A5005463138- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Ion channel regulation and function
- Cardiovascular Issues in Pregnancy
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Heart Failure Treatment and Management
- Pregnancy and preeclampsia studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced Causal Inference Techniques
- Infective Endocarditis Diagnosis and Management
- Hepatitis B Virus Studies
- Heart Rate Variability and Autonomic Control
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular and Diving-Related Complications
- Streptococcal Infections and Treatments
Instituto de Investigación Sanitaria del Principado de Asturias
2017-2025
Central University Hospital of Asturias
2015-2024
Gobierno del Principado de Asturias
2024
University of Michigan
2021
The Arrhythmia Institute
2020
Universidad Complutense de Madrid
2018
Software (Spain)
2018
National University of Distance Education
2018
Universidad Politécnica de Madrid
2018
University of Miami Hospital
2015
Treatment with β-blockers fails to decrease portal pressure in nearly 40% of cirrhotic patients. Recent studies have suggested that treatment spironolactone reduces and flow the variceal systems. This trial was designed assess if nadolol plus is more effective than alone prevent first bleeding. One hundred patients medium large varices who had never bled were without ascites included a prospective, randomized, multicenter, double-blind, placebo-controlled trial. The randomized into 2 groups:...
Fragmentation and delayed potentials in the QRS signal of patients have been postulated as risk markers for Sudden Cardiac Death (SCD). The analysis high-frequency spectral content may be useful quantification.Forty-two consecutive with prior history SCD or malignant arrhythmias (patients) where compared 120 healthy individuals (controls). complexes were extracted a modified Pan-Tompkins algorithm processed Continuous Wavelet Transform to analyze (85-130 Hz).Overall, power was higher...
Sensitivity to flecainide testing results in suboptimal findings patients with Brugada syndrome (BrS), leading safety concerns. Because cardiac syncope effectively predicts outcomes BrS, we aimed explore its predictive value a large cohort of negative and positive responders (NR PR) standard testing.We analysed the data 251 consecutive patients, 177 NR vs. 74 PR, testing, performed according recommendations. Cardiac was defined as presenting without prodromal symptoms absence any specific...
Propensity Score Matching (PSM) is a useful method to reduce the impact of Treatment-Selection Bias in estimation causal effects observational studies. After matching, PSM significantly reduces sample under investigation, which may lead other possible biases (due overfitting, excess covariation or reduced number observations). In this sense, we wanted analyze behavior compared with widely used methods deal non-comparable groups, such as Multivariate Regression Model (MRM). Monte Carlo...
Tachycardia mediated by septal accessory pathways (AP) and atypical atrioventricular nodal re-entry (AVNRT) require careful electrophysiologic evaluation for differential diagnosis. We aim to describe the behaviour of local ventriculo-atrial (VA) intervals which predicts tachycardia mechanism.The VA at para-Hisian septum were measured under three different situations: (i) tachycardia; (ii) sustained entrainment from right ventricular apex (RVA); (iii) continuous pacing RVA during sinus...
Abstract Background and objectives Early failure of Biotronik Linox Smart leads (Biotronik, Berlin, Germany) has been reported in numerous recent publications. The aim this study was to assess the performance lead compared with that two other contemporary leads. Methods We conducted an ambispective all consecutive first implantations defibrillator carried out our center: Endotak (model 148, 158, Boston Scientific, Marlborough, MA, USA) (n = 173), Sprint Quattro 6644, 6947, Medtronic, Dublin,...
(1) Background: The clinical management of Brugada Syndrome (BrS) remains suboptimal. (2) Objective: To explore the role standard electrocardiogram (ECG) spectral analysis in diagnosis and risk stratification. (3) Methods: We analyzed 337 patients-43 with a spontaneous type I ECG pattern (Spont-BrS), 112 drug induced (Induct-BrS), 182 negative response to challenge (negative responders (NR)). ECGs were processed using wavelet transform (high frequency: 85 130 Hz). (4) Results: power...
Studies of cardiovascular function in pregnancy have shown inconsistent and, some cases, contradictory results, particularly regarding cardiac output. While studies report preeclampsia associated with high output, other suggest that should be further subdivided into women or low This study was conducted to examine the NT-proBNP levels preeclampsia, intrauterine growth restriction, and hypertensive pregnancies without preeclampsia. We also examined N-terminal pro-B natriuretic peptide...
Background Activation during onset of atrial fibrillation is poorly understood. We aimed at developing a panoramic optical mapping system for the atria and test hypothesis that sequential rotors underlie acceleration onset. Methods Results Five sheep hearts were Langendorff perfused in presence 0.25 µmol/L carbachol. Novel recorded activations simultaneously from entire left right endocardial surfaces. Twenty sustained (>40 s) episodes induced by train premature stimuli protocol. Movies...
Abstract Introduction Our aim was to characterize a stepwise approach in cavotricuspid isthmus ablation for typical atrial flutter prospective, noncrossover randomized study. Methods One hundred and fifty patients referred (CTI)‐dependent were undergo an with 8‐mm‐tip catheter (group 1), 3.5‐mm open irrigation‐tip 2), irrigation porous‐tip 3). A performed, changing the site from medial septal aspects of CTI, case it not effective without crossover between catheters. Results CTI block...
Background: there is increasing interest for computing corrected QT intervals in patients with prolonged depolarization. We aimed to analyze the effect of QRS and diagnostic accuracy frequency-correction. Methods Results: 28 admitted self-expanding aortic valve implantation, sequential pacing was performed AAI mode two different phases: before immediately after release prosthesis. evaluated Bazett, Fridericia, Framingham Hodges formulas reference at 60 bpm (QTc/deviation). The widening main...
Sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are new glucose-lowering drugs (GLDs) with demonstrated cardiovascular benefits in patients heart disease and type-2 diabetes mellitus (T2DM). However, their safety efficacy when prescribed at hospital discharge unexplored. This prospective, observational, longitudinal cohort study included 104 consecutive T2DM discharged from the cardiology department between April 2018 February 2019. Patients were classified based on SGLT-2...