A5084776949- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Chromatin Remodeling and Cancer
- Plant Disease Resistance and Genetics
- RNA Research and Splicing
- RNA modifications and cancer
- Plant Molecular Biology Research
- Biofuel production and bioconversion
- Early Childhood Education and Development
- Peptidase Inhibition and Analysis
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Cancer Mechanisms and Therapy
- Mechanisms of cancer metastasis
- Genetic Mapping and Diversity in Plants and Animals
- Nuclear Structure and Function
- Motivation and Self-Concept in Sports
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Child and Adolescent Psychosocial and Emotional Development
- Protein Degradation and Inhibitors
- Cerebrovascular and genetic disorders
- Cancer Genomics and Diagnostics
Universidad de Sevilla
2017-2024
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2017-2024
Universidad Pablo de Olavide
2017-2024
Consejo Superior de Investigaciones Científicas
2017-2024
Universidad de Granada
2022
SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014, an inhibitor ATPase activity complexes. We find that is required to maintain accessibility and nucleosome occupancy for most enhancers but not promoters. needed expression with low medium levels have promoters (1) accessibility, (2) active histone marks, (3) high H3K4me1/H3K4me3 ratio, (4) nucleosomal phasing, (5) enrichment...
Tudor domain containing protein 9 (TDRD9) is a RNA helicase normally expressed in the germline, where it involved biosynthesis of PIWI-interacting RNAs (piRNAs). Here, we show that TDRD9 highly subset non-small cell lung carcinomas and derived lines by hypomethylation its CpG island. Furthermore, expression associated with poor prognosis adenocarcinoma. We find downregulation TDRD9-positive causes decrease proliferation, S-phase cycle arrest, apoptosis. Transcriptomic analysis demonstrated...
A complex interplay between chromatin and topological machineries is critical for genome architecture function. However, little known about these reciprocal interactions, even cohesin, despite its multiple roles in DNA metabolism. We have used genome-wide analyses to address how cohesins structure impact each other yeast. Cohesin inactivation scc1-73 mutants during the S G2 phases causes specific changes that preferentially take place at promoters; include a significant increase occupancy of...
Social interaction skills are related to successful academic performance and mental health. One of the key elements socio-emotional competence is self-regulation. The main aim this study was analyze effect a self-regulation program at primary school on social interactions neurotypical children with special educational needs, from teachers' parents' perspectives. A pre-post conducted. (n = 107) followed 10 sessions, each one 50 min, for ten weeks, between January April 2021. To assess changes...
Abstract Bromodomain and extra-terminal (BET) proteins are relevant chromatin adaptors involved in the transcriptional control of thousands genes. Two tandem N-terminal bromodomains essential for attachment through acetyl-histone recognition. Recently, BET members BRD2 BRD4 were found to interact with SARS-CoV-2 envelope (E) protein, raising question whether interaction constitutes a virus hijacking mechanism transcription alteration host cell. To shed light on this question, we have...
Abstract The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination migration, circulating generation, cancer stem cells, chemoresistance, metastasis formation. To identify chromatin epigenetic factors possibly involved in the process of EMT, we compare levels expression genes a transformed human breast epithelial line (HMEC-RAS) versus stable clone same expressing EMT master regulator ZEB1 (HMEC-RAS-ZEB1). One strongly induced...
High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and proliferation. The protein HMG20A is predicted by the AlphaFold2 software to contain three distinct structural elements, which we have functionally characterized: i) an amino-terminal, intrinsically disordered domain transactivation activity; ii) HMG box higher binding affinity for double-stranded, four-way-junction DNA than linear DNA; iii) a long coiled-coil domain....
The accuracy of most DNA processes depends on chromatin integrity and dynamics. Our analyses in the yeast