A5056803862- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Medical Education and Admissions
- Healthcare professionals’ stress and burnout
- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Cardiac, Anesthesia and Surgical Outcomes
- Stoma care and complications
- Neuroscience, Education and Cognitive Function
- Aortic aneurysm repair treatments
- Thyroid Cancer Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Genital Health and Disease
- Cancer Diagnosis and Treatment
- Innovations in Medical Education
- Mental Health Research Topics
- Diversity and Career in Medicine
University of Oxford
2018-2023
John Radcliffe Hospital
2019
Abstract Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used mouse model of propionic acidaemia (PA) to study how disturbances propionate metabolism result in histone modifications changes gene expression that affect cardiac function. Plasma surrogates were raised PA mice, but female hearts manifested more profound acyl-CoAs, propionylation acetylation, transcription. These resulted moderate diastolic dysfunction with Ca...
Conduits used in coronary artery bypass grafting may have significant impact on outcomes, but evidence is mixed and there large variation practice. This study provides insights into the opinions of UK surgeons conduit use their decision-making processes.A questionnaire was created using Ottawa Decision Support Framework to elicit importance that placed bilateral internal mammary grafting, skeletonization, total arterial revascularization sequential anastomoses a scale 1-10. Scores ≥8 were...
Propionic acidaemia (PA) is an autosomal recessive disorder characterised by malfunctional mitochondrial propionyl-CoA carboxylase. Consequences of this inborn error metabolism (IEM) defective catabolism propiogenic substrates (branched-chain amino acids, odd-number fatty etc.) leading to accumulation propionyl CoA and its derivatives. Accumulation propionate derivatives in the cytoplasm plasma leads intra- extracellular metabolic acidosis. The clinical manifestation severe; arrhythmia...
Follicular thyroid carcinoma most commonly metastasises to the lungs, liver, and non-cranial bones. Where skin metastases have occurred, this has been in context of diffuse metastatic disease, occur scalp. Cutaneous deposits neck described papillary carcinoma, but we believe be first description cancer recurrence presenting as cutaneous follicular carcinoma. A pigmented lesion a patient with history could represent metastasis should treated suspicion.