A5056565420- Ocular Oncology and Treatments
- Cell Adhesion Molecules Research
- Prostate Cancer Treatment and Research
- Retinal Development and Disorders
- Nanoplatforms for cancer theranostics
- Hippo pathway signaling and YAP/TAZ
- Urologic and reproductive health conditions
- Immunotherapy and Immune Responses
- Microtubule and mitosis dynamics
- Glaucoma and retinal disorders
- Endodontics and Root Canal Treatments
- Cardiovascular Conditions and Treatments
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Dental Radiography and Imaging
- Advanced Fluorescence Microscopy Techniques
University of California, San Diego
2021-2023
Universidade Federal do Paraná
2016-2018
Uveal melanoma is the most common eye cancer in adults. Approximately 50% of patients with uveal develop metastatic (mUM) liver, even after successful treatment primary lesions. mUM refractory to current chemo- and immune-therapies, die within a year. characterized by gain-of-function mutations
Foram estudados 30 corações de cães adultos, buscando-se evidenciar a ocorrência das pontes miocárdio. Os foram fixados em solução formol 10% tamponada e seguida dissecados. Pontes miocárdio identificadas 76,67% dos corações. No total, 32 observadas, nas quais frequência sobre o ramo direito (12,50%) diferiu do esquerdo (87,50%) da artéria coronária. A largura média foi 6,092mm. análise histomorfológica revelou redução luz arterial com mediana 53,4% quando comparada ao segmento proximal à ponte
<p>Supplementary Figure S4. MEKi/FAKi combination reduces B2905 syngeneic cells growth in allograft tumor models.</p>
<p>Supplementary figure S1. Synthetic lethality of FAK and ERK/MAPK pathway inhibition.</p>
<p>Supplementary figure S2. Isobologram analysis.</p>
<div>AbstractPurpose:<p>Uveal melanoma is the most common eye cancer in adults. Approximately 50% of patients with uveal develop metastatic (mUM) liver, even after successful treatment primary lesions. mUM refractory to current chemo- and immune-therapies, die within a year. Uveal characterized by gain-of-function mutations <i>GNAQ</i>/<i>GNA11</i>, encoding Gαq proteins. We have recently shown that Gαq–oncogenic signaling circuitry involves noncanonical...
<div>AbstractPurpose:<p>Uveal melanoma is the most common eye cancer in adults. Approximately 50% of patients with uveal develop metastatic (mUM) liver, even after successful treatment primary lesions. mUM refractory to current chemo- and immune-therapies, die within a year. Uveal characterized by gain-of-function mutations <i>GNAQ</i>/<i>GNA11</i>, encoding Gαq proteins. We have recently shown that Gαq–oncogenic signaling circuitry involves noncanonical...
<p>Supplementary figure 3. MEKi/FAKi combination reduces UM cells growth in xenograft tumor models with limited toxicity.</p>
<p>Supplementary Figure S4. MEKi/FAKi combination reduces B2905 syngeneic cells growth in allograft tumor models.</p>
<p>Supplementary figure 3. MEKi/FAKi combination reduces UM cells growth in xenograft tumor models with limited toxicity.</p>
<p>Supplementary figure S1. Synthetic lethality of FAK and ERK/MAPK pathway inhibition.</p>
<p>Supplementary figure S2. Isobologram analysis.</p>
Industry data for pet products has revealed that most Brazilian families have pets in their homes and humans give a large amount of attention to pets. Oral diseases are among the quickly perceived treated pathologies; common these is periodontal disease, which can affect pulp requires endodontic treatment. Recently, evelopment superelastic nickel-titanium alloys revolutionized therapy, as been used develop novel rotary instruments. The goal this study was evaluate efficiency such instruments...