A5034568071- Hemoglobinopathies and Related Disorders
- Biofuel production and bioconversion
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Microbial Metabolic Engineering and Bioproduction
- Iron Metabolism and Disorders
- Enzyme-mediated dye degradation
- Virology and Viral Diseases
- Catalysis for Biomass Conversion
- Bacterial biofilms and quorum sensing
- Studies on Chitinases and Chitosanases
- Insect Pest Control Strategies
- Bacterial Identification and Susceptibility Testing
- Prenatal Screening and Diagnostics
- Insect Resistance and Genetics
- Fungal Biology and Applications
- Microbial Metabolism and Applications
- Reproductive Health and Technologies
- Transgenic Plants and Applications
- Nanocomposite Films for Food Packaging
- Microbial bioremediation and biosurfactants
- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
King Abdulaziz City for Science and Technology
2022-2025
Imam Abdulrahman Bin Faisal University
2018-2022
King Saud University
2020
Saudi Center for Disease Prevention and Control
2020
Abstract The prevalence of consanguineous marriage and genetic disorders are high in Saudi Arabia. There were records on the practices Saudis toward prenatal diagnosis (PND) termination pregnancy (TOP), however sample sizes small. This study has targeted Arabian community family history to determine PND TOP. cross-sectional survey was conducted among ( n = 2761) their reproductive-decision making. Regression analysis identify association limiting factors, relative merits outcomes. Total 2507...
Endophytic fungi serve as a reservoir for important secondary metabolites. The current study focused on the antibacterial properties of endophytic isolated from Artemisia sieberi. Initially, six were and purified stem A. identified by morphological characteristics, well molecular identification using 18S rRNA gene sequencing method. All isolates subjected to preliminary screening their activity against nine pathogenic bacteria disk-diffusion Crude extracts most active isolate obtained ethyl...
Forty-six promising chitinolytic isolates were recovered during a screening for bacteria in the environment of Saudi Arabia. The top three belonged to genus Streptomyces. Streptomyces variabilis Am1 was able excrete highest amount chitinases, reaching maximum at 84 h with 0.5% yeast extract and nitrogen source 2% galactose as carbon source. Purification chitinase by DEAE-Cellulose Sephadex G75 improved specific activity 18.6-fold recovery 23.8% showed mass 56 kDa. optimal catalysis purified...
Methicillin-resistant Staphylococcus aureus (MRSA) surveillance in regions with mass gatherings presents unique challenges for public health systems. Saudi Arabia, hosting millions of pilgrims annually, provides a distinctive setting studying how human mobility shapes bacterial populations, yet comprehensive genomic data from this region remains limited. Here, we present an integrated analysis S. isolates collected across seven Arabian regions, combining whole-genome sequencing extensive...
Laccase production was evaluated in 108 fungal isolates recovered from the eastern coast of Saudi Arabia, a critical element environmental biodegradation and biotransformation. The most active isolate identified as Curvularia lunata MLK46 (GenBank accession no. PQ100161). It exhibited maximal productivity at pH 6.5, 30 °C, incubation for 5 d, with 1% sodium nitrate galactose preferred nitrogen carbon sources, respectively. Productivity enhanced by NaCl, CuSO4, FeCl3 supplementation, maximum...
Extracellular production of fungal lipases especially the obtained from Aspergilli has gained immense interest in recent years due to its diverse biotechnological applications. In this study, we focused on determining fermentation parameters required for optimal lipase production.A total 256 isolates were oil seeds. From each genus, one isolate was selected evaluate using phenol red and tributyrin plate assays. Lipase activity estimated spectrophotometric pNPP hydrolysis assay. The highest...
Lignocellulose, the main component of a plant cell wall, is potential renewable bioenergy source. It composed cellulose, hemicellulose, and lignin structures. Cellulose linear polysaccharide that hydrolyzed chemically or enzymatically by cellulase. The addition lignocellulosic biomass, such as wheat bran coffee pulp, into fermentation culture, induces production cellulases. accounts for 20% enzyme market worldwide, demonstrating benefits in diverse applications, especially bioethanol biogas...
Detection of β-thalassemia trait or carriers (β-TT) depends significantly on an increase in Hemoglobin A2 (HbA2) levels, which is found at low levels (<3%) normal healthy individuals and elevated (≥3.5%) β-TT individuals. The study was designed to evaluate the reliability diagnostic parameter HbA2 differentiation non-β-TT Saudis.The widely used high performance liquid chromatography (Variant II Bio-Rad) measure blood. Sanger sequencing screen variation globin genes (HBB, HBD, HBA1, HBA2)....
Objective . Methicillin-resistant Staphylococcus aureus (MRSA) is one of the main causative agents nosocomial infections that has posed a major threat to those with compromised immune systems such as nursing home residents. The aim this study was determine rates MRSA strains and types Staphylococcal Cassette Chromosome mec (SCCmec )in homes in Saudi Arabia. Methods A total 188 nasal swabs were collected from residents staff two Riyadh, All isolates tested for antimicrobial susceptibility...
Autism is a complex disease with genetic predisposition factors. Real factors for treatment and early diagnosis are yet to be defined. This study integrated transcriptome exome genotyping identifying functional variants associated autism spectrum disorder their impact on gene expression find significant variations. More than 1800 patients were screened, 70 (47 male/23 female) an average age of 7.56 ± 3.68 years fulfilled the DSM-5 criteria autism. Analysis revealed 682 SNPs 589 genes...
The two-spotted spider mite (TSSM) Tetranychus urticae, is regarded as one of the most dangerous pests responsible for great losses in agricultural crops. It a persistent pest Saudi Arabia, especially greenhouses where T. urticae primarily controlled by chemical pesticides. main problem mites its high resistance to pesticides and fertility rate. In long term, cause health problems economic losses, so it was necessary search safe alternative method human environment. One these methods...
Abnormality in HBB results an inherited recessive blood disorder, which can be caused by variants at the transcriptional or translational level affecting stability and production of chain. The severity disease relies on variant's characteristics. This study aimed to identify common β-globin population Eastern Province, has highest prevalence diseases Saudi Arabia.Direct sequence gene, alpha-globin HBA1 HBA2 genes was performed a total 545 samples (transfusion-dependent: 215, 106 men 109...
Abstract 2,6-Dichlorophenol (2,6-DCP) is an aromatic compound with industrial importance in making insecticides, herbicides, and other organic compounds. However, it poses serious health ecological problems. Microbial degradation of 2,6-DCP has been widely applied due to its effectiveness eco-friendly characteristics. In this study, Trichoderma longibraciatum was isolated from soil sample Dammam, Saudi Arabia using the enrichment method mineral salt's medium (MSM) amended 2,6-DCP....