A5093932845- Chemical Synthesis and Analysis
- Photochromic and Fluorescence Chemistry
- Estrogen and related hormone effects
- Protein Degradation and Inhibitors
- RNA and protein synthesis mechanisms
- Developmental Biology and Gene Regulation
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
Skidmore College
2024
Harvard University
2024
Dana-Farber Cancer Institute
2024
We report the design conception, chemical synthesis, and microbiological evaluation of bridged macrobicyclic antibiotic cresomycin (CRM), which overcomes evolutionarily diverse forms antimicrobial resistance that render modern antibiotics ineffective. CRM exhibits in vitro vivo efficacy against both Gram-positive Gram-negative bacteria, including multidrug-resistant strains
Abstract Medulloblastoma is one of the most common malignant brain tumors children, and 30% medulloblastomas are driven by gain-of-function genetic lesions in Sonic Hedgehog (SHH) signaling pathway. EYA1, a haloacid dehalogenase phosphatase transcription factor, critical for tumorigenesis proliferation SHH medulloblastoma (SHH-MB). Benzarone benzbromarone have been identified as allosteric inhibitors EYA proteins. Using benzarone point departure, we developed panel 35 derivatives tested them...
<div>Abstract<p>Medulloblastoma is one of the most common malignant brain tumors children, and 30% medulloblastomas are driven by gain-of-function genetic lesions in Sonic Hedgehog (SHH) signaling pathway. EYA1, a haloacid dehalogenase phosphatase transcription factor, critical for tumorigenesis proliferation SHH medulloblastoma (SHH-MB). Benzarone benzbromarone have been identified as allosteric inhibitors EYA proteins. Using benzarone point departure, we developed panel 35...
<p>Supplemental Methods and Figure Legends</p>
<p>Supplemental Figures 1-8</p>
<p>Supplemental Table 3</p>
<p>Supplemental Table 1</p>
<p>Supplemental Table 5</p>
<p>Supplemental Table 2</p>
<p>Supplemental Table 6</p>
<p>Supplemental Table 4</p>
<p>Supplemental Table 6</p>
<div>Abstract<p>Medulloblastoma is one of the most common malignant brain tumors children, and 30% medulloblastomas are driven by gain-of-function genetic lesions in Sonic Hedgehog (SHH) signaling pathway. EYA1, a haloacid dehalogenase phosphatase transcription factor, critical for tumorigenesis proliferation SHH medulloblastoma (SHH-MB). Benzarone benzbromarone have been identified as allosteric inhibitors EYA proteins. Using benzarone point departure, we developed panel 35...
<p>Supplemental Figures 1-8</p>
<p>Supplemental Methods and Figure Legends</p>
<p>Supplemental Table 5</p>
<p>Supplemental Table 2</p>
<p>Supplemental Table 1</p>
<p>Supplemental Table 4</p>
<p>Supplemental Table 3</p>