Toll-like receptors (TLRs) can be expressed by tumor cells, and each TLR exhibits different biological functions. Evidences showed the activation of some certain TLRs could promote progression. One which TLR4 has been found to hepatocellular carcinoma (HCC) cells proliferation, but detailed mechanism is still unknown. In present study, we verified that was functionally on HCC agonist lipopolysaccharide (LPS) stimulate proliferation clone formation cells. Most importantly, a COX-2/PGE2/STAT3...

This paper proposes a new direct thrust control algorithm combining dynamic candidate vector set and multilevel hysteresis controller. method can effectively reduce the primary flux electromagnetic fluctuations by adjusti ng parameters of The selecting width level controller is analyzed verified simulation experiment. After appropriate parameters, comparison experiment with combined space modulation (DTC-SVM) shows that steady-state performance two algorithms about approximately same.

In an electromagnetic launch system, the surface of aluminum alloy armature is subjected to high-temperature ablation, leading generation significant metal vapor and initiation high-energy arcs. This damages structure can result in a failure. Enhancing ablation resistance crucial for improving efficiency. this study, model modification was constructed. The impact CoCrNiFeAlx surface-modified material on structural changes during arc elucidated through molecular dynamics simulation. Results...

Liver cancer is one of the most common malignant tumors worldwide. Thioredoxin reductase (TrxR) highly expressed in liver cells. The present study aimed to investigate effect inhibiting TrxR on and better understand underlying molecular immuno-logical mechanisms associated with inhibition. It was demonstrated that targeting inhibited growth induced apoptosis cells, which accompanied by activation mitogen protein kinase pathway. This inhibition dependent production reactive oxygen species...

The half-wavelength AC transmission technology is attracting more and attentions home abroad by its unique economic technological advantages. paper starts describing the history research status of technology, then sums up basic characteristics technology. This carries out a detailed analysis about several key technical issues lines, including artificial line tuning network optimization, power transient stability characteristics, operation maintenance arc suppression, internal over-voltage....

The generation of a very strong peak current in the first period (PCFP) pulse-modulated microwave discharge has been discussed previous studies. In this paper we focus on transition process from pulsed to fully continuous one driven by power source means kinetic model. computational results show that increasing duty cycle or voltage modulation rate (VMR), eventually becomes and PCFP can no longer be observed. process, distributions electric field, electron energy probability function (EEPF)...

Phase autofocus is a key step of translational motion compensation (TMC) in inverse synthetic aperture radar (ISAR). In this paper, an effective phase algorithm for ISAR proposed based on single eigenvector. Samplings multiple range bins are used to construct the covariance matrix and obtain eigenvector corresponding largest eigenvalue. It found that can act as vector autofocus. Compared conventional methods, better focused image especially low SNR case, long there relatively prominent...

Aerospace electromechanical servo system is a typical strongly nonlinear and coupling system, where the friction main factor that impacts performance. As conventional closed loop controller can not meet high performance requirements, an adaptive compensation method based on LuGre model proposed in this paper. For unknown dynamic parameters load characteristics of forming principle analyzed. After that, designed through Lyapunov stability analysis, dual-closed observer constructed to estimate...

There exist serious coupling effects between the ultra high voltage(UHV) double-circuit transmission lines. In spite of elucidating detailedly both static and electromagnetic mechanisms, impacts line transposition mode on induced voltages currents are analyzed via established equivalent circuit model. As a case study which incorporates UHV lines to be built in east China, voltage current along maintenance under different conditions have been calculated through ATP-EMTP. Specifically,...

Sintering-free lightweight aggregates were prepared with high proportions of red mud and a binder material derived from whole solid wastes through rolling granulation at room temperature. The preparation process was optimized by changing the matching size parameters SFLAs. physico-chemical performance, including density, mechanical strength, water absorption, hydration products, heavy metal leaching, microstructure evaluated jointly employing X-ray Fluorescence, Diffraction, Inductively...

The work aims to enhance and modify the armature surface in electromagnetic rail launch systems improve its anti-ablation performance better resist impact ablation effects of high-temperature high-speed arcs during process reliability. TiC particles are widely selected as metal material reinforcements, with advantages such high melting points hardness. In this paper, arc model pure aluminum alloy particle-reinforced aluminum-matrix composite coating–pure were constructed based on molecular...

With the rapid consumer adoption of mobile devices such as tablets and smart phones, tele-traffic has experienced a tremendous growth, making low-power technologies highly desirable for future communication networks. In this paper, we consider an ambient backscatter (AB)-based user cooperation (UC) scheme mmWave wireless-powered networks (WPCNs) with lens antenna arrays. Firstly, formulate optimization problem to maximize minimum rate two users by jointly designing power time allocation....

This paper introduces a small negative pressure wall-climbing robot with the ARM system. It can complete task on surface of vertical, steep. First all, describes basic system structure and mechanical configuration. Secondly, mechanic analyses dynamics modeling to explain principle its operation. Finally, an experiment tests all common functions robot.

(E)-3-(2-Chlorophenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1,2,3,6-tetrahydropyridine-4-yl)phenyl)-2-propylene-1-one (L41) is a novel synthetic cyclin-dependent kinase 1 inhibitor. In this study, we proposed strategy to systematically characterize associated phase I and II metabolites of L41 using rat plasma urine samples. Biological samples were treated with an optimized sample preparation approach involving protein precipitation, liquid–liquid extraction solid-phase prior LC–MS/MS analysis. Both...

[(E)-3-(2-chlorophenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1,2,3,6-tetrahydropyridine-4-yl)phenyl)-2-propylene-1-one], L41, was found to be a potent cyclin-dependent kinase 1 inhibitor. To study its pharmacokinetic characteristics, simple, specific, sensitive and reproducible HPLC method developed validated quantitatively determine L41 in rat plasma. amlodipine besylate (internal standard, IS) were extracted from plasma by simple liquid–liquid extraction process with ethyl acetate....

This article has been retracted by the publisher.

Static var compensator (SVC) devices have an increasingly extensive application in modern substations to achieve voltage stability. While, due frequent switching of the thyristors, large amount electromagnetic interferences (EMI) are generated, which can cause malfunction SVC or unaccepted response victim positioned nearby. An advanced acquisition system is established implement on-site measurement so as obtain EMI data. The bursts radiated and conducted data within a power cycle...

In order to improve the breaking performance of ultra-high voltage SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> circuit breaker, an optimal design scheme for increasing straight line length nozzle throat is proposed. Based on numerical simulation gas flow field in optimized structure interrupter, influence breaker studied, and interrupter verified by test. The results experiment show that can effectively, which great significance...

This paper mainly elaborated some new problems on the fault location for half-wavelength transmission lines, and studied its method. The results of research show that accuracy traditional double-terminal method is poor lines. While adding traveling wave detection units along line using three-point can effectively improve accuracy. In addition, simulation indicate with increase number points, gradually improved. But when distance between two adjacent points reduced to a certain extent, no...

To reduce the operation power of circuit breaker interrupter, here, is divided into two parts: arc reaction force and kinetic energy moving parts, then reactive work calculation method are put forward. Based on above method, operating original structure improved interrupter obtained, comparison results shows that can power.