A5001009798- Computational Drug Discovery Methods
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- Cassava research and cyanide
- Neurological disorders and treatments
- Metal and Thin Film Mechanics
- Urban Stormwater Management Solutions
- Estrogen and related hormone effects
- Supercapacitor Materials and Fabrication
- Drug-Induced Hepatotoxicity and Protection
- Voice and Speech Disorders
- Psidium guajava Extracts and Applications
- Electrospun Nanofibers in Biomedical Applications
- Natural Antidiabetic Agents Studies
- Retinal Development and Disorders
- Magnesium Alloys: Properties and Applications
- Corrosion Behavior and Inhibition
- Flood Risk Assessment and Management
- Hibiscus Plant Research Studies
- Nanoporous metals and alloys
- Effects and risks of endocrine disrupting chemicals
- Polymer Surface Interaction Studies
- Immunotherapy and Immune Responses
- Phytochemicals and Antioxidant Activities
- Urban Heat Island Mitigation
Southwest Jiaotong University
2020-2025
COMSATS University Islamabad
2020-2022
Abbottabad University of Science and Technology
2021-2022
Abbott (United Kingdom)
2020
Sodium carboxymethylcellulose (CMC) is a biocompatible and biodegradable derivative of cellulose, making it promising material for biomedical applications. However, its poor stability in aqueous environments has significantly limited use long-term devices. Here, we present the first time simple controllable method to enhance wet CMC coatings by cross-linking polydopamine (PDA) self-polymerization PDA widespread applications A series CMC/PDA were fabricated on initial layers using dip coating...
is also known as "Miracle tree", due to its multiple uses and adaptability. Because of nutritive pharmacological values, it widely cultivated across the world.
Natural antioxidants possess health beneficial properties and are being substantially used in foods, cosmetics pharmaceutical products. Polyphenolics content, antioxidant activity HepG2 liver cancer cells' inhibition potential were determined compared the fruit of apricot cultivars collected from lower Himalayan region Pakistan using standard analytical procedures. Comparatively, AP3 cultivar had highest levels total phenolics flavonoids contents (220.5 ± 15.9 mgGAE/100 g 382.0 18.0 mgQE/100...
Amygdalin a naturally occurring compound, predominantly in the bitter kernels of apricot, almond, apple and other members Rosaceae family. Though, amygdalin is used as an alternative therapy to treat various types cancer but its role pathways has rarely been explored yet. Therefore, present study was intended with aim investigate alleged anti-cancerous effects specifically on PI3K–AKT–mTOR Ras human body. Computational modelling simulation techniques were assess effect PI3K-AKT-mTOR using...
TiCu coatings with controlled copper release and nano-porous structures were fabricated as biocompatible, blood-contacting interfaces through a two-step process. Initially, 58 % Cu created using HiPIMS/DC magnetron co-sputtering, followed by immersion in dilute HF solution for varying durations to achieve dealloying. The presence of Ti elements the as-deposited facilitated their dissolution upon exposure solution, resulting formation nanopores increased nano-roughness. Dealloying treatment...
The strong association between POPs and breast cancer in humans has been suggested various epidemiological studies. However, the interaction of with ERα protein cancer, identification natural synthetic compounds to inhibit this interaction, is mysterious yet. Consequently, present study aimed explore using molecular operating environment (MOE) tool identify through a cluster-based approach. To validate whether our approach could distinguish active inactive compounds, virtual screen (VS) was...
The main objective of this study was to assess the quality and quantity roof-harvested rainwater overcome water shortage problem in area. We also aimed find health hazards associated with For purpose, samples were collected from five sites analyzed using standard methods World Health Organization American Public Association a laboratory. analysis showed that all physicochemical parameters within permissible limits WHO’s guidelines except pH, turbidity, some trace metals such as iron (Fe)...
Achromatopsia (ACHM) is a genetically heterogeneous visual disorder, also known as rod monochromatism, in which human get affected due to cone cells. Mutation five genes viz. CNGA3, CNGB3, GNAT2, PDE6C, and PDE6H have been reported ACHM. These encode essential constitutes of the cone-specific photo transduction cascade. Present study was focused on CNGB3 gene that accounts 40%-50% mutations all ACHM cases. A new approach for analyzing drug-drug interactions based modularity adopted. This...
Inorganic pollutant, specifically heavy metals' contamination, is a significant matter of concern and one the key contributors in various health disorders including cancer. However, interaction metals (HMs) with lung cancer has rarely been explored yet. Therefore, present study was intended aim to identify interactions HMs target protein "epidermal growth factor receptor (EGFR)" explore potential drug candidates, which could inhibit active site EGFR against HM exposure. The molecular...
Abstract Novel coronavirus (2019-nCoV), since its emergence from Wuhan China in December 31, 2019 is still uncontrolled and has raised attention around the globe. According to World health organization, up March 20, 2020, globally 209,839 confirmed cases of COVID-19 have been reported along with 8778 deaths. 2019-nCoV likely be a recombinant different coronaviruses such as SARS CoV MERS CoV. Recent developments revealed that glycosylated spike (S) protein 2019-nCov contributing significantly...