A5022667896- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Mycobacterium research and diagnosis
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Cancer Research and Treatments
- vaccines and immunoinformatics approaches
- Tuberculosis Research and Epidemiology
- Phagocytosis and Immune Regulation
- Renal Transplantation Outcomes and Treatments
- Immune responses and vaccinations
- Hepatitis B Virus Studies
- Glioma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Urinary Tract Infections Management
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
University of Nottingham
2014-2024
BerGenBio (Norway)
2020
Nottingham University Hospitals NHS Trust
2017
Brain Tumour Research
2014-2016
Nottingham City Hospital
2007-2013
Memorial Sloan Kettering Cancer Center
2007
Moffitt Cancer Center
2007
St James's University Hospital
1995-2004
Cancer Research UK
2002-2004
Duke Medical Center
2001-2004
We compare five monoclonal antibodies ( B73 .1, 3G8 , Leu- 11a 11b and VEP13 ) that react with natural killer (NK) cells polymorphonuclear (PMN). show all of these are directed against inhibit the functional properties receptor for Fc portion IgG (FcR). Modulation FcR on NK after reaction immune complexes induces disappearance antigen(s) recognized by each antibodies. Conversely, block binding IgG-sensitized erythrocytes to PMN their ability mediate cytotoxicity antibody-sensitized tumor...
Abstract Introduction IL-17 plays an important role in autoimmunity, promoting inflammation and invasion multiple sclerosis, rheumatoid arthritis type I diabetes. The of cancer is unclear, however, as there are few studies examining protein expression cancer. We therefore examined human breast modelled its potential biological significance vitro . Methods Immunohistochemistry was used to determine cancers. Matrigel assays were employed examine the effect on cell by a panel lines. matrix...
SUMMARY Intravesical immunotherapy for carcinoma in situ of the bladder is arguably most effective form tumour described to date. Following repeated instillations BCG organisms into bladder, large quantities cytokines are detected patients’ urine. This study concerns production IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and soluble ICAM-1 (sICAM-1) throughout six weekly which comprise a therapeutic course. Sequential induced secretion TNF-α,...
// Marka R. Crittenden 1, 2 , Jason Baird 1 David Friedman Talicia Savage Lauren Uhde Alejandro Alice Benjamin Cottam Kristina Young Pippa Newell 3 Cynthia Nguyen Shelly Bambina Gwen Kramer Emmanuel Akporiaye Anna Malecka 4 Andrew Jackson Michael J. Gough Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical OR, USA The Oregon Clinic, Hepatobiliary and Pancreatic Program, Host-Tumour Interactions Group, Division of Stem Cells, University Nottingham,...
Interleukin-18 (IL-18), a cytokine that promotes Th1 responses, is processed to the active mature protein by caspase-1. The effects of Helicobacter pylori infection on gastric IL-18 and caspase-1 were examined. In antral mucosa, mRNA expression was greater (P < .01) in H. pylori—positive (n = 40) than pylori—negative patients 29) with normal mucosa. Inactive precursor (24 kDa) (18 present biopsy specimens from uninfected infected subjects. corpus 16-kDa protein, corresponding inactive IL-18,...
Regulation of alternative splicing is a new therapeutic approach in cancer. The programmed cell death receptor 1 (PD-1) an immunoinhibitory expressed on immune cells that binds to its ligands, PD-L1 and PD-L2 by cancer forming dominant checkpoint pathway the tumour microenvironment. Targeting this using blocking antibodies (nivolumab pembrolizumab) mainstay anti-cancer immunotherapies, restoring function exhausted T cells. PD-1 alternatively spliced form isoforms are either transmembrane...
No AccessJournal of UrologyInvestigative Urology1 Aug 1995Interleukin-6 Production by Bladder Tumors is Upregulated BCG Immunotherapy K.* Esuvaranathan, A.B. Alexandroff, M. McIntyre, A.M. Jackson, S. Prescott, G.D. Chisholm, and K. James EsuvaranathanK.* Esuvaranathan , AlexandroffA.B. Alexandroff McIntyreM. McIntyre JacksonA.M. Jackson PrescottS. Prescott ChisholmG.D. Chisholm JamesK. View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67113-1AboutFull TextPDF ToolsAdd to...
Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause systemic immunosuppression. We demonstrate that radiation therapy tumors leads to decline myeloid cell numbers the blood and decrease spleen size. The frequency cells does not level seen tumor-free mice: we metastatic disease can prevent from returning baseline, tumor recurrence residual correlates with re-expansion lineage cells. Radiation results increased proliferation T while responses foreign...
An accumulating body of evidence demonstrates that radiation therapy can generate adaptive immune responses contribute to tumor control. However, in the absence additional therapy, response is insufficient prevent recurrence or affect distant disease. It has been shown multiple models tumor-infiltrating myeloid cells exhibit alternative activation phenotypes and are able suppress responses, recent data suggests tumors treated with cytotoxic limits We hypothesized inhibit after through...
Unlike other helper T cells, the costimulatory ligands responsible for regulatory type 1 (Tr1) cell differentiation remain undefined. Understanding molecular interactions driving peripheral Tr1 is important because Tr1s potently regulate immune responses by IL-10 production. In this study, we show that costimulation of human naive CD4(+) cells through CD97/CD55 interaction drives activation, expansion, and function. activation expansion was equipotent with CD55 or CD28 costimulation;...
Gap junctions are specialized membrane structures that form channels between adjacent cells allowing cell communication. and specifically Connexin 43 (Cx43) down-regulated in cancer; however, there contrasting reports on how this effects breast cancer patient survival. This paper is the first large-scale tissue microarray analysis of Cx43 expression patients with an associated clinical long-term follow-up. Using a validated TMA 1118 primary cancers, coupled to comprehensive database...
Introduction Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification CD8 T-cells alone cannot determine antigenic experience, as not all infiltrating recognize antigens. Activated tumour-specific tissue resident memory (T RM ) can be defined by co-express CD103, CD39 and CD8. We investigated hypothesis that abundance localization T provides a higher-resolution route to patient stratification. Methods A...
Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to presence of LVI angiogenesis. This study investigates role macrophage-derived, caspase-1-dependent interleukin-1beta (IL-1β) vitro model LVI. IL-1β significantly augmented adhesion transmigration breast cancer cell lines MCF7 MDA-MB-231 across endothelial barriers. showed a higher percentage cells than following...
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity therefore new strategies are urgently needed. Dendritic cells the power to create anti-tumor immune responses. The greater potency of circulating dendritic (DC) over laboratory-generated monocyte-derived DC makes them exciting immunotherapeutic candidates. To determine status GBM patients we initially investigated frequency function subsets. Furthermore, tested therapeutic potential inhibiting p38...
Dysfunctional dendritic cells (DC) are common in cancer patients; however, the underlying molecular targets poorly understood. Nevertheless, adoptive-transfer and situ vaccination protocols continue, largely without addressing immune-suppression. Understanding tumour-mediated DC suppression would assist rational design of next generation immunotherapy. This study used a tumour-lysate loaded model adoptive immunotherapy also necrotic many tumours. Patient-derived healthy-donor...
AIMS--To determine the expression of intercellular adhesion molecule 1 and 2 (ICAM 2) in transitional cell carcinoma cells before after immunotherapy with Calmette-Guérin bacillus (BCG). METHODS--Frozen sections from 22 untreated bladder carcinomas were immunohistochemically examined monoclonal antibodies to ICAM 2. Urinary cytospin slides made for six patients each clinical instillations which constitute a therapeutic course. These also stained leucocyte function associated antigen (LFA 1)....