. This is mainly due to the fact that dealing with nonspherical particles and highly directional interactions is, both experimental theoretical points view, a complicated task. In fact, experiments scarce, we lack model allow us simultaneously simplify capture complexity such systems. this contribution, report on an study hydrodynamic correlations long-time dynamics in...
Structural details of a genome packaged in viral capsid are essential for understanding how the structural arrangement controls its release dynamics during infection, which critically affects replication. We previously found temperature-induced, solid-like to fluid-like mechanical transition λ-genome that leads rapid DNA ejection. However, an origin this was lacking. Here, we use small-angle neutron scattering (SANS) reveal form factor dsDNA phage λ by contrast matching signal from with...
Conformational changes and stability of interacting double-stranded DNA chains under high hydrostatic pressure in biological systems are striking topics importance to study several biomolecular phenomena. For example, unravel the physiological conditions at which life might occur ensure right functionality biochemical processes into cell extreme thermodynamic conditions. Furthermore, such could shed light on physicochemical properties confinement how, through different mechanisms, a virus...